☆ 4.8 Review

The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

Peng Xu et al.

Summary: The study reveals that hypoxia-mediated YTHDF2 overexpression promotes cell proliferation and invasion in lung squamous cell carcinoma through activation of the mTOR/AKT signaling pathway, and YTHDF2 is closely associated with pN and pTNM stage, leading to poor prognosis for LUSC patients.

CANCER CELL INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

METTL3 promotes oxaliplatin resistance of gastric cancer CD133+stem cells by promoting PARP1 mRNA stability

Huafu Li et al.

Summary: In this study, the researchers investigated the mechanism of oxaliplatin resistance in gastric cancer using in vitro human gastric cancer organoids and oxaliplatin-resistant cell lines, as well as in vivo tumorigenicity experiments. They found that CD133+ stem cell-like cells are the main subpopulation associated with resistance, and that the gene PARP1 plays a central role in mediating this resistance. The researchers discovered that PARP1 can effectively repair DNA damage caused by oxaliplatin by activating the base excision repair pathway, leading to the development of drug resistance. They also found that CD133+ cells exhibit increased expression of the mRNA modification N6-methyladenosine (m6A) and its writer METTL3, which enhances the stability of PARP1 and contributes to its DNA damage repair ability. Overall, this study demonstrates that m6A methyltransferase METTL3 promotes oxaliplatin resistance in CD133+ gastric cancer stem cells by increasing PARP1 mRNA stability and base excision repair activity.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Biochemistry & Molecular Biology

METTL14-Mediated miR-30c-1-3p Maturation Represses the Progression of Lung Cancer via Regulation of MARCKSL1 Expression

Fei Li et al.

Summary: In this study, it was found that METTL14 promotes the maturation of miR-30c-1-3p and mediates the expression of MARCKSL1 to inhibit the progression of lung cancer.

MOLECULAR BIOTECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Ziwen Pan et al.

Summary: This study reveals the significant role of circNEIL3 in promoting gliomagenesis and malignant progression, as well as in driving macrophage infiltration into the tumour microenvironment. CircNEIL3 may serve as a potential prognostic biomarker and therapeutic target for gliomas.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

Yiyang Hu et al.

Summary: This study established an ALKBH5-PKMYT1-IGF2BP3 regulation system in metastasis, providing a new therapeutic target for gastric cancer metastasis.

MOLECULAR CANCER (2022)

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Article Cell Biology

METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis

Rui Su et al.

Summary: METTL16 has dual functions as an m(6)A writer in the nucleus and a translation facilitator in the cytosol, promoting translation through direct interactions with ribosomal RNAs and eukaryotic initiation factors.

NATURE CELL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

KIAA1429 is a potential prognostic marker in colorectal cancer by promoting the proliferation via downregulating WEE1 expression in an m6A-independent manner

Ling Ma et al.

Summary: The study showed that KIAA1429 was significantly upregulated in colorectal cancer tissues and its high expression was associated with shorter overall survival. KIAA1429 promoted colorectal cancer cell proliferation by negatively regulating WEE1 expression, indicating its potential as a prognostic marker for CRC.

ONCOGENE (2022)

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Article Biochemistry & Molecular Biology

Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry

Sansi Xing et al.

Summary: Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which are equally abundant in healthy adult human brain. Aberrant splicing in Tau exon 10 can lead to imbalanced expression levels of 3 R- and 4 R-Tau, triggering toxic Tau aggregation, neuron dysfunction, and patient death in tauopathies. This study identifies hnRNPC as a regulator that promotes Tau exon 10 inclusion by interacting with U-tract motifs in introns 9 and 10 of Tau pre-mRNA, suggesting a potential therapeutic role for hnRNPC in progressive supranuclear palsy (PSP), a tauopathy.

RNA BIOLOGY (2022)

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Article Cell Biology

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases

Deobrat Dixit et al.

Summary: In this study, DPY30 was identified as an in vivo-specific glioblastoma dependency using in vivo genetic screening. By examining the chromatin characteristics of glioblastoma stem cells, DPY30 was found to regulate angiogenesis and hypoxia pathways critical for tumor growth. However, DPY30 was dispensable in vitro. Additionally, DPY30 was shown to regulate the downstream effector PDE4B, with the inhibitor rolipram preferentially targeting DPY30-expressing cells and impairing the growth of patient-derived xenograft tumors in mice.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Cell Biology

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner

Shicheng Sun et al.

Summary: This study reveals that NKAP acts as a suppressor of ferroptosis in glioblastoma cells by binding to m(6)A and promoting the splicing and maturation of SLC7A11 mRNA.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay

Guoqiang Zhang et al.

Summary: Maternal RNA degradation is crucial for embryogenesis and is regulated by maternal RNA-binding proteins. This study demonstrates that a subset of m6A-modified mRNAs can control the dynamics of RNA-granules, thereby contributing to maternal mRNA decay. The FMR1 protein has been found to preferentially bind mRNAs containing the AGACU motif marked with m6A, leading to efficient degradation of maternal mRNAs. These findings uncover a mechanism by which sequence-specific mRNAs instruct FMR1-RNP granules to switch between condensed and de-condensed states, ultimately influencing maternal mRNA decay and normal development.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner

Hengyu Chen et al.

Summary: The study revealed that YTHDF1 is overexpressed in breast cancer and positively correlated with tumor size, lymph node invasion, and distant metastasis. Depletion of YTHDF1 inhibited proliferation, invasion, and cell cycle of breast cancer cells, and promoted metastasis by targeting FOXM1. This YTHDF1/FOXM1 regulatory pathway may serve as a potential biomarker and therapeutic target for breast cancer.

CELL AND BIOSCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R)

Sheng Li et al.

Summary: This study investigated the function and mechanism of demethyltransferase FTO in prostate cancer (PCa). The results showed that FTO expression was decreased in PCa and its low expression was associated with clinical characteristics. Downregulation of FTO promoted the proliferation, migration, invasion, and tumor growth of PCa cells. Additionally, FTO could regulate the malignant phenotype of PCa cells by modulating the expression level of MC4R.

BIOENGINEERED (2022)

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Article Oncology

YTHDF2 Inhibits the Migration and Invasion of Lung Adenocarcinoma by Negatively Regulating the FAM83D-TGFβ1-SMAD2/3 Pathway

Teng Zhao et al.

Summary: YTHDF2 is upregulated in lung adenocarcinoma and inhibits the migration and invasion of lung cancer cells by regulating the FAM83D-TGF beta 1-pSMAD2/3 pathway.

FRONTIERS IN ONCOLOGY (2022)

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Article Cell Biology

Characterization of m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration in Ovarian Cancer

Yihong Luo et al.

Summary: This study investigated the correlation between RNA N6-methyladenosine (m6A) modification patterns and tumor microenvironment (TME) cell infiltration in ovarian cancer (OC). Three distinct m6A modification patterns were identified, and the m6Ascore was closely correlated with TME cell infiltration. Patients with lower m6Ascores had worse outcomes and combined evaluation of m6Ascore and tumor mutation burden improved risk stratification. Differences in response to immune checkpoint inhibitor treatment were observed between high and low m6Ascore groups.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Cell Biology

Application Progress of Organoids in Colorectal Cancer

Lianxiang Luo et al.

Summary: Colorectal cancer organoids provide an unprecedented opportunity for colorectal cancer research, as they accurately simulate tumor characteristics and predict drug response. They have great application potential, but also face limitations and challenges that can be overcome through integration with other technologies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer

Menglu Dong et al.

Summary: The abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer. Three different m6A modification patterns were identified, and these patterns were consistent with the immune characteristics of the tumor microenvironment. The prognosis of patients could be predicted by evaluating the m6A modification pattern, and it also provided guidance for effective immunotherapy strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

The Role of m6A Regulator-Mediated Methylation Modification and Tumor Microenvironment Infiltration in Glioblastoma Multiforme

Liang Wang et al.

Summary: This study reveals the important role of m6A modifications in GBM tumor microenvironment (TME) cell infiltration and stemness characteristics. The m6A modification patterns are correlated with TME cell infiltration characteristics, stemness characteristics, tumor clinical outcome, immune infiltration, and stemness. Assessing the m6A modification pattern of individual tumors can enhance our understanding of TME infiltration and stemness characteristics and contribute to the development of immunotherapeutic strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Links Between N6-Methyladenosine and Tumor Microenvironments in Colorectal Cancer

Yundi Zhang et al.

Summary: Our study reveals a close association between m(6)A modification and TME formation. Evaluating m(6)A in cancer helps us understand the TME status, and targeting m(6)A in tumor cells may help modulate the TME and improve tumor therapy and immunotherapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

Comprehensive analysis of tumor immune microenvironment and prognosis of m6A-related lncRNAs in gastric cancer

Yi Wang et al.

Summary: The interplay between m6A modification and lncRNAs may play a critical role in predicting GC prognosis, sculpting TIME landscape, and predicting responses to ICIs therapy.

BMC CANCER (2022)

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Article Biochemistry & Molecular Biology

The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability

Nan Zhang et al.

Summary: Recent research has identified the overexpression of IGF2BP3, a protein, in the bone marrow of acute myeloid leukemia (AML) patients. This overexpression correlates with increased proliferation of leukemia cells and poor prognosis. IGF2BP3 stabilizes the activity of a cancer-related protein, promoting leukemia progression. Blocking IGF2BP3 expression reduces cell proliferation and impairs leukemic cell activity, making it a potential therapeutic target.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Sentinel Lymph Node Methods in Breast Cancer

Francesco Giammarile et al.

Summary: Breast cancer is the most common cancer in women worldwide, and sentinel lymph node biopsy is a highly reliable method for detecting lymph node metastasis. Despite some variations and differences, improved accuracy can be achieved with the accumulation of experience.

SEMINARS IN NUCLEAR MEDICINE (2022)

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Article Medicine, Research & Experimental

SMC1A regulated by KIAA1429 in m6A-independent manner promotes EMT progress in breast cancer

Xu Zhang et al.

Summary: The study revealed that KIAA1429 plays a significant role in promoting the migration and invasion of breast cancer cells, as well as in the regulation of breast cancer metastasis. Additionally, it was found that KIAA1429 directly binds to SMC1A mRNA and enhances its stability.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Medicine, Research & Experimental

SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner

Shouji Zhang et al.

Summary: This study explores the function of FTO, an m(6)A demethylase, in glioblastoma (GBM). The findings suggest that FTO downregulation is associated with higher glioma grades and poorer clinical outcomes. FTO inhibits GBM cell growth and invasion by regulating the m(6)A modification of pri-miR-10a. Additionally, the transcriptional activity of FTO is inhibited by SPI1, and treatment with the SPI1 inhibitor can restore FTO expression and decrease GBM tumor burden.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Immunology

N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in Glioblastoma

Wu Xiong et al.

Summary: This study reveals the important role of m6A modification patterns in shaping the tumor microenvironment of glioblastoma. The developed GM-score can identify individual patients' m6A modification patterns, enabling personalized and effective anti-tumor immunotherapy strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Clinical Neurology

Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders

Fan Chen et al.

Summary: The lymphatic system plays an important role in the circulatory system, with functions including immune defense, maintaining internal environment stability, and regulating tissue pressure. Recent studies have confirmed the presence of lymphatic vessels lined with endothelial cells in the CNS, particularly in the meninges. These discoveries have significant clinical implications for infectious diseases, autoimmunity, and tumor immunology.

FRONTIERS IN NEUROLOGY (2022)

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Review Oncology

The next wave of cellular immunotherapies in pancreatic cancer

Dannel Yeo et al.

Summary: Pancreatic cancer is a highly aggressive disease that is expected to become the second leading cause of cancer-related death worldwide. Current treatments for pancreatic cancer are limited, and cellular immunotherapy, particularly CAR T cell therapy, has shown limited efficacy. This review provides an overview of ongoing clinical studies and strategies to improve CAR T cell efficacy in pancreatic cancer.

MOLECULAR THERAPY-ONCOLYTICS (2022)

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Article Cell Biology

Prognostic Value of Genomic Instability of m6A-Related lncRNAs in Lung Adenocarcinoma

Rui Li et al.

Summary: We investigated the genomic instability features of m(6)A-related lncRNAs and identified their prognostic role in LUAD. We constructed a prognostic model and found that it could better predict the survival of LUAD patients. Additionally, we found that prognostic m(6)A-related lncRNAs played important roles in the tumor microenvironment, stemness scores, and anticancer drug sensitivity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Medicine, General & Internal

The Association of Lung Cancer and Sarcoidosis: A Systematic Review

Mirra Srinivasan et al.

Summary: This article explores the association between sarcoidosis and lung neoplasms and finds that they can coexist, although it is rare. Understanding this association can alter the diagnosis and treatment decisions.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway

Lin Zhang et al.

Summary: High expression of FTO in metastatic endometrial cancer promotes tumor metastasis and invasion both in vivo and in vitro by catalyzing demethylation modification in the 3'UTR region of HOXB13 mRNA, leading to activation of the WNT signaling pathway and downstream protein expression. Inhibitor ICG-001 targeting the WNT signaling pathway can block HOXB13 gene-induced tumor metastasis, suggesting a promising molecular intervention. This study sheds light on the relationship between obesity and endometrial cancer pathogenesis, highlighting future research directions.

RNA BIOLOGY (2021)

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Article Oncology

The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Deobrat Dixit et al.

Summary: Research reveals that m6A mRNA modifications are upregulated in glioblastoma stem cells, with the key m6A reader YTHDF2 stabilizing important transcripts such as MYC. Targeting the YTHDF2-MYC-IGFBP3 axis could potentially be a novel therapeutic approach for glioblastoma. Epitranscriptomics have the potential to reveal specific vulnerabilities in cancer cells that can be targeted for treatment.

CANCER DISCOVERY (2021)

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Review Pharmacology & Pharmacy

The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Yuehai Pan et al.

Summary: Dequalinium chloride has been shown to inhibit the growth of malignant tumors, especially glioblastoma, by targeting and accumulating in the mitochondria. This broad-spectrum antibiotic acts as an inhibitor of XIAP and holds potential in the treatment of malignant glioma by inducing cancer cell apoptosis.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2021)

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Review Oncology

RNA m6A methylation regulators in ovarian cancer

Jialu Guo et al.

Summary: m6A modification plays a vital role in various diseases, particularly in tumors. Changes in m6A levels and dysregulation of m6A regulators in ovarian cancer can impact disease development and prognosis. Therefore, studying m6A modification and its regulators is crucial for understanding and treating ovarian cancer.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells

Xiaolong Zhu et al.

Summary: Utilizing bioinformatics, it was found that the ESCRT subunit VPS25 is highly expressed in glioma tissues and correlates with poor prognosis, with knockdown of VPS25 inhibiting glioma cell proliferation and promoting apoptosis. VPS25 may affect glioma growth by mediating cell cycle and the JAK-STAT signaling pathway.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5

Dan Zhou et al.

Summary: The study revealed that the high expression of METTL3 in CRC promotes tumor growth and metastasis by suppressing YPEL5 expression. This provides a new strategy for the diagnosis and treatment of CRC.

MOLECULAR ONCOLOGY (2021)

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Article Multidisciplinary Sciences

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Runping Fang et al.

Summary: In this study, it was revealed that YTHDF2 overexpression is associated with poor prognosis in glioma patients due to EGFR-induced protein stabilization, leading to reduced cholesterol homeostasis and promoting GBM tumorigenesis through an RNA m6A methylation dependent mechanism.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Wilms' tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences

Keiko Horiuchi et al.

Summary: The WTAP complex regulates alternative splicing by promoting exon skipping and intron retention, especially in AS events involving short introns/exons with higher GC content and weaker polypyrimidine-tract and branch points. Additionally, the interaction between WTAP and CBLL1 facilitates the recruitment of the 30-end processing complex, indicating an inhibitory mechanism in GC-rich sequences for AS and alternative polyadenylation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Cell Biology

WTAP facilitates progression of endometrial cancer via CAV-1/NF-κB axis

Qin Li et al.

Summary: The high expression of WTAP in endometrial cancer leads to increased proliferation, migration, and invasion of cells, decreased apoptosis, and higher tumor malignancy. Knocking down WTAP in EC cells results in upregulation of CAV-1, decrease in m(6)A and METTL3 enrichment at the 3' -UTR of CAV-1, and inhibition of NF-kappa B signaling pathway activity.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Multidisciplinary Sciences

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Huilong Yin et al.

Summary: The study reveals that deletion of Mettl3 in myeloid cells promotes tumor growth and metastasis, as well as affecting the efficacy of PD-1 checkpoint blockade therapy.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Alexander H. Lee et al.

Summary: The authors conducted a high-dimensional analysis of the immune landscape in glioblastoma patients following neoadjuvant PD-1 blockade, revealing an increase in T cell infiltration and a population of progenitor exhausted T cells within the tumor. The study also identified changes in dendritic cells and myeloid cells following PD-1 blockade, suggesting the need for targeting these cells in future immunotherapeutic strategies for clinical benefit.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma

Yi Jin et al.

Summary: The study highlights the significant role of m6A regulators in adrenocortical carcinoma (ACC), showing distinct m6A patterns associated with clinical outcomes and tumor immune microenvironment. By establishing a prognostic model and validating key modifications, the study reveals the potential importance of m6A modifications in ACC development and prognosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

RNA N6-Methyladenosine Regulator-Mediated Methylation Modifications Pattern and Immune Infiltration Features in Glioblastoma

Yimin Pan et al.

Summary: This study investigated the relationship between m(6)A methylation modification patterns and immune cell infiltration in GBM, identifying two distinct clusters with diverse m(6)A modification characteristics. The constructed MPAP based on these characteristics can quantitatively predict the prognosis of GBM patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

The role of N6-methyladenosine mRNA in the tumor microenvironment

Min Li et al.

Summary: The widely studied N6-methyladenosine (m6A) modification of mRNA has shown conflicting effects on tumor progression. In addition to its impact on tumor cells, m6A mRNA also plays a crucial role in stromal cells within the tumor microenvironment.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Immunology

Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer

Yongdong Guo et al.

Summary: This study demonstrated that m6A regulators modulate the immune microenvironment of PAAD, with risk scores serving as predictive indicators for immunotherapy and playing a prognostic role for PAAD patients. The research also provided novel therapeutic targets to improve immunotherapy efficacy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia

Ashuai Du et al.

Summary: This study investigated the impact of RNA N6-methyladenosine (m6A) modifications on tumor microenvironment cell infiltration in myeloid leukemia. Three distinct m6A modification patterns were identified, corresponding with different immunophenotypes of tumors: immunorejection, immune activation, and immune inertness. The study found that m6A modification patterns were associated with mutational burden, immune activation, survival rates, and antitumor immune responses, highlighting the potential of m6A regulators as targets for immune therapies in acute myeloid leukemia.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Non-Coding RNA m6A Modification in Cancer: Mechanisms and Therapeutic Targets

Da-Hong Chen et al.

Summary: This review discusses the relationship between non-coding RNA m6A modification and cancer progression from the perspective of various cancers, focusing on important mechanisms such as proliferation, apoptosis, invasion and metastasis, tumor angiogenesis. Clinical applications are introduced to illustrate the broad research prospects of non-coding RNA m6A modification in cancer research.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Characterization of the Prognostic m6A-Related lncRNA Signature in Gastric Cancer

Haixu Wang et al.

Summary: This study identified 11 m(6)A-related lncRNA signatures and demonstrated their ability to independently predict overall survival and disease-free survival in gastric cancer patients. The findings also suggest that patient risk groups are associated with different biological pathways, which may impact their treatment response.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy

Jian Hu et al.

Summary: YTHDF1 is implicated in human cancers with potential as a prognostic and immunological biomarker across cancer types. It plays a crucial role in the tumor microenvironment, immune regulation, and has associations with prognosis, immune checkpoints, and tumor mutational burden. YTHDF1 may serve as a novel target for tumor immunotherapy.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d

Honggui Ma et al.

Aging-US (2021)

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Article Oncology

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

Lihui Dong et al.

Summary: The study reveals that the m(6)A methyltransferase Mettl14 in TAMs plays a role in modulating the function of CD8(+) T cells by regulating C1q(+) TAMs, ultimately affecting tumor progression.

CANCER CELL (2021)

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Article Biotechnology & Applied Microbiology

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration

Kuan Hu et al.

Summary: Expression profiles of the YTH family were dysregulated in LUAD, with lower expression of YTHDC1 and YTHDC2 and higher expression of YTHDF1, YTHDF2, and YTHDF3. Lower expression of YTHDC2, YTHDF1, and YTHDF2 was associated with better overall survival in LUAD patients, suggesting potential therapeutic targets.

DISEASE MARKERS (2021)

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Article Cell Biology

The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan-cancer

Chiyuan Zhang et al.

Summary: YTHDC2 plays a significant role in cancer, with different mutations and methylation levels affecting patient prognosis; its main molecular mechanisms include catalytic activity and helicase activity. Additionally, YTHDC2 is closely associated with tumor immune infiltration and has high diagnostic value in seven types of cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Zhenchuan Liu et al.

Summary: In this study, it was found that circIGF2BP3 contributes to immune escape in NSCLC by upregulating PKP3 expression and stabilizing OTUB1 mRNA to increase PD-L1 abundance. The impact on the CD8(+) T cell response was observed, shedding light on a novel mechanism of PD-L1 regulation in NSCLC and providing insight on enhancing the efficacy of anti-PD-1 treatment.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

ALKBH5 Promotes the Proliferation of Glioma Cells via Enhancing the mRNA Stability of G6PD

Zhifeng Liu et al.

Summary: This study revealed that the upregulation of ALKBH5 in glioma promotes cell proliferation by demethylating G6PD and enhancing PPP activity. ALKBH5 could serve as a potential therapeutic target for glioma.

NEUROCHEMICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

A comprehensive review of m6A/m6Am RNA methyltransferase structures

Stephanie Oerum et al.

Summary: Gene expression is regulated through various levels, including chemical modifications on RNA during or after transcription. One such modification is N6-methylation, which affects the structure, stability, degradation, and cellular interactions of the modified RNA, with dysregulation linked to multiple human cancers.RNA methyltransferases are the enzymes responsible for these modifications, and structural characterization of these enzymes is critical for understanding their functions.

NUCLEIC ACIDS RESEARCH (2021)

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Article Immunology

Characterization of the m6A-Associated Tumor Immune Microenvironment in Prostate Cancer to Aid Immunotherapy

Zezhen Liu et al.

Summary: This study identified three distinct m6A regulation patterns in PCa, each with specific characteristics related to patient prognosis and tumor immune microenvironment. Among these patterns, patients in the low-m6Ascore group were more likely to benefit from ICIs therapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity

Jing Zhou et al.

Summary: The m(6)A eraser ALKBH5 plays a crucial role in controlling the pathogenicity of CD4(+) T cells during autoimmunity, as its deficiency results in weakened immune responses and reduced recruitment of neutrophils into the central nervous system.

SCIENCE ADVANCES (2021)

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Article Oncology

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m(6)A Dependent Manner

Jia Shi et al.

Summary: The study found that METTL3-mediated m(6)A modification was significantly elevated in TMZ-resistant GBM cells, impairing TMZ-sensitivity. Manipulation of METTL3 expression or methylation inhibition improved the sensitivity of TMZ-resistant GBM cells. Additionally, METTL3-modified DNA repair genes play a crucial role in GBM resistance to TMZ.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Landscape of Prognostic m6A RNA Methylation Regulators in Hepatocellular Carcinoma to Aid Immunotherapy

Qianhui Xu et al.

Summary: This study explored the tumor immune microenvironment in hepatocellular carcinoma using bioinformatics analyses and identified two different HCC categories related to m6A. A risk signature showed robust prognostic validity and correlation with the immune context. Patients with low-risk scores had significantly higher immunophenoscores based on IPS evaluation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Interplay of m6A and histone modifications contributes to temozolomide resistance in glioblastoma

Fuxi Li et al.

Summary: Our study identified that TMZ treatment upregulated the m(6)A methyltransferase METTL3, enhancing m(6)A modification of histone modification-related gene transcripts. METTL3 is crucial for maintaining GBM stem cell features, and its silencing in combination with TMZ inhibited orthotopic TMZ-resistant xenograft growth.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR-302a

Chuanhong Zhong et al.

Summary: JMJD1C is found to be poorly expressed in glioma tissues, and it increases miR-302a expression by promoting H3K9me1 demethylation, thereby inhibiting the growth of glioma. JMJD1C promotes M1 macrophage polarization through the miR-302a/METTL3/SOCS2 axis, potentially serving as a novel targeted therapeutic approach for glioma.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

ELAVL1 primarily couples mRNA stability with the 3′ UTRs of interferon-stimulated genes

Katherine Rothamel et al.

Summary: Research has shown that ELAVL1 transitions its binding sites upon cell immune stimulation and mediates RNA stability of genes regulating pathogen sensing and cytokine production pathways.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Qing Li et al.

Summary: YTHDF1 plays a key role in hepatocellular carcinoma, with its expression level correlated to hypoxia-induced autophagy, tumor growth, and metastasis, serving as an independent prognostic factor. HIF-1 alpha regulates YTHDF1 transcription under hypoxia to promote translation of autophagy-related genes, contributing to autophagy and malignancy in HCC progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

The role of m6A modification in the biological functions and diseases

Xiulin Jiang et al.

Summary: This paper highlights the importance of m6A RNA modification in eukaryotic RNA, including the roles of m6A methyltransferases, demethylases, and binding proteins. It emphasizes the crucial role of m6A RNA modification in the development of human cancers and discusses its impact on the physiological and pathological progressions of hematopoietic, central nervous, and reproductive systems.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p

Jianxing Yin et al.

Summary: The study found that EVs from hypoxic GSCs exerted a greater impact on GBM chemoresistance, with significantly upregulated miR-30b-3p. HIF1 alpha and STAT3 transcriptionally induced miR-30b-3p expression, while hnRNPA2B1 facilitated its transfer into EVs, targeting RHOB and reducing apoptosis while promoting proliferation in vitro and in vivo. The findings suggest that targeting EV-miR-30b-3p could be a potential treatment strategy for GBM.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression

Lin Zhang et al.

Summary: This study reveals a crucial role of IGF2BP1 in the m(6)A-dependent regulatory mechanism in endometrial cancer, shedding light on disease progression and potential biological functions.

THERANOSTICS (2021)

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Article Cell Biology

Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer

Tong Liu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Genetics & Heredity

N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2

Hong Wang et al.

GENE (2020)

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Article Gastroenterology & Hepatology

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

Qiang Wang et al.

GUT (2020)

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Article Biotechnology & Applied Microbiology

被撤回的出版物: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing (Retracted article. See vol. 30, pg. 2640, 2022)

Xiaoxiang Chen et al.

MOLECULAR THERAPY (2020)

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Article Biochemistry & Molecular Biology

ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

Yinghui Chao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB

Sasithorn Wanna-udom et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

Xiaoge Hu et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biochemistry & Molecular Biology

Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

Yue Hu et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Oncology

M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Xueliang Zuo et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Bo Tang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

Tao Liu et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Clinical Neurology

Dequalinium chloride inhibits the growth of human glioma cells in vitro and vivo: a study on molecular mechanism and potential targeted agents

Ying Yu et al.

ACTA NEUROCHIRURGICA (2020)

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Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

The potential role of RNA N6-methyladenosine in Cancer progression

Tianyi Wang et al.

MOLECULAR CANCER (2020)

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Article Biotechnology & Applied Microbiology

Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis

Zhenyao Chen et al.

MOLECULAR THERAPY (2020)

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Article Biochemistry & Molecular Biology

YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation

Chuanzhao Zhang et al.

ONCOGENE (2020)

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Review Oncology

The biological function of m6A demethylase ALKBH5 and its role in human disease

Jinyan Wang et al.

CANCER CELL INTERNATIONAL (2020)

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Article Cell & Tissue Engineering

The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells

Qian Gao et al.

STEM CELLS INTERNATIONAL (2020)

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Article Genetics & Heredity

Gene Signature and Identification of Clinical Trait-Related m6A Regulators in Pancreatic Cancer

Jie Hou et al.

FRONTIERS IN GENETICS (2020)

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Review Medicine, Research & Experimental

Role of m6A RNA methylation in cardiovascular disease (Review)

Yuhan Qin et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Review Oncology

m6A modification in RNA: biogenesis, functions and roles in gliomas

Yuhao Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Oncology

Circular RNAs: Novel biomarkers for cervical, ovarian and endometrial cancer

Yuchuan Shi et al.

ONCOLOGY REPORTS (2020)

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Article Cell Biology

N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification

Qianqing Wang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

Guoqiang Chang et al.

CANCER CELL (2020)

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Article Genetics & Heredity

Expression and Prognostic Characteristics of m6 A RNA Methylation Regulators in Breast Cancer

Bo Zhang et al.

FRONTIERS IN GENETICS (2020)

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Article Cell Biology

EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma

Bin Qi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell & Tissue Engineering

N6-methyladenosine (m6A)RNAmodification in cancer stem cells

Zhonghua Ma et al.

STEM CELLS (2020)

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Article Oncology

Expression Status And Prognostic Value Of M6A-associated Genes in Gastric Cancer

Kelei Guan et al.

JOURNAL OF CANCER (2020)

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Article Cell Biology

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Huiwen Song et al.

AUTOPHAGY (2019)

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Article Biochemistry & Molecular Biology

The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA

Jie Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression updates through inhibiting BNIP3

Yi Niu et al.

MOLECULAR CANCER (2019)

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Article Medicine, General & Internal

METTL3 promotes the proliferation and mobility of gastric cancer cells

Sen Lin et al.

OPEN MEDICINE (2019)

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Article Biochemistry & Molecular Biology

METTL3 mediated m6A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating ΔNp63

Renpeng Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Cell & Tissue Engineering

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Jasmin Paris et al.

CELL STEM CELL (2019)

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Review Biochemistry & Molecular Biology

The role of m6A RNA methylation in human cancer

Xiao-Yu Chen et al.

MOLECULAR CANCER (2019)

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Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

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Article Multidisciplinary Sciences

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang et al.

NATURE COMMUNICATIONS (2019)

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Review Physiology

LRPPRC: A Multifunctional Protein Involved in Energy Metabolism and Human Disease

Jie Cui et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Oncology

YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma

Yang Bai et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Jie Han et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Ting Li et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

Xinyao Lin et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Yunhao Chen et al.

MOLECULAR CANCER (2019)

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Review Oncology

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Ben Yue et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

Jiajie Hou et al.

MOLECULAR CANCER (2019)

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Article Genetics & Heredity

Integrated analysis of transcriptome-wide m6A methylome of osteosarcoma stem cells enriched by chemotherapy

Yongjie Wang et al.

EPIGENOMICS (2019)

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Article Oncology

Knockdown of METTL14 inhibits the growth and invasion of cervical cancer

Feng Geng et al.

TRANSLATIONAL CANCER RESEARCH (2019)

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Review Oncology

Novel positioning from obesity to cancer: FTO, an m(6)A RNA demethylase, regulates tumour progression

JiaLing Chen et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

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Article Oncology

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Dan Jin et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

Maosheng Cheng et al.

ONCOGENE (2019)

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Article Biochemistry & Molecular Biology

m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5

Yi Zhang et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3

Tian Lan et al.

MOLECULAR CANCER (2019)

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Article Oncology

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells

Kosuke Taketo et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

A. Visvanathan et al.

ONCOGENE (2018)

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Article Biochemistry & Molecular Biology

m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

Jiqin Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Tathiane M. Malta et al.

CELL (2018)

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Letter Cell Biology

m6A mRNA methylation sustains Treg suppressive functions

Jiyu Tong et al.

CELL RESEARCH (2018)

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Article Cell & Tissue Engineering

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Hengyou Weng et al.

CELL STEM CELL (2018)

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Article Cell Biology

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

Yuan He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Cell Biology

Role of N6-methyladenosine modification in cancer

Xiaolan Deng et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)

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Article Oncology

Hepatocellular carcinoma in the era of immunotherapy

Hao-Wen Sim et al.

CURRENT PROBLEMS IN CANCER (2018)

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Article Gastroenterology & Hepatology

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

Mengnuo Chen et al.

HEPATOLOGY (2018)

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Article Biochemistry & Molecular Biology

Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

Jing Wen et al.

MOLECULAR CELL (2018)

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Article Cell Biology

Recognition of RNA N6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang et al.

NATURE CELL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex

Eva Schoeller et al.

RNA (2018)

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Review Cell Biology

Reading m6A in the Transcriptome: m6A-Binding Proteins

Deepak P. Patil et al.

TRENDS IN CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Baixing Wu et al.

NATURE COMMUNICATIONS (2018)

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Article Cell Biology

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Jun Liu et al.

NATURE CELL BIOLOGY (2018)

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Editorial Material Biochemistry & Molecular Biology

The emerging biology of RNA post-transcriptional modifications

Sigrid Nachtergaele et al.

RNA BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

Ly P. Vu et al.

NATURE MEDICINE (2017)

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Article Biochemistry & Molecular Biology

N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

Nian Liu et al.

NUCLEIC ACIDS RESEARCH (2017)

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Article Cell Biology

m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

Qi Cui et al.

CELL REPORTS (2017)

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Article Biology

YTHDC1 mediates nuclear export of N6 - methyladenosine methylated mRNAs

Ian A. Roundtree et al.

ELIFE (2017)

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Review Hematology

Molecular biomarkers in acute myeloid leukemia

Jeanette Prada-Arismendy et al.

BLOOD REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs

Ahmed S. Warda et al.

EMBO REPORTS (2017)

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Article Cell Biology

Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis

Phillip J. Hsu et al.

CELL RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

CELL (2017)

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Article Oncology

m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

Sicong Zhang et al.

CANCER CELL (2017)

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Article Oncology

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase

Zejuan Li et al.

CANCER CELL (2017)

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Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

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Article Biochemistry & Molecular Biology

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

Ping Wang et al.

MOLECULAR CELL (2016)

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Article Multidisciplinary Sciences

m6A RNA methylation promotes XIST-mediated transcriptional repression

Deepak P. Patil et al.

NATURE (2016)

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Editorial Material Biochemistry & Molecular Biology

N6-methyladenosine-encoded epitranscriptomics

Nian Liu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Editorial Material Biochemistry & Molecular Biology

N6-methyladenosine-encoded epitranscriptomics

Nian Liu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Article Multidisciplinary Sciences

N6-methyladenosine marks primary microRNAs for processing

Claudio R. Alarcon et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Structural imprints in vivo decode RNA regulatory mechanisms

Robert C. Spitale et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

Kate D. Meyer et al.

CELL (2012)

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Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

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