期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.859638
关键词
type 1 diabetes mellitus; stem cell; beta-cell; immunotolerance; transplantation
资金
- National Natural Science Foundation of China [81971891, 82172196, 81772134]
- Key Laboratory of Emergency and Trauma (Hainan Medical University) of the Ministry of Education [KLET-202108]
- Hunan Province Natural Science Foundation of China [2018JJ3804]
- College Students' Innovation and Entrepreneurship Project [S20210026020013]
This review article discusses the application of stem cell transplantation in the treatment of type 1 diabetes mellitus (T1DM). Stem cells have the potential to reestablish immunotolerance and preserve islet beta-cell function, providing a promising alternative for T1DM treatment.
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic beta-cells, leading to the destruction of insulitis-related islet beta-cells. Islet beta-cell transplantation has been proven as a curative measure in T1DM. However, a logarithmic increase in the global population with diabetes, limited donor supply, and the need for lifelong immunosuppression restrict the widespread use of beta-cell transplantation. Numerous therapeutic approaches have been taken to search for substitutes of beta-cells, among which stem cell transplantation is one of the most promising alternatives. Stem cells have demonstrated the potential efficacy to treat T1DM by reconstitution of immunotolerance and preservation of islet beta-cell function in recent research. cGMP-grade stem cell products have been used in human clinical trials, showing that stem cell transplantation has beneficial effects on T1DM, with no obvious adverse reactions. To better achieve remission of T1DM by stem cell transplantation, in this work, we explain the progression of stem cell transplantation such as mesenchymal stem cells (MSCs), human embryonic stem cells (hESCs), and bone marrow hematopoietic stem cells (BM-HSCs) to restore the immunotolerance and preserve the islet beta-cell function of T1DM in recent years. This review article provides evidence of the clinical applications of stem cell therapy in the treatment of T1DM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据