Severe Intravascular Hemolysis from Clostridium perfringens Septicemia in a Neonate with Necrotizing Enterocolitis in China: A Case Report

Review Hematology

Clostridium perfringens sepsis in three patients with acute leukemia and review of the literature

Fuhong Liu et al.

Summary: Clostridium perfringens sepsis in patients with acute leukemia is rare but progresses rapidly with a high mortality rate. Early detection and diagnosis are crucial, and multimodal treatment strategies are essential for success.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Article Medicine, General & Internal

Next-generation sequencing diagnostics of bacteremia in pediatric sepsis

Thomas Schmoch et al.

Summary: Sepsis and septic shock have a significant impact on infants and young children, underscoring the need for fast and more sensitive diagnostic methods. The Next GeneSiPS-Trial aims to evaluate the diagnostic performance of NGS technology in critically ill pediatric patients with severe infections.

MEDICINE (2021)

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Article Microbiology

Pathogenic Characterization of Clostridium perfringens Strains Isolated From Patients With Massive Intravascular Hemolysis

Ai Suzaki et al.

Summary: This study investigated the pathogenic mechanism of massive intravascular hemolysis (MIH) in sepsis caused by Clostridium perfringens. The findings suggest that perfringolysin O (PFO) may be a major virulence factor of sepsis with MIH, inducing potent cytotoxic and proinflammatory cytokine effects which could influence the rapid progression of this fatal disease.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Pediatrics