☆ 4.8 Review

Role of Basophils in a Broad Spectrum of Disorders

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Allergy

The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine

Marina Labella et al.

Summary: The real-world incidence of hypersensitivity reactions to the BNT162b2 mRNA COVID-19 vaccine was evaluated, and the basophil activation test (BAT) was found to have potential diagnostic value for confirming allergy to the PEG excipient. Positive BAT results to the vaccine may indicate a past COVID-19 infection rather than an allergy.

ALLERGY (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 Induces Cytokine Responses in Human Basophils

Srinivasa Reddy Bonam et al.

Summary: This study reports that SARS-CoV-2 induces cytokine responses, particularly IL-13, in both resting and IL-3 primed basophils. However, the expression of surface markers associated with basophil activation and PD-L1 expression on basophils are not affected by SARS-CoV-2. The results suggest that basophil cytokine responses to SARS-CoV-2 might help reduce inflammation and promote antibody responses to the virus.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Cell Biology

Clinical and Translational Significance of Basophils in Patients with Cancer

Jitesh Chauhan et al.

Summary: Basophils, despite their small proportion in circulating blood leukocytes, play significant roles as potent immune effector cells. They express high-affinity receptors for IgE and store powerful inflammatory mediators ready to be secreted. They are implicated in allergic diseases, hypersensitivity reactions, chronic inflammation, and responses to infections. Despite their activation by Th2-biased signals, which are also observed in certain tumors, basophils have been neglected in cancer research. This article discusses the presence and functional significance of basophils in cancer patients and the tumor microenvironment, exploring gene expression analyses and the potential use of basophil activation test (BAT) to predict hypersensitivity to cancer treatments and monitor patient desensitization.

CELLS (2022)

添加到收藏夹

Article Immunology

Elastase- and LPS-Exposed Cpa3Cre/+ and ST2-/- Mice Develop Unimpaired Obstructive Pulmonary Disease

Eduardo Cardenas et al.

Summary: The ST2 receptor and mast cells play a minor role in COPD pathophysiology as they sustain alveolar macrophages.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Allergy

Basophil sensitivity reflects long-term clinical outcome of subcutaneous immunotherapy in grass pollen-allergic patients

Johannes M. Schmid et al.

Summary: The study showed that subcutaneous immunotherapy for allergic rhinoconjunctivitis led to a significant decrease in basophil sensitivity, which predicted long-term treatment outcomes. Additionally, changes in antibody biomarkers were associated with cellular changes in nasal mucosa.

ALLERGY (2021)

添加到收藏夹

Letter Allergy

A very low number of circulating basophils is predictive of a poor response to omalizumab in chronic spontaneous urticaria

Matija Rijavec et al.

ALLERGY (2021)

添加到收藏夹

Article Biology

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

Kia Joo Puan et al.

Summary: The researchers found that FUT6 deficiency results in the loss of the tetrasaccharide sLex on the surface of basophils, causing cells to be less sticky and therefore less able to form the necessary adhesions to drive the allergic reaction.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Review Allergy

Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice

Alexandra F. Santos et al.

Summary: The basophil activation test (BAT) measures the degree of degranulation of basophils following stimulation with allergen, and it can be used as a more specific diagnostic tool for allergic diseases. Clinical application of BAT requires clinical validation, quality assurance, and efforts are ongoing to establish a platform for laboratories to ensure reproducibility and reliability of results.

ALLERGY (2021)

添加到收藏夹

Review Allergy

Basophils and their effector molecules in allergic disorders

Kensuke Miyake et al.

Summary: Basophils are rare granulocytes that play crucial roles in allergic inflammation by releasing effector molecules to regulate immune responses and allergic disorders. They are recruited to inflamed tissues and activated in various ways, highlighting their versatile functions in the immune system.

ALLERGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A basophil-neuronal axis promotes itch

Fang Wang et al.

Summary: The study identifies that a large proportion of patients with atopic dermatitis (AD) harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. It also shows that in AD-associated inflammation, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares.

CELL (2021)

添加到收藏夹

Article Allergy

Basophils and IgE contribute to mixed connective tissue disease development

Yasmine Lamri et al.

Summary: MCTD is a rare and complex autoimmune disease with high levels of anti-U1 small nuclear ribonucleoprotein 70k autoantibodies. Basophils and IgE play a role in MCTD pathophysiology and may serve as therapeutic targets for patients. Basophil activation and autoreactive IgE against U1 small nuclear ribonucleoprotein 70k were observed in both patients and an MCTD-like mouse model.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Autoimmunity, IgE and FceRI-bearing cells

Nicolas Charles

Summary: Antibody-mediated autoimmune diseases involve various autoreactive antibodies, with IgE playing a significant role in some cases. Cells bearing FceRI, such as basophils or mast cells, are crucial in these diseases. Advancements in pathophysiology have led to the development of anti-IgE strategies that show promising effects in certain conditions.

CURRENT OPINION IN IMMUNOLOGY (2021)

添加到收藏夹

Letter Immunology

Basophils in autoimmunity: Systemic lupus erythematosus and more?

Dimitri Poddighe et al.

AUTOIMMUNITY REVIEWS (2021)

添加到收藏夹

Article Infectious Diseases

In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19*

Felipe Ten-Caten et al.

Summary: The study analyzed laboratory parameters of a large cohort of COVID-19 patients and identified the impact of sex and age on these parameters. Both male and female patients showed similar alterations in laboratory parameters, with older men displaying more significant increases in CRP and ferritin.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Allergy

Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab

Donald MacGlashan et al.

Summary: This study examined changes in basophil function and its relationship to auto-antibodies during treatment with omalizumab in patients with chronic spontaneous urticaria (CSU). Results suggest that the presence of auto-antibodies may affect basophil numbers and function in patients treated with omalizumab.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Letter Medicine, General & Internal

Rare Skin Reactions after mRNA Vaccination, Similar to Jones-Mote Basophil Responses

Philip W. Askenase

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Allergy

The efficacy of omalizumab treatment in chronic spontaneous urticaria is associated with basophil phenotypes

Kirti J. Johal et al.

Summary: The study suggests that the baseline basophil count and functional phenotype may predict responsiveness to omalizumab in treating chronic spontaneous urticaria. However, changes in basophil IgE-based histamine release, surface IgE, or Fc epsilon RI do not correlate with the kinetics of improvement in clinical symptoms during therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Allergy

Basophils promote barrier dysfunction and resolution in the skin

Christophe Pellefigues et al.

Summary: The study found that basophils play a key role in both promoting skin inflammation and participating in the resolution of inflammation in an AD model. Basophils and IL-4 promote epidermal hyperplasia and skin barrier dysfunction by acting on keratinocyte differentiation. They also inhibit the accumulation of proinflammatory cells in the skin while promoting the expansion and function of proresolution M2-like macrophages.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Allergy

Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma

Natasha A. Winter et al.

Summary: This study identified 8 MC/basophil-related genes in sputum and found correlations with eosinophilic inflammation, lung function, and exacerbation history in severe asthma. The gene signature may reflect variations in sputum MC/basophil abundance and their associations with clinical and inflammatory characteristics in severe asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Platelet parameters and leukocyte morphology is altered in COVID-19 patients compared to non-COVID-19 patients with similar symptomatology

Anne Alnor et al.

Summary: The study evaluated haematological and morphological parameters of COVID-19 infected patients compared to those without infection. Significant differences were found in platelet indices and white blood cell parameters between the two groups. Patients with severe disease course had higher levels of immature granulocytes and fewer lymphocytes and platelets. The results suggest platelets may play a fundamental role in the pathophysiology of COVID-19.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2021)

添加到收藏夹

Article Allergy

Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis

Shinya Imamura et al.

Summary: This study found that basophils in patients with atopic dermatitis exhibited spontaneous activation and lower responsiveness to anti-IgE stimulation compared to healthy controls, despite elevated levels of serum IgE. Additionally, Fc epsilon RI expression on basophils was higher in patients with atopic dermatitis than in healthy controls, while surface-bound IgE was relatively low.

ALLERGOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Health Care Sciences & Services

White Blood Cells and Severe COVID-19: A Mendelian Randomization Study

Yitang Sun et al.

Summary: The study reveals causal protective effects of higher basophil count, basophil percentage of white blood cells, and myeloid white blood cell count on severe COVID-19, but no association with COVID-19 severity or susceptibility was found. Individuals with a lower genetic capacity for basophils may be at risk, while enhancing basophil production could be an effective therapeutic strategy.

JOURNAL OF PERSONALIZED MEDICINE (2021)

添加到收藏夹

Article Allergy

Therapeutic Effects of Benralizumab Assessed in Patients with Severe Eosinophilic Asthma: Real-Life Evaluation Correlated with Allergic and Non-Allergic Phenotype Expression

Corrado Pelaia et al.

Summary: This multicenter observational investigation evaluated the therapeutic effects of benralizumab in patients with severe uncontrolled eosinophilic asthma, showing significant improvement in symptoms and quality of life after 6 months of treatment.

JOURNAL OF ASTHMA AND ALLERGY (2021)

添加到收藏夹

Article Allergy

CytoBas: Precision component-resolved diagnostics for allergy using flow cytometric staining of basophils with recombinant allergen tetramers

Craig I. McKenzie et al.

Summary: The newly developed CytoBas flow cytometric assay utilizes fluorescent protein tetramers to directly stain IgE on blood basophils, allowing for rapid and reliable detection of clinically relevant allergic sensitization. The method has a high positive predictive value for disease and can be multiplexed for component-resolved and differential diagnostic testing for allergy.

ALLERGY (2021)

添加到收藏夹

Article Oncology

Clinical Outcomes and Immune Metrics in Intratumoral Basophil-Enriched Gastric Cancer Patients

Xudong He et al.

Summary: The study revealed that tumor-infiltrating basophils in gastric cancer are an independent adverse prognosticator and predict inferior chemotherapeutic responsiveness, indicating the need for more individualized postoperative adjuvant therapy and stringent follow-up for these patients. Basophils abundance is associated with an immunoevasive tumor microenvironment, which could potentially be a target for immunotherapy in gastric cancer.

ANNALS OF SURGICAL ONCOLOGY (2021)

添加到收藏夹

Article Immunology

Serum CD203c+Extracellular Vesicle Serves as a Novel Diagnostic and Prognostic Biomarker for Succinylated Gelatin Induced Perioperative Hypersensitive Reaction

Zheng Qi et al.

Summary: This study investigated EVs isolated from serum in patients with succinylated gelatin induced HR, and found that the expression of CD203c in these EVs could serve as a potential diagnostic and prognostic biomarker for HR. This provides new insights for the diagnosis and prognosis of HR.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Allergy

Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis

Whitney W. Stevens et al.

Summary: The study found that the number of basophils in nasal polyps of AERD patients was significantly increased, along with ongoing degranulation, which may contribute to the disease pathogenesis and severity unique to AERD.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Allergy

Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy

Alexander Troelnikov et al.

Summary: Patients with a history of PEG allergy showed positive skin test results after receiving the BNT162b2 vaccine, while traditional PEG skin testing yielded negative results for 2 out of 3 patients. One patient exhibited cross-reactivity to PEG and polysorbate, leading to co-sensitization to both the BNT162b2 and AZD1222 vaccines.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Cell Biology

Basophils and Mast Cells in COVID-19 Pathogenesis

Giuseppe Murdaca et al.

Summary: Basophils play a crucial role in immune response to SARS-CoV-2 and their depletion may impact the antibody response, while mast cells participate in the initial immune response but their activation can lead to hyperinflammatory syndrome. Both basophil counts and mast cell activation could be important factors in the prognosis and treatment of COVID-19.

CELLS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection

Juan-Manuel Leyva-Castillo et al.

Summary: Research has shown that mechanical injury to mouse skin through tape stripping predisposes the skin to superficial infection with S. aureus. This infection is promoted by basophil-derived IL-4, which inhibits the production of IL-17A and facilitates S. aureus infection. IL-4 acts on multiple checkpoints to suppress the cutaneous IL-17A response, but blocking the IL-4 receptor can enhance Il17a expression and bacterial clearance.

JCI INSIGHT (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Eva Conde et al.

Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19

Magda Lourda et al.

Summary: This study utilized high-dimensional flow cytometry to analyze the immunophenotyping of granulocytes in COVID-19 patients, revealing increased levels of neutrophils and decreased counts of eosinophils and basophils in severe cases. Different immunotypes were associated with distinct sets of inflammatory markers and could predict key clinical features of the disease, suggesting potential value in clinical management.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Medicine, General & Internal

Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System

Christopher Michael Warren et al.

Summary: This study analyzed 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines, indicating a potential non-IgE mediated immune response to PEG in most individuals. Women and those with a history of allergic reactions may have an elevated risk of mRNA vaccine allergy.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Review Immunology

Basophils in antihelminth immunity

Jianya Peng et al.

Summary: Basophils are commonly associated with helminth infections and are known to contribute to immune responses by promoting optimal type 2 T helper cell reactions. However, recent studies have revealed that their effector functions are diverse and parasite-specific. Additionally, basophils can also regulate inflammation and maintain tissue integrity in helminth-infected individuals.

SEMINARS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Basophils balance healing after myocardial infarction via IL-4/IL-13

Florian Sicklinger et al.

Summary: The study show that basophils play a crucial role in promoting tissue repair after myocardial infarction by increasing levels of IL-4 and IL-13 in the heart. Depletion of basophils leads to an increase in inflammatory response, scar thinning, and deterioration of cardiac function post-MI.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia

Naofumi Mukaida et al.

Summary: Cancer stem cells play a crucial role in leukemia and various solid cancers, while less attention has been paid to cancer non-stem cells. Chronic myeloid leukemia stem cells generate a large number of non-stem cells, including basophils and megakaryocytes, and an increase in these non-stem cells is associated with poor prognosis.

MOLECULAR BIOMEDICINE (2021)

添加到收藏夹

Article Dermatology

IL-4R alpha Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis

Chris Callewaert et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

添加到收藏夹

Article Allergy

Decreased intracellular histamine concentration and basophil activation in anaphylaxis

Satoshi Yamaga et al.

ALLERGOLOGY INTERNATIONAL (2020)

添加到收藏夹

Letter Dermatology

Staphylococcus aureus Lipoteichoic Acid Initiates a TSLP-Basophil-IL4 Axis in the Skin

Anne M. Brauweiler et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

添加到收藏夹

Letter Allergy

Association of basophil parameters with disease severity and duration in chronic spontaneous urticaria (CSU)

Amy H. Huang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

添加到收藏夹

Article Allergy

Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation

Audrey Le Floc'h et al.

ALLERGY (2020)

添加到收藏夹

Article Immunology

Co-occurrence of IgE and IgG autoantibodies in patients with chronic spontaneous urticaria

R. Asero et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2020)

添加到收藏夹

Article Respiratory System

Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue

Prajakta Jogdand et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Article Allergy

Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE

Mindy Tsai et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation

Hiroki Kabata et al.

MUCOSAL IMMUNOLOGY (2020)

添加到收藏夹

Article Allergy

IgM and IgA in addition to IgG autoantibodies against FceRIα are frequent and associated with disease markers of chronic spontaneous urticaria

Sabine Altrichter et al.

ALLERGY (2020)

添加到收藏夹

Article Allergy

Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice

Yoshinori Yamanishi et al.

ALLERGY (2020)

添加到收藏夹

Article Biology

Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

Mark David Hayes et al.

ELIFE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

Gabsik Yang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Letter Allergy

Benralizumab strongly reduces blood basophils in severe eosinophilic asthma

Marek Lommatzsch et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Masutaka Furue

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Cell Biology

Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome

Heather J. Bax et al.

CELLS (2020)

添加到收藏夹

Review Cell Biology

Effects of omalizumab on basophils: Potential biomarkers in asthma and chronic spontaneous urticaria

Dimitri Poddighe et al.

CELLULAR IMMUNOLOGY (2020)

添加到收藏夹

Article Respiratory System

Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study

Takanori Numata et al.

BMC PULMONARY MEDICINE (2020)

添加到收藏夹

Article Immunology

A Granulocytic Signature Identifies COVID-19 and Its Severity

Joana Vitte et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Immunology

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Juan M. Inclan-Rico et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A dynamic COVID-19 immune signature includes associations with poor prognosis

Adam G. Laing et al.

NATURE MEDICINE (2020)

添加到收藏夹

Review Immunology

Is There a Role for Basophils in Cancer?

Giancarlo Marone et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Immunobiology of Acquired Resistance to Ticks

Hajime Karasuyama et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation

Yale Liu et al.

ISCIENCE (2020)

添加到收藏夹

Article Allergy

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

Romana Vantur et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

The role of haematological parameters in patients with COVID-19 and influenza virus infection

Sumeyye Kazancioglu et al.

EPIDEMIOLOGY AND INFECTION (2020)

添加到收藏夹

Article Immunology

Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice

Yu-Hsien Lin et al.

INTERNATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Article Cell Biology

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Lucie Rodriguez et al.

CELL REPORTS MEDICINE (2020)

添加到收藏夹

Article Allergy

Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils

Donald MacGlashan

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Allergy

Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman-Yassky et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Dermatology

Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice

Joerg U. Eberle et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

添加到收藏夹

Letter Allergy

Basophil count is a sensitive marker for clinical progression in a chronic spontaneous urticaria patient treated with omalizumab

Izumi Kishimoto et al.

ALLERGOLOGY INTERNATIONAL (2019)

添加到收藏夹

Letter Allergy

The basophil-IL-4-mast cell axis is required for food allergy

Jun-Ichi Kashiwakura et al.

ALLERGY (2019)

添加到收藏夹

Article Immunology

IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils

Saidou Balam et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Article Dermatology

IL-33-Induced Atopic Dermatitis-Like Inflammation in Mice Is Mediated by Group 2 Innate Lymphoid Cells in Concert with Basophils

Yasutomo Imai et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils

Soichiro Yoshikawa et al.

SCIENCE SIGNALING (2019)

添加到收藏夹

Article Dermatology

Long-term effects of omalizumab on peripheral blood cells and C-reactive protein levels in patients with chronic spontaneous urticaria

Neslihan Akdogan et al.

DERMATOLOGIC THERAPY (2019)

添加到收藏夹

Review Allergy

Pruritus in allergy and immunology

Ting-Lin B. Yang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils

Christophe Pellefigues et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Rheumatology

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus

Sarfaraz Hasni et al.

ARTHRITIS & RHEUMATOLOGY (2019)

添加到收藏夹

Article Allergy

IL-4 receptor a blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma

D. Russkamp et al.

ALLERGY (2019)

添加到收藏夹

Review Immunology

Autoimmune Theories of Chronic Spontaneous Urticaria

Sonali J. Bracken et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis

Masato Yanagawa et al.

JOURNAL OF GASTROENTEROLOGY (2018)

添加到收藏夹

Review Immunology

Human mast cells and basophils-How are they similar how are they different?

Gilda Varricchi et al.

IMMUNOLOGICAL REVIEWS (2018)

添加到收藏夹

Article Allergy

Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy

Maryam Hussain et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

添加到收藏夹

Review Dermatology

Recent advancement in the mechanism of basophil activation

Chisa Nakashima et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2018)

添加到收藏夹

Article Immunology

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

Greg Crawford et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs

Christophe Pellefigues et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

Georg Schett et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Allergy

Basophil Activation Test: Old and New Applications in Allergy

Oliver Hemmings et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages

Sho Shibata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Review Immunology

Mechanistic Insights into Autoimmune Pancreatitis and IgG4-Related Disease

Tomohiro Watanabe et al.

TRENDS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Type 2 immunity in tissue repair and fibrosis

Richard L. Gieseck et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Article Allergy

Systematic characterization of basophil anergy

Kia Joo Puan et al.

ALLERGY (2017)

添加到收藏夹

Article Oncology

Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells

Ibrahim M. Sektioglu et al.

CANCER RESEARCH (2017)

添加到收藏夹

Article Allergy

Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis

Peter Korosec et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Letter Allergy

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab

Donald W. MacGlashan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Letter Dermatology

Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria

Sarbjit S. Saini et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils

Kensuke Miyake et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of Fc epsilon RI-positive cells in the skin

Martin Metz et al.

THERANOSTICS (2017)

添加到收藏夹

Article Immunology

Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus

Qingjun Pan et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity

Chae Min Yuk et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Basophils contribute to pristane-induced Lupus-like nephritis model

Barbara Dema et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Allergy

Functional and phenotypic analysis of basophils allows determining distinct subtypes in patients with chronic urticaria

M. M. Rauber et al.

ALLERGY (2017)

添加到收藏夹

Article Allergy

Airway basophils are increased and activated in eosinophilic asthma

Y. Suzuki et al.

ALLERGY (2017)

添加到收藏夹

Article Allergy

Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes

C. R. Brooks et al.

ALLERGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

添加到收藏夹

Article Allergy

Human basophils are a source+ of - and are differentially activated by - IL-31

U. Raap et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

添加到收藏夹

Review Allergy

Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria

A. P. Kaplan et al.

ALLERGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

Tejaswini Kulkarni et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

添加到收藏夹

Article Surgery

Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development

G. Schiechl et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

添加到收藏夹

Article Hematology

MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice

Tomohisa Baba et al.

BLOOD (2016)

添加到收藏夹

Article Hematology

Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice

Misako Iki et al.

BLOOD (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Biological Basis for Cardiac Repair After Myocardial Infarction From Inflammation to Fibrosis

Sumanth D. Prabhu et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Article Allergy

Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice

Nicholas Venturelli et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Article Allergy

Timing and duration of omalizumab response in patients with chronic idiopathic/spontaneous urticaria

Allen Kaplan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Article Dermatology

Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression

Teruaki Nakatsuji et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

添加到收藏夹

Article Immunology

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

Daniel F. Dwyer et al.

NATURE IMMUNOLOGY (2016)

添加到收藏夹

Review Immunology

Role of basophils in protective immunity to parasitic infections

Joerg U. Eberle et al.

SEMINARS IN IMMUNOPATHOLOGY (2016)

添加到收藏夹

Review Immunology

Basophil-derived IL-4 plays versatile roles in immunity

Yoshinori Yamanishi et al.

SEMINARS IN IMMUNOPATHOLOGY (2016)

添加到收藏夹

Article Allergy

Correlation of basophil infiltration in nasal polyps with the severity of chronic rhinosinusitis

Ryoji Kagoya et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

Hideaki Morita et al.

IMMUNITY (2015)

添加到收藏夹

Article Immunology

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

Camille Bleriot et al.

IMMUNITY (2015)

添加到收藏夹

Article Immunology

Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis

Tetsuro Kobayashi et al.

IMMUNITY (2015)

添加到收藏夹

Article Immunology

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

Laurence E. Cheng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

添加到收藏夹

Article Dermatology

Basophil-Derived Amphiregulin Is Essential for UVB Irradiation-Induced Immune Suppression

Chantal Meulenbroeks et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

添加到收藏夹

Editorial Material Rheumatology

AUTOIMMUNITY Basophils in autoimmune and inflammatory diseases

Meenu Sharma et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

添加到收藏夹

Article Hematology

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

Efthymios Motakis et al.

BLOOD (2014)

添加到收藏夹

Article Immunology

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

Yasutaka Motomura et al.

IMMUNITY (2014)

添加到收藏夹

Article Immunology

The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

Taichiro Muto et al.

INTERNATIONAL IMMUNOLOGY (2014)

添加到收藏夹

Letter Allergy

Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity

Mahboobeh Mahdavinia et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis

Mario Noti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1

Ferda Cevikbas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis

Hongwei Han et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Immunology

Immunoglobulin E plays an immunoregulatory role in lupus

Barbara Dema et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

添加到收藏夹

Article Immunology

Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin

Brian S. Kim et al.

JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Medicine, General & Internal

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Lisa A. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis

Barbara Dema et al.

PLOS ONE (2014)

添加到收藏夹

Article Immunology

Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4

Mayumi Egawa et al.

IMMUNITY (2013)

添加到收藏夹

Review Dermatology

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

Kenji Kabashima

JOURNAL OF DERMATOLOGICAL SCIENCE (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Toll-like receptor activation in basophils contributes to the development of IgG4-related disease

Tomohiro Watanabe et al.

JOURNAL OF GASTROENTEROLOGY (2013)

添加到收藏夹

Article Immunology

Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy

O. T. Burton et al.

MUCOSAL IMMUNOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis

Mario Noti et al.

NATURE MEDICINE (2013)

添加到收藏夹

Article Medicine, General & Internal

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

Marcus Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Novel Basophil- or Eosinophil-Depleted Mouse Models for Functional Analyses of Allergic Inflammation

Kunie Matsuoka et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

Atsushi Otsuka et al.

NATURE COMMUNICATIONS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade

Juan Manuel Leyva-Castillo et al.

NATURE COMMUNICATIONS (2013)

添加到收藏夹

Article Hematology

Critical role of P1-Runx1 in mouse basophil development

Kaori Mukai et al.

BLOOD (2012)

添加到收藏夹

Article Allergy

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

Jessica H. Savage et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness

Minoru Sawaguchi et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Article Allergy

Basophil recruitment and activation in inflammatory skin diseases

Y. Ito et al.

ALLERGY (2011)

添加到收藏夹

Article Immunology

Genetic analysis of basophil function in vivo

Brandon M. Sullivan et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths

Caspar Ohnmacht et al.

IMMUNITY (2010)

添加到收藏夹

Article Allergy

Autoimmune Response of IgE Antibodies to Cellular Self-Antigens in Systemic Lupus Erythematosus

Ajax Merces Atta et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2010)

添加到收藏夹

Article Medicine, Research & Experimental

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

Takeshi Wada et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

添加到收藏夹

Article Immunology

Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida Hammad et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Article Immunology

The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling

Hua Tang et al.

NATURE IMMUNOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Basophils and the T helper 2 environment can promote the development of lupus nephritis

Nicolas Charles et al.

NATURE MEDICINE (2010)

添加到收藏夹

Review Allergy

Basophil responsiveness in chronic urticaria

Sarbjit S. Saini

CURRENT ALLERGY AND ASTHMA REPORTS (2009)

添加到收藏夹

Reprint Allergy

Cytokine modulation of atopic dermatitis filaggrin skin expression (Reprinted from J Allergy Clin Immunol vol 120, pg 150-5, 2007)

Michael D. Howell et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells

Tomohiro Yoshimoto et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity

Jacqueline G. Perrigoue et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

Caroline L. Sokol et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

Byung Eui Kim et al.

CLINICAL IMMUNOLOGY (2008)

添加到收藏夹

Article Immunology

Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis

Yusuke Tsujimura et al.

IMMUNITY (2008)

添加到收藏夹

Article Immunology

Basophils enhance immunological memory responses

Andrea Denzel et al.

NATURE IMMUNOLOGY (2008)

添加到收藏夹

Article Hematology

Basophils are essential initiators of a novel type of chronic allergic inflammation

Kazushige Obata et al.

BLOOD (2007)

添加到收藏夹

Article Immunology

Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells

K Mukai et al.

IMMUNITY (2005)

添加到收藏夹

Article Critical Care Medicine

Immunohistochemical detection of human basophils in postmortem cases of fatal asthma

CL Kepley et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.