Enantioselective Allylic C-H Bond Oxidation of Olefins Using Copper Complexes of Chiral Oxazoline Based Ligands

This review article discusses historical and contemporary research studies of asymmetric allylic oxidation of olefins using homogeneous and heterogeneous copper complexes of various kinds of oxazoline-based ligands, until the end of 2021. It is revealed that this strategy is a powerful method to form a new stereogenic center bearing an oxygen substituent adjacent to an unchanged C=C bond. Enantioselectivities as well as chemical yields, and also the reactivity, are strongly dependent on the type of substrate, oxidant, the copper salt and its oxidation state, ligand structure, temperature, nature of the solvent, and additives such as phenylhydrazine and porous materials.

Automated summary

Asymmetric allylic oxidation is a powerful method to form a new stereogenic center, with enantioselectivities and chemical yields strongly dependent on various factors.