期刊
ACS CENTRAL SCIENCE
卷 8, 期 5, 页码 581-589出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.2c00004
关键词
-
资金
- National Natural Science Foundation of China [21821002]
This study successfully developed a method for C-H functionalization of free phenols using Rh(II) and Xantphos ligand as catalyst, which exhibits para-selectivity and synthetic usefulness.
Para-selective C-H functionalization of free phenols by metal carbenoids is rather challenging due to the generally more favorable competing O-H insertion. Herein, with the use of the combination of Rh(II) and a Xantphos ligand as the catalyst, a novel multicomponent reaction of free phenols, diazoesters, and allylic carbonates was successfully developed, affording a wide variety of phenol derivatives, bearing an all-carbon quaternary center and a synthetically useful allylic unit. This reaction is likely to occur through a tandem process of carbene-induced para-selective C-H functionalization, followed by Rh(II)/Xantphos-catalyzed allylation. The distinctive reactivity of para-selective C-H rather than O-H insertion for the carbenoid intermediate, combined with features of excellent functional group compatibility, high atom and step economy, and ease in further diversification of the products, might render this protocol highly attractive in facile functionalization of unprotected phenols.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据