期刊
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
卷 28, 期 8, 页码 1848-1858出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/10781552221096165
关键词
lymphoma; pharmacotherapy; antibody drug conjugate; CAR T-cell
This review discusses the pharmacology, efficacy, safety, dosing, and administration of new agents for the treatment of relapsed/refractory DLBCL.
Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive non-Hodgkin lymphoma. Approximately 40% of patients with DLBCL will experience disease relapse or will be refractory to first line chemoimmunotherapy, necessitating second-line salvage therapy. This has historically consisted of platinum-based chemotherapy regimens followed by autologous hematopoietic stem cell transplantation with curative intent for transplant-eligible patients or palliative chemotherapy for transplant-ineligible patients. In recent years there have been several new therapeutic agents approved for the treatment of relapsed/refractory DLBCL, thereby expanding the therapeutic landscape. These agents include polatuzumab vedotin, tafasitamab, loncastuximab tesirine, selinexor, and anti-CD19 chimeric antigen receptor T-cell therapies such as axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel. This review summarizes the pharmacology, efficacy, safety, dosing, and administration of new agents recently approved for the treatment of relapsed/refractory DLBCL.
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