4.6 Review

Tuberculous Granuloma: Emerging Insights From Proteomics and Metabolomics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Microbiology

Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches

Charles M. Manyelo et al.

Summary: Tuberculous meningitis is a devastating form of tuberculosis with limited understanding of its immunology and pathogenesis. Further research is urgently needed to improve disease management and develop new therapeutic approaches.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Review Medicine, General & Internal

The Role of Complement System and the Immune Response to Tuberculosis Infection

Heena Jagatia et al.

Summary: The complement system plays a crucial role in orchestrating immune responses against Mycobacterium tuberculosis, activating different pathways to clear the pathogen. However, the bacteria can persist and evade clearance within macrophages, leading to the formation of granulomas which aim to contain the infection while sacrificing host tissue. The full extent of complement system involvement during M. tuberculosis infection is still not fully understood, but research is ongoing to uncover its contribution.

MEDICINA-LITHUANIA (2021)

Article Biochemistry & Molecular Biology

Urinary metabolomic analysis to identify potential markers for the diagnosis of tuberculosis and latent tuberculosis

Jiaheng Deng et al.

Summary: This study identified and analyzed the urinary metabolome of TB patients, finding that the metabolism of TB patients was disordered and many metabolic pathways changed, with GSH and histamine selected as potential molecular markers. The results provided potential for non-invasive biomarkers of TB.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Article Biochemical Research Methods

Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response

Analia Lima et al.

Summary: Mycobacterium tuberculosis's Ser/Thrprotein kinase PknG plays a key role in bacterial metabolism and survival within the host, yet the mechanisms underlying its regulatory functions remain largely unknown. The study revealed that the absence of PknG led to a remodeling of the mycobacterial proteome, affecting processes like cell envelope components biosynthesis and response to hypoxia, shedding light on new molecular mechanisms underlying PknG's role.

JOURNAL OF PROTEOMICS (2021)

Review Biochemistry & Molecular Biology

Metabolomics in infectious diseases and drug discovery

Vivian Tounta et al.

Summary: Metabolomics is a valuable tool used in conjunction with genomics, transcriptomics, and proteomics to understand host-pathogen interactions at the small-molecule level. Its main applications include prognostic and diagnostic purposes, as well as the discovery of druggable metabolic enzymes and regulators, and elucidation of metabolic mechanisms.

MOLECULAR OMICS (2021)

Review Biochemistry & Molecular Biology

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

Andre Campanico et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Immunology

The application of metabolomics toward pulmonary tuberculosis research

Ilse du Preez et al.

TUBERCULOSIS (2019)

Review Biochemical Research Methods

Recent insights into Mycobacterium tuberculosis through proteomics and implications for the clinic

Deepa Bisht et al.

EXPERT REVIEW OF PROTEOMICS (2019)

Article Multidisciplinary Sciences

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

Daniel J. Greenwood et al.

SCIENCE (2019)

Article Microbiology

Immunology of Mycobacterium tuberculosis Infections

Jonathan Kevin Sia et al.

MICROBIOLOGY SPECTRUM (2019)

Review Immunology

Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease

Jayne Louise Wilson et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Respiratory System

Diagnostic Tests for Latent Tuberculosis Infection

Michelle K. Haas et al.

CLINICS IN CHEST MEDICINE (2019)

Review Cell Biology

The pathogenesis of tuberculous meningitis

Angharad Grace Davis et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Review Immunology

Tuberculous meningitis in children: Clinical management & outcome

Bella Devaleenal Daniel et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Immunometabolism of Phagocytes During Mycobacterium tuberculosis Infection

Ranjeet Kumar et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2019)

Article Cell Biology

PknG supports mycobacterial adaptation in acidic environment

Ruchi Paroha et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)

Article Multidisciplinary Sciences

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis

Uma S. Gautam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Pathology

Microbial Offense vs Host Defense: Who Controls the TB Granuloma?

Amanda J. Martinot

VETERINARY PATHOLOGY (2018)

Editorial Material Immunology

Tuberculous meningitis: a roadmap for advancing basic and translational research

Sanjay K. Jain et al.

NATURE IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions

Mehak Zahoor Khan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Endocrinology & Metabolism

Urinary metabolite markers characterizing tuberculosis treatment failure

Laneke Luies et al.

METABOLOMICS (2017)

Review Clinical Neurology

Tuberculous meningitis

Robert J. Wilkinson et al.

NATURE REVIEWS NEUROLOGY (2017)

Review Biotechnology & Applied Microbiology

Multi-omics approaches to disease

Yehudit Hasin et al.

GENOME BIOLOGY (2017)

Article Microbiology

Pulmonary Tuberculosis

Sarah M. Lyon et al.

MICROBIOLOGY SPECTRUM (2017)

Article Orthopedics

Mycobacterium Tuberculosis in Spinal Tuberculosis

Myung-Sang Moon et al.

ASIAN SPINE JOURNAL (2017)

Article Chemistry, Multidisciplinary

On the outside looking in: redefining the role of analytical chemistry in the biosciences

Dominic J. Hare et al.

CHEMICAL COMMUNICATIONS (2016)

Article Medicine, Research & Experimental

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Thomas R. Lerner et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Inflammatory signaling in human tuberculosis granulomas is spatially organized

Mohlopheni J. Marakalala et al.

NATURE MEDICINE (2016)

Article Medicine, General & Internal

The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

Rein M. G. J. Houben et al.

PLOS MEDICINE (2016)

Review Immunology

Granulomas and inflammation: Host-Directed Therapies for Tuberculosis

Hlumani Ndlovu et al.

FRONTIERS IN IMMUNOLOGY (2016)

Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biotechnology & Applied Microbiology

Proteome signatures-how are they obtained and what do they teach us?

Joao Pinto da Costa et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)

Article Biochemical Research Methods

A Novel Tuberculosis Antigen Identified from Human Tuberculosis Granulomas

Yang Yu et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

Review Biochemical Research Methods

Proteomic contributions to our understanding of vaccine and immune responses

Allison C. Galassie et al.

PROTEOMICS CLINICAL APPLICATIONS (2015)

Article Medicine, Research & Experimental

Mycobacterium tuberculosis Metabolism

Digby F. Warner

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Respiratory System

Metabolomics: Applications and Promise in Mycobacterial Disease

Mehdi Mirsaeidi et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2015)

Article Cell Biology

Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum

Lisanne M. van Leeuwen et al.

DISEASE MODELS & MECHANISMS (2014)

Article Microbiology

Mycobacterium tuberculosis in the Proteomics Era

Martin Gengenbacher et al.

MICROBIOLOGY SPECTRUM (2014)

Review Immunology

The Immune Response in Tuberculosis

Anne O'Garra et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Medical Laboratory Technology

Decreased serum 5-oxoproline in TB patients is associated with pathological damage of the lung

Nanying Che et al.

CLINICA CHIMICA ACTA (2013)

Article Biochemical Research Methods

Application of 1H NMR Spectroscopy-Based Metabolomics to Sera of Tuberculosis Patients

Aiping Zhou et al.

JOURNAL OF PROTEOME RESEARCH (2013)

Article Medicine, Research & Experimental

A novel approach to eradicate latent TB: Based on resuscitation promoting factors

Khaled Seidi et al.

JOURNAL OF MEDICAL HYPOTHESES AND IDEAS (2013)

Review Immunology

The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?

Mayra Silva Miranda et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

Article Biochemical Research Methods

Metabolomic Signatures in Guinea Pigs Infected with Epidemic-Associated W-Beijing Strains of Mycobacterium tuberculosis

Bagganahalli S. Somashekar et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Article Medicine, Research & Experimental

Sarcoidosis: Can a murine model help define a role for silica?

Henry Yeager et al.

MEDICAL HYPOTHESES (2012)

Review Immunology

Revisiting the role of the granuloma in tuberculosis

Lalita Ramakrishnan

NATURE REVIEWS IMMUNOLOGY (2012)

Article Immunology

Latent tuberculosis: what the host sees?

Hannah P. Gideon et al.

IMMUNOLOGIC RESEARCH (2011)

Article Immunology

Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

Bisweswar Nandi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Biochemical Research Methods

1H NMR-based Metabolomic Profiling in Mice Infected with Mycobacterium tuberculosis

Ji-Hyun Shin et al.

JOURNAL OF PROTEOME RESEARCH (2011)

Article Biochemical Research Methods

Proteogenomic Analysis of Mycobacterium tuberculosis By High Resolution Mass Spectrometry

Dhanashree S. Kelkar et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Review Immunology

Macrophages and control of granulomatous inflammation in tuberculosis

J. L. Flynn et al.

MUCOSAL IMMUNOLOGY (2011)

Review Biochemistry & Molecular Biology

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

Kyu Y. Rhee et al.

TRENDS IN MICROBIOLOGY (2011)

Article Nutrition & Dietetics

Vitamin D status and antimicrobial peptide cathelicidin (LL-37) concentrations in patients with active pulmonary tuberculosis

Alexandra V. Yamshchikov et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

Article Medicine, Research & Experimental

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

Mi-Jeong Kim et al.

EMBO MOLECULAR MEDICINE (2010)

Article Genetics & Heredity

A genome-wide perspective of genetic variation in human metabolism

Thomas Illig et al.

NATURE GENETICS (2010)

Article Genetics & Heredity

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

Inaki Comas et al.

NATURE GENETICS (2010)

Article Multidisciplinary Sciences

Portrait of a Pathogen: The Mycobacterium tuberculosis Proteome In Vivo

Nicole A. Kruh et al.

PLOS ONE (2010)

Review Respiratory System

The immunology of tuberculosis: From bench to bedside

Keertan Dheda et al.

RESPIROLOGY (2010)

Review Biochemical Research Methods

Metabolomics: an integral technique in systems biology

Wolfram Weckwerth

BIOANALYSIS (2010)

Article Biochemistry & Molecular Biology

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

J. Muse Davis et al.

Review Medicine, Research & Experimental

Pathogenesis of Central Nervous System Tuberculosis

Nicholas A. Be et al.

CURRENT MOLECULAR MEDICINE (2009)

Review Immunology

Foamy macrophages and the progression of the human tuberculosis granuloma

David G. Russell et al.

NATURE IMMUNOLOGY (2009)

Review Microbiology

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Clifton E. Barry et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Review Biochemistry & Molecular Biology

Eliminating latent tuberculosis

Douglas B. Young et al.

TRENDS IN MICROBIOLOGY (2009)

Review Radiology, Nuclear Medicine & Medical Imaging

Pulmonary tuberculosis: Up-to-date imaging and management

Yeon Joo Jeong et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2008)

Review Microbiology

Central nervous system tuberculosis: Pathogenesis and clinical aspects

R. Bryan Rock et al.

CLINICAL MICROBIOLOGY REVIEWS (2008)

Article Immunology

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates

Laura E. Via et al.

INFECTION AND IMMUNITY (2008)

Article Immunology

Innate immunity in tuberculosis: myths and truth

Daniel S. Korbel et al.

MICROBES AND INFECTION (2008)

Article Medicine, Research & Experimental

Neutrophil-mediated innate immune resistance to mycobacteria

Adrian R. Martineau et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Infectious Diseases

T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward

Madhukar Pai et al.

LANCET INFECTIOUS DISEASES (2007)

Article Public, Environmental & Occupational Health

Modeling a syphilis outbreak through space and time using the Bayesian maximum entropy approach

Dionne C. Gesink Law et al.

ANNALS OF EPIDEMIOLOGY (2006)

Review Microbiology

The continuing challenges of leprosy

DM Scollard et al.

CLINICAL MICROBIOLOGY REVIEWS (2006)

Article Immunology

Lessons from experimental Mycobacterium tuberculosis infections

JoAnne L. Flynn

MICROBES AND INFECTION (2006)

Review Oncology

New insights into the function of granulomas in human tuberculosis

T Ulrichs et al.

JOURNAL OF PATHOLOGY (2006)

Article Infectious Diseases

Tuberculous meningitis and miliary tuberculosis: the Rich focus revisited

PR Donald et al.

JOURNAL OF INFECTION (2005)

Review Microbiology

Tuberculosis - Metabolism and respiration in the absence of growth

HIM Boshoff et al.

NATURE REVIEWS MICROBIOLOGY (2005)

Article Immunology

Vascular endothelial growth factor and blood-brain barrier disruption in tuberculous meningitis

M van der Flier et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2004)

Article Multidisciplinary Sciences

Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

A Walburger et al.

SCIENCE (2004)

Review Biochemical Research Methods

Has the yo-yo stopped? - An assessment of human protein-coding gene number

C Southan

PROTEOMICS (2004)

Review Immunology

Neutrophil granules and secretory vesicles in inflammation

M Faurschou et al.

MICROBES AND INFECTION (2003)

Article Multidisciplinary Sciences

Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest

RA Fratti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

From genomics to proteomics

M Tyers et al.

NATURE (2003)

Review Microbiology

Innate immunity to Mycobacterium tuberculosis

R van Crevel et al.

CLINICAL MICROBIOLOGY REVIEWS (2002)

Article Pathology

Granulomatous diseases

P Kaye

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2000)

Article Immunology

Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis

PJ Cardona et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2000)

Article Cell Biology

Restraining mycobacteria: Role of granulomas in mycobacterial infections

BM Saunders et al.

IMMUNOLOGY AND CELL BIOLOGY (2000)

Review Medicine, General & Internal

A clinicopathological classification of granulomatous disorders

DG James

POSTGRADUATE MEDICAL JOURNAL (2000)