4.2 Review

Caenorhabditis elegans as a powerful tool in natural product bioactivity research

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Water-soluble and alkali-soluble polysaccharides from bitter melon inhibited lipid accumulation in HepG2 cells and Caenorhabditis elegans

Ying Zhu et al.

Summary: The study found that bitter melon polysaccharides have hypolipidemic effects, particularly alkali-soluble bitter melon polysaccharides showed better performance in accelerating glucose consumption and decreasing triglyceride content. They exhibited significant lipid-lowering effects in cell and nematode experiments.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Infectious Diseases

Effects of Essential Oils from Cymbopogon spp. and Cinnamomum verum on Biofilm and Virulence Properties of Escherichia coli O157:H7

Raffaella Scotti et al.

Summary: This study explored the potential of various essential oils in inhibiting the growth and gene expression of enterohemorrhagic Escherichia coli O157:H7. It was found that Cymbopogon martini essential oil had the ability to suppress biofilm formation and gene expression, with a minimal inhibitory concentration of 0.0075%. Additionally, the essential oils were able to impact zinc homeostasis and reduce the infectivity of E. coli O157:H7.

ANTIBIOTICS-BASEL (2021)

Article Biochemistry & Molecular Biology

Flavonoids' Effects on Caenorhabditis elegans' Longevity, Fat Accumulation, Stress Resistance and Gene Modulation Involve mTOR, SKN-1 and DAF-16

Maria Alejandra Guerrero-Rubio et al.

Summary: Flavonoids, potential nutraceutical compounds found in dairy food, are considered health-promoting compounds with promising therapeutic effects on neurological, inflammatory diseases, diabetes, and cancer. In Caenorhabditis elegans, chrysin, 6-hydroxyflavone, and baicalein were found to significantly extend lifespan, with effects mediated by different signaling pathways. Microarray analysis showed that baicalein downregulates important age-related genes such as mTOR and PARP.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

EGCG-Mediated Potential Inhibition of Biofilm Development and Quorum Sensing in Pseudomonas aeruginosa

Suqi Hao et al.

Summary: EGCG, a bioactive ingredient in green tea, demonstrated significant inhibitory effects on the production of virulence factors in Pseudomonas aeruginosa, potentially serving as a candidate for quorum sensing inhibition to combat bacterial infections.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Natural photosensitizers from Tripterygium wilfordii and their antimicrobial photodynamic therapeutic effects in a Caenorhabditis elegans model

Seemi Tasnim Alam et al.

Summary: The extract and photosensitizer-enriched fraction of Tripterygium wilfordii showed effective antimicrobial photodynamic treatment (APDT) effects, particularly against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans. Additionally, the photosensitizers were able to induce intracellular ROS production and showed strong APDT activity against skin pathogens like Staphylococcus epidermidis and Streptococcus pyogenes. Overall, the use of TWE and TW-F5 in APDT was found to be successful in controlling pathogenic bacteria.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

Article Cell Biology

Antioxidant Activities of Commiphora leptophloeos (Mart.) J. B. Gillett) (Burseraceae) Leaf Extracts Using In Vitro and In Vivo Assays

Maria Lucia da Silva Cordeiro et al.

Summary: The study evaluated the chemical profile and antioxidant activity of Commiphora leptophloeos leaf extracts, finding that ethanol and methanol extracts displayed high antioxidant capacity and had no effect on non-tumour cells, but showed toxicity to tumour cells. In vivo assays using C. elegans N2 demonstrated that the ethanol extract was non-toxic, increased worm survival under oxidative stress, and reduced intracellular ROS levels. These findings suggest that the polyphenols in EE extract may have potential for various biotechnological applications.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Biochemistry & Molecular Biology

Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model

Hyemin Min et al.

Summary: The study found that supplementation with nicotinamide (NAM) can improve oocyte quality, reduce embryonic lethality, and promote germ cell apoptosis in female reproductive aging. NAM supplementation in aged mothers also decreases ROS accumulation and improves mitochondrial function in oocytes, resulting in improved developmental growth and motility of offspring. These results suggest that NAM supplementation in aging mothers enhances offspring health by modulating mitochondrial function and improving oocyte quality.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Quo Vadis Caenorhabditis elegans Metabolomics-A Review of Current Methods and Applications to Explore Metabolism in the Nematode

Liesa Salzer et al.

Summary: Metabolomics and lipidomics have gained interest in the model organism C. elegans due to its fast development, easy cultivation, and existing genetic tools. Different analytical approaches such as NMR, mass spectrometry, and chromatography have been employed for metabolomic analyses. The reviewed literature also includes application fields, bioinformatic tools, and a curated collection of metabolites and lipids for a future C. elegans-specific metabolome database.

METABOLITES (2021)

Article Cell Biology

Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans

Benjamin Dilberger et al.

Summary: The study found that protocatechuic acid, gallic acid, and vanillic acid can significantly increase the lifespan, heat-stress resistance, and chemotaxis of Caenorhabditis elegans, while activating longevity pathways. However, vanillic acid also decreases ATP concentrations in aged nematodes. The investigated phenolic acids were unable to affect mitochondrial performance, suggesting a hormetic mode of action, especially through activation of the sirtuin pathway.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Immunology

Sesamin and sesamolin rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through the attenuation of quorum sensing regulated virulence factors

V. T. Anju et al.

Summary: The study discussed the anti-quorum sensing and antibiofilm properties of lignans found in sesame seeds against Pseudomonas aeruginosa, providing insights into the development of novel anti-infectives against this pathogen. The lignans showed effects on virulence factor production, biofilm formation, and bacterial motility, with potential therapeutic opportunities for human use. The mechanism of action of lignans included down-regulation of QS regulated gene expression, affecting biofilm constituents, and exerting an anti-infective property in vitro and in vivo models.

MICROBIAL PATHOGENESIS (2021)

Article Biochemistry & Molecular Biology

Practical High-Throughput Method to Screen Compounds for Anthelmintic Activity against Caenorhabditis elegans

Aya C. Taki et al.

Summary: In this study, a high throughput screening assay relying on infrared light-interference to measure the motility of Caenorhabditis elegans was established. Small molecules from a library were screened, resulting in the identification of compounds that inhibit nematode motility. Future work will evaluate the potential of these hits for development as new anthelmintic candidates.

MOLECULES (2021)

Review Biotechnology & Applied Microbiology

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

E. Elizabeth Patton et al.

Summary: Zebrafish have become a valuable tool in drug discovery, particularly in screening, disease modeling, and toxicity assays. Recent advances in gene modification technologies and xenografts have enabled personalized treatments and rapid drug discovery platforms using zebrafish models. The unique features of zebrafish make them an important model organism for maximizing potential in medical discoveries.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

Small flexible automated system for monitoring Caenorhabditis elegans lifespan based on active vision and image processing techniques

Joan Carles Puchalt et al.

Summary: A new monitoring machine, SiViS, was developed for analyzing C. elegans cultures seeded with E. coli using standard Petri plates. The system utilizes active vision illumination and image-processing pipelines for motion detection, demonstrating consistent replicates in lifespan experiments and no significant differences compared to manual assays. The flexibility of SiViS allows adaptation to other C. elegans studies beyond longevity assays.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Ece Polat et al.

Summary: Antimicrobial photodynamic therapy (APDT) is constantly evolving as an effective method to combat antimicrobial resistance, utilizing reactive oxygen species produced by photosensitizers to destroy microorganisms. Research is ongoing to investigate various photosensitizers and explore new methods to enhance the properties of APDT.

BIOMEDICINES (2021)

Article Biochemistry & Molecular Biology

Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans

Hui Wang et al.

Summary: The study showed that total ginsenosides (TGS) can extend the lifespan of worms, improve mobility, have antioxidant and health benefits, and achieve these effects by activating signaling pathways related to antioxidant regulation and longevity.

FOOD & FUNCTION (2021)

Article Biochemistry & Molecular Biology

Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models

Hui Li et al.

Summary: The study demonstrates the protective effects of caffeic acid against Alzheimer's disease, including reducing toxicity, extending lifespan, and improving reproductive defects. Its mechanism of action involves activating specific signaling pathways.

FOOD & FUNCTION (2021)

Article Biotechnology & Applied Microbiology

Hibiscus sabdariffa Extract Inhibits Adhesion, Biofilm Initiation and Formation in Candida albicans

Meenakshi Dwivedi et al.

INDIAN JOURNAL OF MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Metabolites Produced by the Oral Commensal Bacterium Corynebacterium durum Extend the Lifespan of Caenorhabditis elegans via SIR-2.1 Overexpression

Jun Hyeong Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

Giovanni Brunetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Optics

A novel fluorogenic probe for visualizing the hydrogen peroxide in Parkinson's disease models

Gaobin Zhang et al.

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES (2020)

Article Biochemistry & Molecular Biology

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models

Gabriele Di Rosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemical Research Methods

Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans

Celine N. Martineau et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

Review Endocrinology & Metabolism

Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

Siwen Zhang et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Pharmacology & Pharmacy

Beneficial effects of sappanone A on lifespan and thermotolerance in Caenorhabditis elegans

Jingwei Zhao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

Rosina Pryor et al.

Article Engineering, Environmental

Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study

Paul Wittkowski et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2019)

Article Multidisciplinary Sciences

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

Leila Lesanpezeshki et al.

SCIENTIFIC REPORTS (2019)

Article Medicine, Research & Experimental

Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota

Nawaphat Malaiwong et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Effects of Momordica saponin extract on alleviating fat accumulation in Caenorhabditis elegans

Chunxiu Lin et al.

FOOD & FUNCTION (2019)

Review Immunology

Caenorhabditis elegans in high-throughput screens for anti-infective compounds

Nicholas D. Peterson et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

Article Microbiology

5-hydroxymethyl-2-furaldehyde from marine bacterium Bacillus subtilis inhibits biofilm and virulence of Candida albicans

Ganapathy Ashwinkumar Subramenium et al.

MICROBIOLOGICAL RESEARCH (2018)

Article Multidisciplinary Sciences

Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa

Jayalekshmi Haripriyan et al.

SCIENTIFIC REPORTS (2018)

Article Parasitology

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Frederick A. Partridge et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2018)

Article Biology

OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans

Gopal P. Sarma et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

Review Chemistry, Physical

Recent Advances in Fluorescent Probes for Lipid Droplets

Tkhe Kyong Fam et al.

MATERIALS (2018)

Article Mathematical & Computational Biology

A Cell Atlas for the Mouse Brain

Csaba Eroe et al.

FRONTIERS IN NEUROINFORMATICS (2018)

Article Plant Sciences

Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

Se-Myeong Cheon et al.

PHARMACEUTICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Survival assays using Caenorhabditis elegans

Hae-Eun H. Park et al.

MOLECULES AND CELLS (2017)

Article Multidisciplinary Sciences

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

Hoe-Yune Jung et al.

SCIENTIFIC REPORTS (2017)

Review Neurosciences

Diet-Induced Obesity and Circadian Disruption of Feeding Behavior

Aurea Blancas-Velazquez et al.

FRONTIERS IN NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Microbial Genetic Composition Tunes Host Longevity

Bing Han et al.

Article Biochemistry & Molecular Biology

Delaying aging in Caenorhabditis elegans with protein aggregation inhibitors

Karina Cuanalo-Contreras et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Cell Biology

Chemical activation of a food deprivation signal extends lifespan

Mark Lucanic et al.

AGING CELL (2016)

Review Biochemistry & Molecular Biology

In Vivo Detection of Reactive Oxygen Species and Redox Status in Caenorhabditis elegans

Bart P. Braeckman et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Nutrition & Dietetics

Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

Seul-Ki Park et al.

NUTRITION RESEARCH AND PRACTICE (2016)

Article Biochemistry & Molecular Biology

An oxidative fluctuation hypothesis of aging generated by imaging H2O2 levels in live Caenorhabditis elegans with altered lifespans

Xinmiao Fu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Genetics & Heredity

A Transparent Window into Biology: A Primer on Caenorhabditis elegans

Ann K. Corsi et al.

GENETICS (2015)

Article Genetics & Heredity

A Transparent Window into Biology: A Primer on Caenorhabditis elegans

Ann K. Corsi et al.

GENETICS (2015)

Review Biochemistry & Molecular Biology

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

Sergey I. Dikalov et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Biology

Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?

Julijana Gjorgjieva et al.

BIOSCIENCE (2014)

Article Biochemistry & Molecular Biology

Chemical Detoxification of Small Molecules by Caenorhabditis elegans

Gregory S. Stupp et al.

ACS CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16

Christian Buechter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Mathematical & Computational Biology

Biological modeling of complex chemotaxis behaviors for C. elegans under speed regulation-a dynamic neural networks approach

Jian-Xin Xu et al.

JOURNAL OF COMPUTATIONAL NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different Methods

Shan-Qing Zheng et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Photooxidation of Amplex red to resorufin: Implications of exposing the Amplex red assay to light

Baozhong Zhao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemical Research Methods

Potential New Method of Mixture Effects Testing Using Metabolomics and Caenorhabditis elegans

Oliver A. H. Jones et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Article Biochemistry & Molecular Biology

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

Daniela Knoefler et al.

MOLECULAR CELL (2012)

Article Parasitology

RNA interference in Caenorhabditis elegans: Uptake, mechanism, and regulation

Jimmy J. Zhuang et al.

PARASITOLOGY (2012)

Article Cell Biology

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

Matthew D. McGee et al.

AGING CELL (2011)

Article Biochemical Research Methods

OrthoDisease: tracking disease gene orthologs across 100 species

Kristoffer Forslund et al.

BRIEFINGS IN BIOINFORMATICS (2011)

Article Biochemistry & Molecular Biology

A Nuclear-Localized Fluorescent Hydrogen Peroxide Probe for Monitoring Sirtuin-Mediated Oxidative Stress Responses In Vivo

Bryan C. Dickinson et al.

CHEMISTRY & BIOLOGY (2011)

Article Chemistry, Medicinal

Youngia denticulata Protects Against Oxidative Damage Induced by tert-Butylhydroperoxide in HepG2 Cells

Kyungsu Kang et al.

JOURNAL OF MEDICINAL FOOD (2011)

Article Cell Biology

Lipid droplets as ubiquitous fat storage organelles in C. elegans

Shaobing O. Zhang et al.

BMC CELL BIOLOGY (2010)

Review Neurosciences

Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

Maria Dimitriadi et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Biochemistry & Molecular Biology

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

Terence I. Moy et al.

ACS CHEMICAL BIOLOGY (2009)

Article Cell Biology

Caenorhabditis elegans as an emerging model for studying the basic biology of obesity

Kevin T. Jones et al.

DISEASE MODELS & MECHANISMS (2009)

Article Multidisciplinary Sciences

The Influence of Bacterial Diet on Fat Storage in C. elegans

Kyleann K. Brooks et al.

PLOS ONE (2009)

Article Endocrinology & Metabolism

Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms

Shyr-Yeu Lin et al.

MOLECULAR ENDOCRINOLOGY (2008)

Review Biotechnology & Applied Microbiology

Finding function in novel targets:: C-elegans as a model organism

T Kaletta et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemical Research Methods

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

VV Belousov et al.

NATURE METHODS (2006)

Article Multidisciplinary Sciences

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

JG Wood et al.

NATURE (2004)

Article Biochemical Research Methods

Genorne-wide RNAi screening in Caenorhabditis elegans

RS Kamath et al.

METHODS (2003)

Article Multidisciplinary Sciences

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

K Ashrafi et al.

NATURE (2003)

Review Geriatrics & Gerontology

Advantages and disadvantages of Caenorhabditis elegans for aging research

TE Johnson

EXPERIMENTAL GERONTOLOGY (2003)

Article Multidisciplinary Sciences

Using RNA interference to identify genes required for RNA interference

NR Dudley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes

E Culetto et al.

HUMAN MOLECULAR GENETICS (2000)