Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes

Pharmacomicrobiomics refers to the interactions between foreign compounds and the gut microbiome resulting in heterogeneous efficacy, side effects, and toxicity of the compound concerned. Glucose lowering drugs reduce blood glucose by modulating insulin secretion and its actions as well as redistributing energy disposal. Apart from genetic, ecological, and lifestyle factors, maintaining an equilibrium of the whole gut microbiome has been shown to improve human health. Microbial fingerprinting using faecal samples indicated an 'invisible phenotype' due to different compositions of microbiota which might orchestrate the interactions between patients' phenotypes and their responses to glucose-lowering drugs. In this article, we summarize the current evidence on differences in composition of gut microbiota between individuals with type 2 diabetes (T2D) and healthy individuals, the disruption of the balance of beneficial and pathogenic microbiota was shown in patients with T2D and how Western Medicine (WM) and Traditional Chinese Medicine (TCM) might re-shape the gut microbiota with benefits to the host immunity and metabolic health. We particularly highlighted the effects of both WM and TCM increase the relative abundance of health promoting bacteria, such as, Akkermansia muciniphila, Blautia, and Bifidobacterium adolescentis, and which have been implicated in type 2 diabetes (T2D). Several lines of evidence suggested that TCM might complement the efficacy of WM through alteration of microbiota which warrants further investigation in our pursuit of prevention and control of T2D.

Automated summary

Pharmacomicrobiomics investigates the interactions between foreign compounds and the gut microbiome, which play a significant role in the efficacy, side effects, and toxicity of the compounds. Glucose lowering drugs work by regulating insulin and energy disposal. In addition to genetic, ecological, and lifestyle factors, maintaining a balanced gut microbiome is crucial for human health. Different compositions of microbiota can influence patients' responses to glucose-lowering drugs. This article summarizes the differences in gut microbiota composition between individuals with type 2 diabetes and healthy individuals, and explores how Western Medicine and Traditional Chinese Medicine can shape the gut microbiota to improve immunity and metabolic health.