4.7 Review

Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

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Concordant Androgen-Regulated Expression of Divergent Rhox5 Promoters in Sertoli Cells

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Summary: This article reports a case of concordant transcriptional regulation that drives a single protein to be produced from divergent promoters in the same cell type. The gene product, RHOX5 homeobox transcription factor, is translated from two different mRNAs transcribed from alternative promoters. The study found that despite the differences in tissue-specific activity and sequence identity between the two promoters, they exhibit a similar expression pattern in the testes, depending on androgen signaling for expression in Sertoli cells during spermatogenesis.

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Seminal exosomal miR-210-3p as a potential marker of Sertoli cell damage in varicocoele

Yi Ma et al.

Summary: The study found that seminal exosomal miR-210-3p levels were positively correlated with the severity of varicocoele in patients, while negatively correlated with sperm count and seminal inhibin-B expression. Surgical treatment significantly reduced the level of miR-210-3p.

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Summary: This study identified region-specific AKT phosphorylation in Sertoli cells of the Sertoli valve (SV) and demonstrated non-cell autonomous specialization in this region. Fibroblast growth factors (FGFs) derived from the rete testis (RT) and low levels of retinoic acid (RA) signaling contribute to the regionalization of SV epithelia and the local maintenance of undifferentiated spermatogonia in the SV region.

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Sertoli cell-derived exosomal MicroRNA-486-5p regulates differentiation of spermatogonial stem cell through PTEN in mice

Quan Li et al.

Summary: The study reveals the role of miR-486-5p in mediating communication between Sertoli cells and SSCs through exosomes, promoting the differentiation of SSCs. This provides new insights into the molecular mechanisms regulating SSC differentiation.

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An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

Shinnosuke Suzuki et al.

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Insights into differentiation and function of the transition region between the seminiferous tubule and rete testis

A. F. A. Figueiredo et al.

Summary: The transition region, connecting the seminiferous tubules to the rete testis, is a specialized area with unique morphological, molecular, and physiological features. It is believed to serve as a niche for undifferentiated Sertoli cells and spermatogonial stem cells. Additionally, the region is populated by a high number of immune cells, suggesting a role in monitoring and responding to potential leakage of autoantigens as sperm enter the rete testis.

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Differential RA responsiveness among subsets of mouse late progenitor spermatogonia

Shinnosuke Suzuki et al.

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The rete testis harbors Sertoli-like cells capable of expressing DMRT1

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Retinoic Acid and Germ Cell Development in the Ovary and Testis

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Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis

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Testosterone and FSH modulate Sertoli cell extracellular secretion: Proteomic analysis

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Regionally distinct patterns of STAT3 phosphorylation in the seminiferous epithelia of mouse testes

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A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq

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Only a small population of adult Sertoli cells actively proliferates in culture

Andrey Yu Kulibin et al.

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CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis

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Processive Pulses of Retinoic Acid Propel Asynchronous and Continuous Murine Sperm Production

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Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis

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Computer simulations of the mouse spermatogenic cycle

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Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice

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Germline niche transplantation restores fertility in infertile mice

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A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

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Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells

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