4.8 Article

IL-33 and IL-10 Serum Levels Increase in MCI Patients Following Homotaurine Treatment

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Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis

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Summary: Current disease-modifying drugs have limited efficacy in preventing disability progression in most multiple sclerosis patients, highlighting the need for new treatments. Research indicates that treatment with a BBB-permeable GABA(A)-R-specific agonist, homotaurine, can limit epitope spreading within the CNS, potentially offering therapeutic benefits for MS and other inflammatory disorders.

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