期刊
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
卷 18, 期 -, 页码 3273-3282出版社
ELSEVIER
DOI: 10.1016/j.jmrt.2022.03.136
关键词
Centrifugal spinning; Drug release; Polylactic acid; Scaffold; Wound dressing
资金
- FAPESP [2020/07923-0]
- Sao Paulo Research Foundation
Polymeric membranes are a promising alternative to conventional dressings for wound-healing applications. This study successfully produced and characterized poly(L-lactic acid) membranes incorporated with curcumin particles using rotary jet spinning technique. The membranes demonstrated thermal stability, adequate mechanical strength, low degradation rates, and sustained release of curcumin.
Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 mm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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