期刊
JOURNAL OF INFECTION AND PUBLIC HEALTH
卷 15, 期 3, 页码 293-296出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.jiph.2022.01.012
关键词
Neisseria meningitidis; Fluoroquinolones; Quinolones; Cephalosporins; Antimicrobial resistance; Stewardship; Antibiotic consumption; Bystander selection
This study found a positive correlation between the prevalence of meningococcal reduced susceptibility to cefotaxime and ciprofloxacin and the consumption of cephalosporins and quinolones. This finding emphasizes the importance of strengthening antimicrobial stewardship programs.
Background: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones. Methods: We used mixed-effects linear regression to assess if country-level prevalence of reduced sus-ceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of ce-phalosporins and quinolones in 13 European countries. Results: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001). Conclusions: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening anti-microbial stewardship programs. (C) 2022 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.
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