期刊
INFECTION AND DRUG RESISTANCE
卷 15, 期 -, 页码 641-654出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S342103
关键词
Klebsiella pneumoniae; bloodstream infection; carbapenem resistance; hospital-acquired infection; risk factors
资金
- National Natural Science Foundation of China [81973983]
- Collaborative Tackling and Public Health Collaborative Innovation Project in Anhui Province [GXXT-2020-018]
- joint construction project of clinical medicine university and hospital [2021lcxk006]
- Natural Science Research Project of Universities in Anhui Province [KJ2020A0176]
- Borrowing and Transferring Subsidy Project in 2019, Hefei [J2019Y04]
The proportion of hospital-acquired infections among KP BSI patients has increased over the years, as well as the detection rate of CRKP among KP BSI patients. Exposure to BLBLIs, carbapenems, and solid organ transplantation were identified as independent risk factors for hospital-acquired CRKP BSI. CRKP BSI, septic shock, prolonged mechanical ventilation, and low platelet counts are associated with a higher 28-day mortality rate among hospital-acquired KP BSI patients.
Purpose: This study aimed to describe trends in Klebsiella pneumoniae (KP) resistance in bloodstream infections (BSI) and to identify risk factors for a hospital-acquired carbapenemresistant Klebsiella pneumoniae (CRKP) BSI and 28-day mortality from a hospital-acquired Patients and Methods: We recorded the results of antimicrobial susceptibility testing of 396 KP-positive blood cultures from January 2016 to December 2020. A total of 277 patients with a KP BSI were included in this study, of which 171 had a hospital-acquired infection and 84 had a hospital-acquired CRKP BSI. Multivariate logistic regression analysis was used to identify risk factors for a hospital-acquired CRKP BSI and 28-day mortality from Results: The proportion of hospital-acquired infections among KP BSI patients increased from 53.1% in 2016 to 72.8% in 2020. The detection rate of CRKP among KP BSI patients increased from 18.8% in 2016 to 37.7% in 2020. Multivariate logistic regression showed that 13-lactam/13-lactamase inhibitor combinations (BLBLIs) exposure (P = 0.022, OR 2.863), carbapenems exposure (P = 0.007, OR 3.831) and solid organ transplantation (P 0.001, OR 19.454) were independent risk factors for a hospital-acquired CRKP BSI. Risk factors for a 28-day mortality from hospital-acquired KP BSI were CRKP BSI (P =0.009, OR 5.562), septic shock (P =0.002, OR 4.862), mechanical ventilation 96 hours (P =0.020, OR 8.765), and platelet counts <100x109/L (P =0.003, OR 4.464). Conclusion: The incidence of hospital-acquired KP BSI continues to rise and the proportion of CRKP BSI is also increasing. We believe that the use of the BLBLIs needs to be carefully evaluated in hospital-acquired infection. Hospital-acquired KP BSI Patients with CRKP BSI, septic shock, mechanical ventilation and deficiency of platelets are more likely to have a poor prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据