期刊
PROBIOTICS AND ANTIMICROBIAL PROTEINS
卷 14, 期 4, 页码 727-740出版社
SPRINGER
DOI: 10.1007/s12602-022-09942-4
关键词
Probiotic; Yeast; Anti-MRSA; Starmerella bacillaris; In vitro
资金
- National Natural Science Foundation of China [31772082]
- 13th Five-Year Plan Science and Technology Project of the Education Department of Jilin Province [JJKH20201017KJ]
This study isolated 15 strains of anti-MRSA probiotic yeast from food and evaluated their characteristics and safety. Among them, Starmerella bacillaris CC-PT4 from grape peel showed good anti-MRSA ability and tolerance to various conditions, making it a potential candidate for probiotic yeast.
Methicillin-resistant Staphylococcus aureus (MRSA) is a disreputable pathogenic bacterium that has been proven to colonize the intestinal tract. The goal of this study is to find anti-MRSA probiotic yeast from food and evaluate its probiotic characteristics and safety. Finally, 15 strains were isolated from fruit peel with anti-MRSA ability. Using DNA sequence analysis, they were identified as the genus Hanseniaspora (7 strains) and Starmerella (8 strains). Starmerella bacillaris CC-PT4 (CGMCC No. 23573) that was isolated from the grape peel has good auto-aggregation ability and hydrophobicity, and can tolerate 0.3% bile, pH 2, simulated gastric fluid (SGF), and simulated intestinal fluid (SIF). Strikingly, Starmerella bacillaris CC-PT4, like commercial probiotic Saccharomyces boulardii CNCM 1-745 (Florastor (R)), can adapt to the temperature of the human body (37 degrees C). After safety assessment, this strain is sensitive to amphotericin B and cannot produced f3-hemolytic activities. Overall, this study provides a new candidate for probiotic yeast with anti-MRSA ability.
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