期刊
JOURNAL OF BIOTECHNOLOGY
卷 234, 期 -, 页码 66-70出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2016.07.020
关键词
L. plantarum LZ227; Complete genome sequence; B-group vitamins; Folate; Riboflavin
资金
- International Science & Technology Cooperation Program of China [2013DFA32330]
- National Science Foundation of China [31540044, 31271821]
- National High Technology Research and Development Program (863 Program) of China [2014AA022210-08]
- National Science Foundation of Zhejiang Province [LY16C200002]
- Science Foundation of the Zhejiang Education Department [Y201534497]
- National Research Foundation for the Doctoral Program of Higher Education [20133326110005]
B-group vitamins play an important role in human metabolism, whose deficiencies are associated with a variety of disorders and diseases. Certain microorganisms such as Lactic acid bacteria (LAB) have been shown to have capacities for B-group vitamin production and thus could potentially replace chemically synthesized vitamins for food fortification. A potential probiotic strain named Lactobacillus plantarum LZ227, which was isolated from raw cow milk in this study, exhibits the ability to produce B-group vitamins. Complete genome sequencing of LZ227 was performed to gain insights into the genetic elements involved in B-group vitamin production. The genome of LZ227 contains a circular 3,131,750-bp chromosome, three circular plasmids and two predicted linear plasmids. LZ227 also contains gene clusters for biosynthesis of both riboflavin and folate. This genome sequence provides a basis for further elucidation of its molecular genetics and probiotic functions, and will facilitate its applications as starter cultures in food industry. (C) 2016 Elsevier B.V. All rights reserved.
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