Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation

Article Gastroenterology & Hepatology

Center Variability in Acute Rejection and Biliary Complications After Pediatric Liver Transplantation

Mounika Kanneganti et al.

Summary: This study found that there are variations in outcomes other than survival for pediatric liver transplant recipients among different transplant centers, specifically in terms of acute rejection rate and biliary complication rate. Center management differences were identified as a key driver of acute rejection rate performance, with less impact on biliary complication rate performance. Further research is needed to identify sources of variability in order to enhance outcomes for pediatric liver transplant recipients more broadly.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Approaches to Research Determination of Late Acute Cellular Rejection in Pediatric Liver Transplant Recipients

George V. Mazariegos et al.

Summary: The study evaluated interrater reliability of readings of rejection in liver transplant clinical trials using digitized slides, showing substantial disagreement initially among experienced pathologists but improved reliability with a unique study-specific procedure. This suggests the potential for such procedures to increase reliability in histopathologic determinations in future research and possibly in clinical settings.

LIVER TRANSPLANTATION (2021)

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Article Surgery

OPTN/SRTR 2019 Annual Data Report: Liver

A. Kwong et al.

Summary: The year 2019 saw significant changes in liver transplant policies, including adjustments to exception points and priority systems, the implementation of a National Liver Review Board, and a short-lived national acuity circle liver distribution policy. Additionally, there was a continued increase in living-donor liver transplants, with lower transplant rates but higher pretransplant mortality rates for women.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Urology & Nephrology