期刊
JOURNAL OF BIOSCIENCES
卷 41, 期 3, 页码 507-534出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-016-9616-y
关键词
Cancer; carbohydrate recognition domain; galectin-9; immune-regulation; linker peptide
类别
资金
- Department of Biotechnology, India [BT/RLF/Re-entry/16/2011]
Galectins is a family of non-classically secreted, beta-galactoside-binding proteins that has recently received considerable attention in the spatio-temporal regulation of surface 'signal lattice' organization, membrane dynamics, cell-adhesion and disease therapeutics. Galectin-9 is a unique member of this family, with two non-homologous carbohydrate recognition domains joined by a linker peptide sequence of variable lengths, generating isoforms with distinct properties and functions in both physiological and pathological settings, such as during development, immune reaction, neoplastic transformations and metastasis. In this review, we summarize the latest knowledge on the structure, receptors, cellular targets, trafficking pathways and functional properties of galectin-9 and discuss how galectin-9-mediated signalling cascades can be exploited in cancers and immunotherapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据