4.7 Article

Identification and Verification of Diagnostic Biomarkers for Glomerular Injury in Diabetic Nephropathy Based on Machine Learning Algorithms

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Plant Sciences

Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy via MAPK/NF-κB signaling pathways in C57BL/6 mice

Ying Li et al.

Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Medicine, General & Internal

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

Suetonia C. Palmer et al.

Summary: This network meta-analysis evaluated the effectiveness of SGLT-2 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes at varying cardiovascular and renal risk levels. The study found that both classes of drugs lowered mortality and improved cardiovascular outcomes, with notable differences in effects between the two agents. Additional benefits and adverse effects varied across different risk groups.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Endocrinology & Metabolism

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

Abigail C. Lay et al.

Summary: This study identified a crucial role of IGFBP-1 in the early development of type 2 diabetic kidney disease by regulating podocyte function, suggesting that maintaining glomerular IGFBP-1 levels could be beneficial in preserving podocyte function in the early stages of DKD.

DIABETOLOGIA (2021)

Article Genetics & Heredity

Identification of Hub Genes and Potential ceRNA Networks of Diabetic Nephropathy by Weighted Gene Co-Expression Network Analysis

Guoqing Li et al.

Summary: This study aimed to identify novel biomarkers and mechanisms for diabetic nephropathy (DN) disease progression through weighted gene co-expression network analysis. Four potential RNA regulatory pathways were proposed, and IL6, CXCL8, MMP9, and ATF3 were identified as markers for early diagnosis of DN. Insights into the disease development mechanisms in DN at the transcriptome level were provided.

FRONTIERS IN GENETICS (2021)

Article Cell Biology

CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

Yanjuan Hou et al.

Summary: In diabetic nephropathy, CD36 mediates ROS production that enhances NLRP3 inflammasome activation, leading to IL-1 beta secretion and cell apoptosis. Inhibition of CD36 protects mice from tubulointerstitial inflammation and tubular epithelial cell apoptosis.

CELL DEATH & DISEASE (2021)

Article Immunology

Identification of Inflammation-Related Biomarker Lp-PLA2 for Patients With COPD by Comprehensive Analysis

Mingming Deng et al.

Summary: This study aimed to identify effective biomarkers for COPD through differential expressed genes analysis and weighted co-expression network analysis. The results suggest that Lp-PLA2 may be a potential biomarker for assessing exercise tolerance in COPD patients.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biotechnology & Applied Microbiology

Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis

Yuejun Wang et al.

Summary: This study investigated immune-related biomarkers in diabetic nephropathy (DN) and identified FN1 and C3 as potential biomarkers. The study also explored the underlying mechanisms using bioinformatic approaches, and found that FN1 and C3 were negatively correlated with glomerular filtration rate in DN patients. Additionally, the study discovered potential therapeutic small molecule compounds in DN.

BIOENGINEERED (2021)

Article Cardiac & Cardiovascular Systems

Predicting Diagnostic Gene Biomarkers Associated With Immune Infiltration in Patients With Acute Myocardial Infarction

Enfa Zhao et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Review Urology & Nephrology

Glomerular mesangial cell and podocyte injuries in diabetic nephropathy

Chun-Wu Tung et al.

NEPHROLOGY (2018)

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Endocrinology & Metabolism

TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition

C. E. Hills et al.

DIABETOLOGIA (2012)

Review Biochemistry & Molecular Biology

Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer

Miranda P. Ween et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Biochemical Research Methods

A support vector machine-recursive feature elimination feature selection method based on artificial contrast variables and mutual information

Xiaohui Lin et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2012)

Review Biotechnology & Applied Microbiology

Sequencing technologies and genome sequencing

Chandra Shekhar Pareek et al.

JOURNAL OF APPLIED GENETICS (2011)

Article Biochemical Research Methods

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Matthew D. Wilkerson et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Urology & Nephrology

Macrophage accumulation in human progressive diabetic nephropathy

Duy Nguyen et al.

NEPHROLOGY (2006)

Article Endocrinology & Metabolism

Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

SW Ha et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2004)