期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.877005
关键词
group 2 innate lymphoid cells; type 2 inflammation; tissue residency; recruitment; migration
类别
资金
- Canadian Institutes of Health Research [GR018902]
- Knut and Alice Wallenberg Foundation [2019.0221]
Group 2 innate lymphoid cells (ILC2s) are present in mucosal and non-mucosal tissues in both mice and humans, and are involved in initiating type 2 inflammation. Recent studies have shown that ILC2s have the ability to circulate between different organs during inflammation and may play roles in mediating multiple type 2 diseases.
Group 2 innate lymphoid cells (ILC2s) are present in both mouse and human mucosal and non-mucosal tissues and implicated in initiating type 2 inflammation. ILC2s are considered to be tissue resident cells that develop in the perinatal period and persist throughout life with minimal turning over in adulthood. However, recent studies in animal models have shown their ability to circulate between different organs during inflammation and their potential functions in the destined organs, suggesting their roles in mediating multiple type 2 diseases. Here, we review recent findings on ILC2 migration, including migration within, into and out of tissues during inflammation.
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