期刊
JOURNAL OF BIOTECHNOLOGY
卷 234, 期 -, 页码 139-157出版社
ELSEVIER
DOI: 10.1016/j.jbiotec.2016.07.022
关键词
Flexible feedstock concept; Metabolic engineering; Strain development; Lignocellulosics; Biofuels; Bio-based value-added chemicals; Second generation feedstocks; E. coli; C. glutamicum; Bacillus; Pseudomonas; Yeast; Biorefinery; Hydrolysates; Methanol; CO2
资金
- ERASysAPP project MetApp
- ZIM, BMWi [KF2969004SB4]
Most biotechnological processes are based on glucose that is either present in molasses or generated from starch by enzymatic hydrolysis. At the very high, million-ton scale production volumes, for instance for fermentative production of the biofuel ethanol or of commodity chemicals such as organic acids and amino acids, competing uses of carbon sources e.g. in human and animal nutrition have to be taken into account. Thus, the biotechnological production hosts E. coli, C. glutamicum, pseudomonads, bacilli and Baker's yeast used in these large scale processes have been engineered for efficient utilization of alternative carbon sources. This flexible feedstock concept is central to the use of non-glucose second and third generation feedstocks in the emerging bioeconomy. The metabolic engineering efforts to broaden the substrate scope of E. coli, C. glutamicum, pseudomonads, B. subtilis and yeasts to include non-native carbon sources will be reviewed. Strategies to enable simultaneous consumption of mixtures of native and non-native carbon sources present in biomass hydrolysates will be summarized and a perspective on how to further increase feedstock flexibility for the realization of biorefinery processes will be given. (C) 2016 Elsevier B.V. All rights reserved.
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