4.6 Article

Application of sulfur and nitrogen doped carbon quantum dots as sensitive fluorescent nanosensors for the determination of saxagliptin and gliclazide

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ROYAL SOCIETY OPEN SCIENCE
卷 9, 期 6, 页码 -

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ROYAL SOC
DOI: 10.1098/rsos.220285

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gliclazide; saxagliptin; sulfur and nitrogen-carbon quantum dots; fluorescent nanosensors; tablets

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In this study, highly fluorescent sulfur and nitrogen doped carbon quantum dots were used as nanosensors for the direct estimation of gliclazide and saxagliptin. The method does not require any pre-derivatization steps and the mechanism of interaction between the quantum dots and the drugs was studied.
In this study, highly fluorescent sulfur and nitrogen doped carbon quantum dots (S,N-CQDs) were used as fluorescent nanosensors for direct spectrofluorimetric estimation of each of gliclazide (GLZ) and saxagliptin (SXG) without any pre-derivatization steps for the first time. S,N-CQDs were synthesized employing a simple hydrothermal technique using citric acid and thiosemicarbazide. The produced S,N-CQDs were characterized using different techniques including fluorescence emission spectroscopy, UV spectrophotometry, high-resolution transmission electron microscopy and FT-IR spectroscopy. Following excitation at 360 nm, S,N-CQDs exhibited a strong emission peak at 430 nm. The native fluorescence of S,N-CQDs was quantitatively enhanced by addition of increased concentrations of the studied drugs. The fluorescence enhancement of S,N-CQDs and the concentrations of the studied drugs revealed a wide linear relationship in the range of 30.0-500.0 mu M and 75.0-600.0 mu M with limits of detection of 5.0 and 10.15 mu M for GLZ and SXG, respectively. The proposed method was efficiently used for determination of cited drugs in their commercial tablets with % recoveries ranging from 98.6% to 101.2% and low % relative standard deviation values (less than 2%). The mechanism of interaction between S,N-CQDs and the two drugs was studied. Validation of the proposed method was carried out in accordance with International Conference on Harmonization (ICH) guidelines.

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