期刊
INFECTION AND DRUG RESISTANCE
卷 15, 期 -, 页码 1067-1076出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S349607
关键词
Mycobacterium tuberculosis; tuberculosis; droplet digital PCR; diagnosis; drug resistance test; disease transmission
资金
- National Natural Science Foundation of China [82160304, 81560596, 81860644]
- Joint Foundation of Yunnan Province Department of Science, Technology-Kunming Medical University [2019FE001 (-002), 2017FE467 (-001)]
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, and the emergence of drug-resistant strains has made early diagnosis and drug sensitivity testing more challenging. Droplet digital PCR is a promising diagnostic technology with high sensitivity and no need for calibration, and it has the potential to improve diagnosis and monitoring of tuberculosis.
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) infection, which has seriously endangered human health for many years. With the emergence of multidrug-resistant and extensively drug-resistant MTB, the prevention and treatment of TB has become a pressing need. Early diagnosis, drug resistance monitoring, and control of disease transmission are critical aspects in the prevention and treatment of TB. However, the currently available diagnostic technologies and drug sensitivity tests are time consuming, and thus, it is difficult to achieve the goal of early diagnosis and detection drug sensitivity, which results in limited control of disease transmission. The development of molecular testing technology has gradually achieved the vision of rapid and accurate diagnosis of TB. Droplet digital PCR (ddPCR) is an excellent nucleic acid quantification method with high sensitivity and no need for a calibration curve. Herein, we review the application of ddPCR in TB diagnosis and drug resistance detection and transmission monitoring.
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