4.8 Review

Epigenetic Underpinnings of Inflammation: A Key to Unlock the Tumor Microenvironment in Glioblastoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

IL-33 induces ADAMTS5 expression and cell migration in glioblastoma multiforme

Dilara Akcora-Yildiz et al.

Summary: The study revealed significantly elevated mRNA expressions of IL-33 and ADAMTS5 in GBM cells, with a positive correlation between the two. IL-33 treatment increased ADAMTS5 protein levels in a dose-dependent manner and promoted migration of GBM cells.

MEDICAL ONCOLOGY (2022)

Article Oncology

Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition

Rohit Rao et al.

Summary: This study identified functionally distinct TAM subpopulations in different glioma subtypes, showing varied responses to TAM targeting. Particularly, proneural tumors exhibited significant inhibition with CSF1R inhibition, while mesenchymal tumors showed potential responsiveness to combined anti-angiogenic therapy and CSF1R inhibition.

NEURO-ONCOLOGY (2022)

Review Cell Biology

Inflammation and Myeloid Cells in Cancer Progression and Metastasis

Jenying Deng et al.

Summary: Most immunotherapy drugs target T cell surface proteins to enhance their tumor-killing activity, but this approach has limited success in certain solid tumors. Myeloid-related innate immunity plays a role in tumor progression and understanding this field may lead to new therapeutic options. Myeloid cells can differentiate into pro-inflammatory or anti-inflammatory forms depending on the tumor microenvironment. In this review, the relationship between cancer cells and myeloid cells in the tumor immune microenvironment, and the development of immunotherapeutic strategies targeting myeloid-related innate immunity will be discussed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Neurosciences

Sequential changes in histone modifications shape transcriptional responses underlying microglia polarization by glioma

Marta Maleszewska et al.

Summary: Microglia pre-exposed to glioma-conditioned medium acquire a transcriptional memory and display reduced expression of inflammatory genes after re-stimulation. Epigenetic mechanisms contribute to glioma-induced transcriptional memory in microglia, resulting in a tumor-supportive phenotype. GCM induces distinct histone modifications in microglia, with Hdac inhibitors blocking these changes and restoring inflammatory responses.
Article Oncology

ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment

Feng Dong et al.

Summary: This study reveals that hypoxia-induced upregulation of m(6)A demethylase ALKBH5 leads to the formation of NEAT1-mediated paraspeckles, resulting in increased CXCL8/IL8 expression and enhanced TAM recruitment and tumor progression in GBM. The findings provide evidence for the link between hypoxia-induced epitranscriptomic changes and the formation of an immunosuppressive microenvironment.

CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

Matthias Gromeier et al.

Summary: The study found that low tumor mutation burden is associated with longer survival after immunotherapy in recurrent glioblastoma patients, and this relationship is related to inflammatory gene signatures, which evolves upon recurrence.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Multispecific targeting of glioblastoma with tumor microenvironment-responsive multifunctional engineered NK cells

Jiao Wang et al.

Summary: This study demonstrates a promising strategy utilizing genetically engineered human NK cells as a multifunctional immunotherapy to target multiple mechanisms of GBM progression simultaneously, including addressing antigen escape, immunometabolic reprogramming, and immune cell homing.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Immunology

Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer

Gulcin Tezcan et al.

Summary: Our research suggests that NLRP3 activation using Nigericin could be a novel therapeutic approach to control the growth of tumors producing a low level of IL-1 beta and IL-18.

FRONTIERS IN IMMUNOLOGY (2021)

Article Cell Biology

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Lizhi He et al.

Summary: Macrophages undergoing M1 versus M2-type polarization exhibit significant differences in cell metabolism, cellular functions, and signaling pathways, especially in metabolic pathways. Drug screens have identified inhibitors that selectively block M2-type polarization, with MEK signaling being found necessary for M2-type polarization in a proof-of-principle study using comprehensive proteomics and phosphoproteomics datasets.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

Ester Gangoso et al.

Summary: In this study, it was found that GBM stem cells acquire the ability to evade immune clearance through epigenetic immunoediting, leading to the formation of an immunosuppressive tumor microenvironment. This process is not driven by genetic selection but by altering the transcriptional and epigenetic profile of GSCs after immune attack.
Article Biochemistry & Molecular Biology

p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition

Touseef Sheikh et al.

Summary: The research shows that inhibition of TLR4 in glioblastoma affects the expression of SOCS1, and this effect is dependent on the mutational status of p53.

CYTOKINE (2021)

Review Cell Biology

Epigenetic Signaling of Cancer Stem Cells During Inflammation

Zaoqu Liu et al.

Summary: Chronic inflammation activates signaling pathways through inflammatory cytokines, regulating the generation of CSCs via epigenetic mechanisms, with the mechanism still not fully elucidated. Understanding the relationship between inflammation and cancer stem cells is important for improving tumor treatment strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells

Kui Zhail et al.

Summary: The study identified brain-penetrant BACE1 inhibitors as regulators of macrophage-dependent phagocytosis in glioblastoma through IL-6-STAT3 signaling. Utilizing MK-8931 to reprogram pTAMs into sTAMs and promote macrophage phagocytosis, in combination with low-dose radiation, shows promising therapeutic efficacy in suppressing malignant growth in preclinical models. These findings suggest a potential streamline of BACE1 inhibitors for cancer therapy, offering a new approach to enhance macrophage-based therapy for malignant tumors.

NATURE CANCER (2021)

Article Medicine, Research & Experimental

Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment

Soohyun Hong et al.

Summary: The study demonstrated that EV-mediated miR-124 delivery exerted synergistic anti-tumor effects in human GBM cells by suppressing cell growth and inhibiting M2 microglial polarization.

THERANOSTICS (2021)

Article Oncology

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma

Krishanthan Vigneswaran et al.

Summary: The study reveals that YAP and TAZ are highly expressed in EGFR-amplified/mutant human GBMs, leading to the survival and proliferation of tumor cells. The benzoporphyrin derivative verteporfin induces apoptosis of EGFR-amplified/mutant GBM cells and shows significant efficacy in inhibiting tumor growth.

CLINICAL CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Claudia Foray et al.

Summary: The study aimed to monitor temozolomide (TMZ) treatment response and therapy-induced changes in the inflammatory tumor microenvironment (TME). The results showed that TMZ therapy significantly modified the spatial distribution and uptake of both tracers, with [F-18]FET uptake significantly reduced after therapy and a significant increase in [F-18]DPA-714 uptake in specific areas of the tumor.

THERANOSTICS (2021)

Article Oncology

SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling

Huikai Zhang et al.

Summary: The study demonstrates that SAA1 is up-regulated in GBM and its high expression indicates poor prognosis, promoting GBM cell death by regulating apoptosis. Gliomas with low SAA1 expression show increased sensitivity to TMZ, suggesting SAA1 as a regulator of cell apoptosis and a novel biomarker for glioma sensitivity to TMZ.

JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

Jing-Yiing Wu et al.

MOLECULAR CELL (2020)

Article Biotechnology & Applied Microbiology

Prognostic Correlation of Autophagy-Related Gene Expression-Based Risk Signature in Patients with Glioblastoma

Qiang-Wei Wang et al.

ONCOTARGETS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma

Carlos DeOcesano-Pereira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment

Anaelle A. Dumas et al.

EMBO JOURNAL (2020)

Review Oncology

Management of glioblastoma: State of the art and future directions

Aaron C. Tan et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Immunology

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma

Syreeta DeCordova et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models

Trang Thi Thu Nguyen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Oncology

E2F7-EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression

Rui Yang et al.

BRITISH JOURNAL OF CANCER (2020)

Review Biochemistry & Molecular Biology

The CNS and the Brain Tumor Microenvironment: Implications for Glioblastoma Immunotherapy

Fiona A. Desland et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma

Inbar Angel et al.

ONCOGENE (2020)

Review Biochemistry & Molecular Biology

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors

Marjolein M. G. Kes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Editorial Material Immunology

The hypoxia-lactate axis tempers inflammation

Lionel B. Ivashkiv

NATURE REVIEWS IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma

Luqing Tong et al.

THERANOSTICS (2020)

Review Oncology

MGMT Status as a Clinical Biomarker in Glioblastoma

Madison Butler et al.

TRENDS IN CANCER (2020)

Review Oncology

Brain immunology and immunotherapy in brain tumours

John H. Sampson et al.

NATURE REVIEWS CANCER (2020)

Review Oncology

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases

Costas D. Arvanitis et al.

NATURE REVIEWS CANCER (2020)

Article Biochemistry & Molecular Biology

TP53 gain-of-function mutation promotes inflammation in glioblastoma

Seok Won Ham et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Oncology

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

William Tomaszewski et al.

CLINICAL CANCER RESEARCH (2019)

Article Oncology

Epigenetic modulation of metabolism in glioblastoma

Zhen Dong et al.

SEMINARS IN CANCER BIOLOGY (2019)

Article Oncology

The miR155HG/miR-185/ANXA2 loop contributes to glioblastoma growth and progression

Weining Wu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Combined Inhibition of HDAC and EGFR Reduces Viability and Proliferation and Enhances STAT3 mRNA Expression in Glioblastoma Cells

Marienela Buendia Duque et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2019)

Review Neurosciences

Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies

Marta Cenciarini et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

Pengfei Zhang et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

IL-1 Family Members in Cancer; Two Sides to Every Story

Kevin J. Baker et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Genetics & Heredity

An Inflammatory Landscape for Preoperative Neurologic Deficits in Glioblastoma

Amal Katrib et al.

FRONTIERS IN GENETICS (2019)

Review Oncology

Molecular targeted therapy of glioblastoma

Emilie Le Rhun et al.

CANCER TREATMENT REVIEWS (2019)

Review Biochemistry & Molecular Biology

PD-L1/PD-1 Axis in Glioblastoma Multiforme

Jakub Litak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Tumor microenvironment: Interactions and therapy

Masoud Najafi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

IL-33/ST2 axis promotes glioblastoma cell invasion by accumulating tenascin-C

Jian-fei Zhang et al.

SCIENTIFIC REPORTS (2019)

Letter Oncology

Drugging DNA repair to target T-ALL cells

Yashodhara Dasgupta et al.

LEUKEMIA & LYMPHOMA (2018)

Review Pharmacology & Pharmacy

Targeting Epigenetics in Cancer

Richard L. Bennett et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Review Cell Biology

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

Maria G. Daskalaki et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Clinical Neurology

Multidimensional communication in the microenvirons of glioblastoma

Marike L. Broekman et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Oncology

Glioblastoma-activated pericytes support tumor growth via immunosuppression

Isadora F. G. Sena et al.

CANCER MEDICINE (2018)

Review Clinical Neurology

Interactions between tumor-associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies

Mony Chenda Morisse et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2018)

Article Biochemistry & Molecular Biology

N6-methyladenine DNA Modification in Glioblastoma

Qi Xie et al.

Article Biotechnology & Applied Microbiology

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Dan Zhou et al.

GENOME BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Non-coding RNAs as drug targets

Masayuki Matsui et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Oncology

Tumor-associated macrophages: from basic research to clinical application

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Article Multidisciplinary Sciences

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Zhixun Dou et al.

NATURE (2017)

Article Cell Biology

NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma

Yang Jiang et al.

CELL COMMUNICATION AND SIGNALING (2017)

Article Biochemistry & Molecular Biology

Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation

Bozena Kaminska et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Review Genetics & Heredity

Lateral Thinking: How Histone Modifications Regulate Gene Expression

Moyra Lawrence et al.

TRENDS IN GENETICS (2016)

Article Oncology

Interleukin-33 in human gliomas: Expression and prognostic significance

Dorothee Gramatzki et al.

ONCOLOGY LETTERS (2016)

Article Multidisciplinary Sciences

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Kevin C. Johnson et al.

NATURE COMMUNICATIONS (2016)

Review Clinical Neurology

Glioblastoma: pathology, molecular mechanisms and markers

Kenneth Aldape et al.

ACTA NEUROPATHOLOGICA (2015)

Review Immunology

Cellular Metabolism and Macrophage Functional Polarization

Linnan Zhu et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2015)

Article Cell Biology

IL-1β microenvironment promotes proliferation, migration and invasion of human glioma cells

K. Fathima Hurmath et al.

CELL BIOLOGY INTERNATIONAL (2014)

Review Pharmacology & Pharmacy

Interleukins in glioblastoma pathophysiology: implications for therapy

Y. T. Yeung et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Review Medicine, Research & Experimental

Targeting lactate metabolism for cancer therapeutics

Joanne R. Doherty et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Oncology

Interferon regulatory factor 3 alters glioma inflammatory and invasive properties

Leonid Tarassishin et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

Article Biochemistry & Molecular Biology

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

Guang-Yuh Chiou et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

Editorial Material Oncology

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

Melody A. Swartz et al.

CANCER RESEARCH (2012)

Review Biochemistry & Molecular Biology

Cancer Epigenetics: From Mechanism to Therapy

Mark A. Dawson et al.

Article Cell Biology

The tumor microenvironment at a glance

Frances R. Balkwill et al.

JOURNAL OF CELL SCIENCE (2012)

Article Medicine, Research & Experimental

Macrophage plasticity and polarization: in vivo veritas

Antonio Sica et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Oncology

Lactate: A Metabolic Key Player in Cancer

Franziska Hirschhaeuser et al.

CANCER RESEARCH (2011)

Review Biochemistry & Molecular Biology

Janus head: the dual role of HLA-G in CNS immunity

Yu-Hwa Huang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Review Dentistry, Oral Surgery & Medicine

Epigenetic Mechanisms in Inflammation

D. Bayarsaihan

JOURNAL OF DENTAL RESEARCH (2011)

Article Genetics & Heredity

Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma

Vivek Sharma et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Review Genetics & Heredity

Non-coding RNAs in human disease

Manel Esteller

NATURE REVIEWS GENETICS (2011)

Review Oncology

Epigenetic changes in gliomas

Rebecca Burgess et al.

CANCER BIOLOGY & THERAPY (2008)

Article Medicine, General & Internal

MGMT gene silencing and benefit from temozolomide in glioblastoma

ME Hegi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)