miRNAs Can Affect Intestinal Epithelial Barrier in Inflammatory Bowel Disease

The most obvious pathological characterization of inflammatory bowel disease (IBD) is intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids (miRNA or microRNA), single-stranded noncoding RNAs of similar to 22 nucleotides, have been considered as the potential therapeutic targets in the pathogenesis of IBD. Many previous studies have focused on the mechanisms that miRNAs use to regulate inflammation, immunity, and microorganisms in IBD. The review highlights in detail the findings of miRNAs in the intestinal epithelial barrier of IBD, and focuses on their gene targets, signaling pathways associated with IBD, and some potential therapies. It will be beneficial for the elucidation of the interaction between miRNAs and the intestinal epithelial barrier in IBD and provide a theoretical reference for preventing and treating IBD in the future.

Automated summary

This review provides a detailed overview of the role of micro-ribonucleic acids (miRNAs) in the intestinal epithelial barrier of inflammatory bowel disease (IBD), including their regulation of inflammation, immunity, and microorganisms. The findings of this review contribute to the understanding of the interaction between miRNAs and the intestinal epithelial barrier in IBD and provide a theoretical reference for future prevention and treatment of IBD.