期刊
CHEMNANOMAT
卷 8, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cnma.202200014
关键词
ferrite; magnetic nanoparticles; magnetic resonance imaging; relaxation; theranostics
资金
- Precursory Research for Embryonic Science and Technology at the Japan Science and Technology Agency
- JST-Mirai Program [JPMJMI17D7]
- [25286041]
Co1-xMgxFe2O4 nanoparticles embedded in amorphous SiO2 were prepared using a wet chemical method. These nanoparticles exhibited a significant T-2 shortening effect and effective relaxivity in magnetic resonance imaging, as well as specific binding to maleimide proteins.
Co1-xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin-echo magnetic resonance imaging measurements for Co1-xMgxFe2O4 nanoparticles using a 0.3-T MRI system. The particles exhibited a significant T-2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R-2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.
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