☆ 4.8 Review

Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond

FRONTIERS IN IMMUNOLOGY (2022)

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Summary: Lung fibrosis is characterized by the accumulation of ECM proteins by apoptosis-resistant fibroblasts. Lung epithelial injury leads to fibroblast recruitment and activation, which are necessary for tissue repair. However, under pathological conditions, a vicious cycle of profibrotic factors and cell-matrix signaling promotes the development of lung fibrosis characterized by increased ECM proteins and changes in matrix properties. Understanding the role of ECM in fibrosis can lead to new therapeutic targets and improved outcomes.

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Human Neuraminidases: Structures and Stereoselective Inhibitors

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Summary: This Perspective provides an overview of human neuraminidases, including their classification, structures, substrates, mechanisms of action, and implications in various pathologies. It also discusses the development of inhibitors and different approaches for inhibiting these enzymes.

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Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

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Summary: This review discusses the role of oxidative stress in the development and progression of IPF, the underlying mechanisms, and the evidence of oxidative stress in human IPF. It also analyzes the mechanism of action, efficacy, and current status of different drugs developed to inhibit oxidative stress as anti-fibrotic therapy in IPF.

FRONTIERS IN PHARMACOLOGY (2022)

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Critical Involvement of CD44 in T Helper Type 2 Cell-Mediated Eosinophilic Airway Inflammation in a Mouse Model of Acute Asthma

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FRONTIERS IN IMMUNOLOGY (2022)

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Sialic Acid as a Suitable Marker of Clinical Disease Activity in Patients with Crohn's Disease

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LABORATORY MEDICINE (2022)

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Editorial Material Virology

Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID-19 patients

Wenju Lu et al.

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MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses

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The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling

Sang W. Hyun et al.

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Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88-and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection

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FRONTIERS IN IMMUNOLOGY (2021)

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Review Respiratory System

The role of mucin 1 in respiratory diseases

Beatriz Ballester et al.

Summary: MUC1 is a transmembrane protein involved in pathological processes in the lung, serving as a decoy barrier for mucosal pathogens. Bioactivated MUC1-CT acts as an anti-inflammatory molecule in lung diseases and interacts with effectors linked to cellular transformation, contributing to disease progression.

EUROPEAN RESPIRATORY REVIEW (2021)

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MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Avelino C. Verceles et al.

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Summary: The study reveals that elastin-derived peptides interact with the elastin receptor complex, leading to desialylation of key membrane glycoproteins through NEU1-mediated mechanisms, thereby affecting monocyte adhesion and migration on endothelial cells. These results highlight a potential regulatory role of EDP and ERC in monocyte recruitment to inflamed vascular sites and suggest new biological functions in elastin remodeling-related disorders.

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TGF-β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)

Zhimin Ye et al.

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Discovery of NEU1 as a candidatedone. renal biomarker for proliferative lupus nephritis chronicity

Zhaomin Mao et al.

Summary: A study using proteomics to identify biomarkers of chronicity in patients with proliferative lupus nephritis found that Neuraminidase 1 (NEU1) was highly expressed in the kidney of patients with proliferative LN and correlated with pathological chronicity index (CI) scores and renal outcomes. Urinary excretion of NEU1 was higher in patients with chronicity compared to those without, and high renal NEU1 expression was identified as an independent risk factor for poor renal prognosis.

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Ke Li et al.

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The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion

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MBIO (2021)

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Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis

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BMC ENDOCRINE DISORDERS (2021)

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Review Immunology

Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

Chiel van Geffen et al.

Summary: The immune system plays a crucial role in interstitial lung diseases, especially in the development and treatment response of pulmonary fibrosis. Understanding immune regulation is essential for the development of new therapeutic approaches for idiopathic pulmonary fibrosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Neuraminidase 1 is a driver of experimental cardiac hypertrophy

Qian-Qian Chen et al.

Summary: This study identifies NEU1 as a critical driver of cardiac hypertrophy and inhibition of NEU1 opens up a new field of treatment for cardiovascular diseases. Furthermore, anti-influenza drugs zanamivir and oseltamivir effectively inhibit mammalian NEU1, suggesting new indications for cardio-protection.

EUROPEAN HEART JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Cellular Senescence in Lung Fibrosis

Fernanda Hernandez-Gonzalez et al.

Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

MUC16 Is Overexpressed in Idiopathic Pulmonary Fibrosis and Induces Fibrotic Responses Mediated by Transforming Growth Factor-β1 Canonical Pathway

Beatriz Ballester et al.

Summary: The study reveals the overexpression of MUC16 in lung tissue of IPF patients and its collaboration with the TGF-beta 1 pathway to induce fibrotic processes. Repression of MUC16 expression can inhibit fibrotic processes, suggesting that targeting MUC16 may be a potential drug target for human IPF.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway

Naoki Inui et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by dysregulated repair response induced by recurrent epithelial cell damage and excessive extracellular matrix accumulation. While there is currently no curative therapy for IPF, medications like pirfenidone and nintedanib have been introduced based on understanding the pathogenesis of the disease. Recent advances in understanding IPF pathogenesis have focused on epithelial-mesenchymal transition, the ubiquitin-proteasome system, and the role of endothelial cells in the disease process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Multiple allelic associations from genes involved in energy metabolism were identified in celiac disease

Sandilya Bhagavatula et al.

Summary: Energy metabolism plays a critical role in disease pathogenesis, as demonstrated in this study which identified susceptibility genes associated with celiac disease (CD). The identified genes are key regulators of cellular energy metabolism and have functional implications in immune mediated diseases. Further research is needed to fully understand the proposed CD pathogenesis model and validate its translational application through in vivo methods.

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Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

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Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

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FRONTIERS IN IMMUNOLOGY (2021)

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Is there any relationship between massive ascites and elevated CA-125 in systemic lupus erythematosus? Case report and review of the literature

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Summary: Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease with variable presentation, and massive ascites is infrequent in this context. However, ascites may be the initial manifestation of SLE, and diagnosing it can be challenging due to the various possible causes. Pseudo-Pseudo Meigs Syndrome (PPMS) is a rare entity in SLE patients with ascites, pleural effusion, and CA-125 elevation not related to malignancy.

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MUC1-C influences cell survival in lung adenocarcinoma Calu-3 cells after SARS-CoV-2 infection

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BMB REPORTS (2021)

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Review Rheumatology

The role of lung ultrasound B-lines and serum KL-6 in the screening and follow-up of rheumatoid arthritis patients for an identification of interstitial lung disease: review of the literature, proposal for a preliminary algorithm, and clinical application to cases

Yukai Wang et al.

Summary: Screening and follow-up of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) is challenging in clinical practice due to majority of patients being asymptomatic and lack of optimal tools for early screening. Usual interstitial pneumonia (UIP) is the most frequent radiological and pathological pattern in RA-ILD, indicating poor prognosis and high risk of acute exacerbations and infections. Lung ultrasound (LUS) and serum Krebs von den Lungen-6 antigen (KL-6) have been recognized as sensitive biomarkers for early detection of ILD, showing significant correlation with high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) in systemic sclerosis-associated ILD (SSc-ILD).

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Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis

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Summary: Selective inhibition of NEU1 has been identified as a potential therapeutic intervention for pulmonary fibrotic diseases, showing effectiveness in reducing body weight loss, accumulation of pulmonary lymphocytes, and collagen deposition without observable toxic effects in experimental models.

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Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice

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Summary: NEU3 plays a role in fibrosis by desialylating LAP and releasing TGF-β1. Compounds resembling picolinic acid show potential as NEU3 inhibitors for fibrosis treatment. These NEU3 inhibitors are effective in reducing lung inflammation and fibrosis in a mouse model.

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Summary: Luteolin, a natural flavonoid, shows potential therapeutic effects on gastric cancer by reducing the expression levels of key factors like MUC1, sT antigen, and ADAM-17. It also induces the expression of inflammatory markers like IL-8 and cytokines such as IL-10 and NF-kappa B. The combination of luteolin and Helicobacter pylori seems to have a synergistic effect on suppressing gastric cancer progression.

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MUC1 intracellular bioactivation mediates lung fibrosis

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Systemic sclerosis-associated interstitial lung disease

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Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll-like Receptor 4

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New role for ceramide in hypoxia and insulin resistance

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WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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Oncotarget (2020)

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The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion

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SCIENTIFIC REPORTS (2020)

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Diagnostic and prognostic predictive values of circulating KL-6 for interstitial lung disease A PRISMA-compliant systematic review and meta-analysis

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MEDICINE (2020)

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Krebs von den Lungen-6 as a biomarker for disease severity assessment in interstitial lung disease: a comprehensive review

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BIOMARKERS IN MEDICINE (2020)

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Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response toHelicobacter pyloriInfection in Mice

Yong H. Sheng et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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MUC1-C drives stemness in progression of colitis to colorectal cancer

Wei Li et al.

JCI INSIGHT (2020)

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The role of Neu1 in the protective effect of dipsacoside B on acetaminophen-induced liver injury

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ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis

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LABORATORY INVESTIGATION (2020)

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Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages

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BASIC RESEARCH IN CARDIOLOGY (2020)

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Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation

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BIOCHEMICAL JOURNAL (2020)

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Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease

Lluisa Miro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Contributions of alveolar epithelial cell quality control to pulmonary fibrosis

Jeremy Katzen et al.

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Physical Activity Shapes the Intestinal Microbiome and Immunity of Healthy Mice but Has No Protective Effects against Colitis in MUC2-/- Mice

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MSYSTEMS (2020)

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The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

Yang Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Oxidative Stress in Pulmonary Fibrosis

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COMPREHENSIVE PHYSIOLOGY (2020)

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α-2,3-Sialyltransferase 1 and neuraminidase-3 from monocytes in patients with rheumatoid arthritis correlate with disease activity measures: A pilot study

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Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)

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SCIENTIFIC REPORTS (2019)

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MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes

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PLOS PATHOGENS (2019)

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Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer

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Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage

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MATRIX BIOLOGY (2019)

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New trajectories in the treatment of interstitial lung disease: treat the disease or treat the underlying pattern?

Julie Morisset et al.

CURRENT OPINION IN PULMONARY MEDICINE (2019)

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Neuraminidase 1 regulates proliferation, apoptosis and the expression of Cadherins in mammary carcinoma cells

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MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

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Modulation of TLR4 Sialylation Mediated by a Sialidase Neu1 and Impairment of Its Signaling in Leishmania donovani Infected Macrophages

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FRONTIERS IN IMMUNOLOGY (2019)

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Effect of NOP2 knockdown on colon cancer cell proliferation, migration, and invasion

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TRANSLATIONAL CANCER RESEARCH (2019)

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Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion

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Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex

Charlotte Kawecki et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Sialidase activity in human pathologies

Victor Yu. Glanz et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection

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JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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The Aging Lung and Idiopathic Pulmonary Fibrosis

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Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing

Jose M. Lorenzo-Salazar et al.

ERJ OPEN RESEARCH (2019)

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Pseudo-pseudo Meigs' syndrome: a rare presentation of systemic lupus erythematosus

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REUMATISMO (2019)

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Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells

Osamu Kaminuma et al.

GENES TO CELLS (2018)

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Review Physiology

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

David W. Waters et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Biased G protein-coupled receptor agonism mediates Neu1 sialidase and matrix metalloproteinase-9 crosstalk to induce transactivation of insulin receptor signaling

Fiona Haxho et al.

CELLULAR SIGNALLING (2018)

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Mucins, Mucus, and Goblet Cells

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CHEST (2018)

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Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis

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Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis

Marianna Parlato et al.

EMBO MOLECULAR MEDICINE (2018)

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Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

Justin C. Hewlett et al.

MATRIX BIOLOGY (2018)

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Idiopathic Pulmonary Fibrosis

David J. Lederer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis

Tetsuya Takagawa et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Pharmacology & Pharmacy

A positive feedback loop between IL-1 beta, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages

Irina Sieve et al.

VASCULAR PHARMACOLOGY (2018)

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Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells

Shalini Nath et al.

CELL DEATH & DISEASE (2018)

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Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

Anne Fougerat et al.

MOLECULAR METABOLISM (2018)

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Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

Elizabeth J. White et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Microbiology

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Won Ho Yang et al.

CELL HOST & MICROBE (2018)

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MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

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NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Rhinovirus infections change DNA methylation and mRNA expression in children with asthma

Martin Pech et al.

PLOS ONE (2018)

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Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

Laura A. Hancock et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells

Babita Agrawal et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Respiratory System

Idiopathic Pulmonary Fibrosis Is a Genetic Disease Involving Mucus and the Peripheral Airways

David A. Schwartz

ANNALS OF THE AMERICAN THORACIC SOCIETY (2018)

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Article Biochemistry & Molecular Biology

Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5

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GLYCOBIOLOGY (2018)

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Review Medicine, General & Internal

The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis

Omkar Desai et al.

FRONTIERS IN MEDICINE (2018)

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Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells

Kamala Sundararaj et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Review Medicine, General & Internal

Sialidosis: A Review of Morphology and Molecular Biology of a Rare Pediatric Disorder

Aiza Khan et al.

DIAGNOSTICS (2018)

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Review Medicine, General & Internal

Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics

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FRONTIERS IN MEDICINE (2018)

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Article Biochemistry & Molecular Biology

NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1 through NF-κB pathway in 3T3-L1 adipocytes

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JOURNAL OF BIOCHEMISTRY (2017)

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Article Immunology

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

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JOURNAL OF IMMUNOLOGY (2017)

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Review Hematology

Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

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The cell surface mucin MUC1 limits the severity of influenza A virus infection

J. L. McAuley et al.

MUCOSAL IMMUNOLOGY (2017)

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Recurrent infection progressively disables host protection against intestinal inflammation

Won Ho Yang et al.

SCIENCE (2017)

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Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited

Chiguang Feng et al.

MBIO (2017)

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Article Microbiology

Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1

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MBIO (2017)

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Sialylation regulates myofibroblast differentiation of human skin fibroblasts

Norihiko Sasaki et al.

STEM CELL RESEARCH & THERAPY (2017)

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Mucin 1 protects against severe Streptococcus pneumoniae infection

Poshmaal Dhar et al.

VIRULENCE (2017)

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An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

Toby M. Maher et al.

LANCET RESPIRATORY MEDICINE (2017)

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Review Endocrinology & Metabolism

New insights into the Mechanism of Action of Soluble Klotho

George D. Dalton et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

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Review Medicine, General & Internal

MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function

Kosuke Kato et al.

JOURNAL OF CLINICAL MEDICINE (2017)

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A universal mammalian vaccine cell line substrate

Jackelyn Murray et al.

PLOS ONE (2017)

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Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model

Tejas R. Karhadkar et al.

SCIENTIFIC REPORTS (2017)

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Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis

Kosuke Kato et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Gastroenterology & Hepatology

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

Garrett Z. Ng et al.

GUT (2016)

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Article Cell Biology

Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation

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INFLAMMATION RESEARCH (2016)

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Alveolar epithelial disintegrity in pulmonary fibrosis

Tejaswini Kulkarni et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

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Article Physiology

Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis

Irina G. Luzina et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

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Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

David N. O'Dwyer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Immune Mechanisms in Pulmonary Fibrosis

Saeed Kolahian et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

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Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis

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DISEASE MARKERS (2016)

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Article Genetics & Heredity

The MUC1 mucin specifically inhibits activation of the NLRP3 inflammasome

G. Z. Ng et al.

GENES AND IMMUNITY (2016)

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The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo

Sang W. Hyun et al.

GLYCOBIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-β1 Production

Yin Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Genetics & Heredity

MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis

Francesco Bonella et al.

ORPHANET JOURNAL OF RARE DISEASES (2016)

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Review Physiology

IDIOPATHIC PULMONARY FIBROSIS: A GENETIC DISEASE THAT INVOLVES MUCOCILIARY DYSFUNCTION OF THE PERIPHERAL AIRWAYS

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PHYSIOLOGICAL REVIEWS (2016)

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Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

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BIOMATERIALS SCIENCE (2016)

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Review Pharmacology & Pharmacy

The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential

Amandine Scandolera et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Article Immunology

Association Atudy for 26 Candidate loci in Idiopathic Pulmenary Fibrosis Patients from Four European Populations

Amit Kishore et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study

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PLOS ONE (2016)

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New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability

Pascal Maurice et al.

Scientific Reports (2016)

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Review Respiratory System

Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

Annie Pardo et al.

RESPIRATORY RESEARCH (2016)

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NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

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CELLULAR SIGNALLING (2015)

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Review Biochemistry & Molecular Biology

The cytokines of pulmonary fibrosis: Much learned, much more to learn

Irina G. Luzina et al.

CYTOKINE (2015)

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NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels

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GLYCOBIOLOGY (2015)

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Helicobacter pylori-specific Protection Against Inflammatory Bowel Disease Requires the NLRP3 Inflammasome and IL-18

Daniela B. Engler et al.

INFLAMMATORY BOWEL DISEASES (2015)

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Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release

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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain

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JOURNAL OF IMMUNOLOGY (2015)

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Article Cell Biology

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis

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MEDIATORS OF INFLAMMATION (2015)

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Screening and functional pathway analysis of genes associated with pediatric allergic asthma using a DNA microarray

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MOLECULAR MEDICINE REPORTS (2015)

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Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

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WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

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NATURE COMMUNICATIONS (2015)

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Human milk blocks DC-SIGN-pathogen interaction via MUC1

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FRONTIERS IN IMMUNOLOGY (2015)

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Renal Glycosphingolipid Metabolism Is Dysfunctional in Lupus Nephritis

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Review Respiratory System

Coagulation and anticoagulation in idiopathic pulmonary fibrosis

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EUROPEAN RESPIRATORY REVIEW (2015)

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Distinct Differences in Gene Expression Patterns in Pulmonary Arteries of Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis with Pulmonary Hypertension

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Biochemistry & Molecular Biology

Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Cardiac & Cardiovascular Systems

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway

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CARDIOVASCULAR RESEARCH (2014)

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Review Biochemistry & Molecular Biology

Lysosomal multienzyme complex: pros and cons of working together

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CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

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A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes

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CELLULAR SIGNALLING (2014)

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NEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia

Chunsik Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Pediatrics

Purified Human Breast Milk MUC1 and MUC4 Inhibit Human Immunodeficiency Virus

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NEONATOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis

Shinichiro Ohshimo et al.

RESPIRATORY MEDICINE (2014)

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Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains

Christina E. Faller et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)

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Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

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NATURE COMMUNICATIONS (2014)

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Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

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ELIFE (2014)

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A novel lung injury animal model using KL-6-measurable human MUC1-expressing mice

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Review Biochemistry & Molecular Biology

Desialylation of surface receptors as a new dimension in cell signaling

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BIOCHEMISTRY-MOSCOW (2013)

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Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice

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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

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A novel epidermal growth factor receptor-signaling targeted translation in pancreatic cancer

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DIABETES (2013)

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Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice

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Bleomycin-induced pulmonary fibrosis is attenuated by an antibody against KL-6

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Selected Reaction Monitoring to Differentiate and Relatively Quantitate Isomers of Sulfated and Unsulfated Core 1 O-Glycans from Salivary MUC7 Protein in Rheumatoid Arthritis

Sarah A. Flowers et al.

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MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

Y. H. Sheng et al.

MUCOSAL IMMUNOLOGY (2013)

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Possible association of Neu2 with plasma membrane fraction from mouse thymus exhibited sialidase activity with fetuin at pH 7.0 but not at pH 4.5

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PLOS ONE (2013)

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CURRENT OPINION IN PULMONARY MEDICINE (2012)

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Nobuhisa Ishikawa et al.

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CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice

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GLYCOBIOLOGY (2011)

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Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Is Essential for Toll-like Receptor Activation and Cellular Signaling

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Regulation of Sialyl Lewis Antigen Expression in Colon Cancer Cells by Sialidase NEU4

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Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

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Vaccine against MUC1 Antigen Expressed in Inflammatory Bowel Disease and Cancer Lessens Colonic Inflammation and Prevents Progression to Colitis-Associated Colon Cancer

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CELLULAR SIGNALLING (2010)

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Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

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CELLULAR SIGNALLING (2010)

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A crucial role of sialidase Neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model

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Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin

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Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells

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Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Gαi proteins and matrix metalloproteinase-9

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Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo

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Regulation of Phagocytosis in Macrophages by Neuraminidase 1

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Muc1 Cell Surface Mucin Attenuates Epithelial Inflammation in Response to a Common Mucosal Pathogen

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Deletion of the Mucin-Like Molecule Muc1 Enhances Dendritic Cell Activation in Response to Toll-Like Receptor Ligands

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LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity

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Aberrant Expression of MUC1 Mucin in Pediatric Inflammatory Bowel Disease

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

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Role of alkaline phosphatase in colitis in man and rats

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GUT (2009)

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Protein expression in salivary glands of rats with streptozotocin diabetes

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INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2009)

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

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MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

Eirikur Saeland et al.

MOLECULAR IMMUNOLOGY (2009)

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Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4

T. Uemura et al.

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MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

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Michael J. Hickey et al.

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Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2

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MUC1 mucin is a negative regulator of Toll-like receptor signaling

Keiko Ueno et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

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K. Chul Kim et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

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Over-expression of mammalian sialidase NEU3 reduces Newcastle disease virus entry and propagation in COS7 cells

Luigi Anastasia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2008)

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Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase (NEU1)

Sadagopan Magesh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

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Neuraminiclase 1 is a negative regulator of lysosomal exocytosis

Gouri Yogalingam et al.

DEVELOPMENTAL CELL (2008)

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Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells Neu-medullocyte in the murine thymus

S. Kijimoto-Ochiai et al.

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Review Multidisciplinary Sciences

Aberrant expression of sialidase and cancer progression

Taeko Miyagi

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2008)

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Ajit Varki

TRENDS IN MOLECULAR MEDICINE (2008)

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Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells

Natalia R. Costa et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

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PLOS MEDICINE (2008)

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Release of membrane-associated mucins from ocular surface epithelia

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Roles of T lymphocytes in pulmonary fibrosis

Irina G. Luzina et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

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Expression of mucin 3 and mucin 5AC in arthritic synovial tissue

Michael V. Volin et al.

ARTHRITIS AND RHEUMATISM (2008)

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Inhibition of human immunodeficiency virus type 1 activity by purified human breast milk mucin (MUC1) in an inhibition assay

Habtom H. Habte et al.

NEONATOLOGY (2008)

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Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia

Yuji Ohtsuki et al.

MEDICAL MOLECULAR MORPHOLOGY (2007)

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Article Gastroenterology & Hepatology

Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis

Michael A. Mcguckin et al.

GASTROENTEROLOGY (2007)

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Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis

Yutaro Azuma et al.

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Julie L. McAuley et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Cutting edge:: Transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer

Pamela L. Beatty et al.

JOURNAL OF IMMUNOLOGY (2007)

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Review Medicine, General & Internal

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Daniel C. Baumgart et al.

LANCET (2007)

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Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice

Shinsuke Yoshizumi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2007)

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Search for novel cell surface markers of apoptotic cells

Rostyslav Bilyy et al.

AUTOIMMUNITY (2007)

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Sialidase expression in activated human T lymphocytes influences production of IFN-gamma

Xinli Nan et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

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Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase

Alicja Woronowicz et al.

GLYCOBIOLOGY (2007)

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Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease

Christoph Moehle et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2006)

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Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments

Feng Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Gastroenterology & Hepatology

Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection

Maria Van der Sluis et al.

GASTROENTEROLOGY (2006)

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Article Immunology

Cutting edge:: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice

Wenju Lu et al.

JOURNAL OF IMMUNOLOGY (2006)

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The mucin-1 568 adenosine to guanine polymorphism influences serum Krebs von den Lungen-6 levels

R Janssen et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)

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Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly

A Hinek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Review Physiology

Respiratory tract mucin genes and mucin glycoproteins in health and disease

MC Rose et al.

PHYSIOLOGICAL REVIEWS (2006)

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Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

B Macao et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

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KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts

S Ohshimo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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The MUC1 SEA module is a self-cleaving domain

F Levitin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Evidence for mitochondrial localization of a novel human sialidase (NEU4)

K Yamaguchi et al.

BIOCHEMICAL JOURNAL (2005)

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Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages

NM Stamatos et al.

FEBS JOURNAL (2005)

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Toll-like receptors in innate immunity

K Takeda et al.

INTERNATIONAL IMMUNOLOGY (2005)

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Properties of recombinant human cytosolic sialidase HsNEU2 - The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules

C Tringali et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney

T Higuchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells

V Seyrantepe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

MT1-MMP mediates MUM shedding independent of TACE/ADAM17

A Thathiah et al.

BIOCHEMICAL JOURNAL (2004)

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Article Virology

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

JR Stonebraker et al.

JOURNAL OF VIROLOGY (2004)

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Article Biochemistry & Molecular Biology

Effects of pH on Helicobacter pylori binding to human gastric mucins:: Identification of binding to non-MUC5AC mucins

S Lindén et al.

BIOCHEMICAL JOURNAL (2004)

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Article Biochemistry & Molecular Biology

Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium

S Sakarya et al.

GLYCOBIOLOGY (2004)

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Article Physiology

Pseudomonas aeruginosa stimulates phosphorylation of the airway epithelial membrane glycoprotein Muc1 and activates MAP kinase

EP Lillehoj et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)

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Article Biochemistry & Molecular Biology

Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice

A Sasaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Recruitment of murine neutrophils in vivo through endogenous sialidase activity

AS Cross et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Tumor necrosis factor-α converting enzyme/ADAM 17 mediates MUC1 shedding

A Thathiah et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus

S Kijimoto-Ochiai et al.

GLYCOCONJUGATE JOURNAL (2003)

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Article Immunology

Form and pattern of MUC1 expression on T cells activated in vivo or in vitro suggests a function in T-cell migration

I Correa et al.

IMMUNOLOGY (2003)

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Review Chemistry, Medicinal

Airway mucus: Its components and function

EP Lillehoj et al.

ARCHIVES OF PHARMACAL RESEARCH (2002)

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Article Gastroenterology & Hepatology

Strain- and blood group-dependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms

S Lindén et al.

GASTROENTEROLOGY (2002)

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Article Biochemistry & Molecular Biology

Recent development in mammalian sialidase molecular biology

E Monti et al.

NEUROCHEMICAL RESEARCH (2002)

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Article Biochemistry & Molecular Biology

Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice

N de Geest et al.

HUMAN MOLECULAR GENETICS (2002)

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Article Biochemistry & Molecular Biology

Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells

J Julian et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

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Article Oncology

Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type I Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach

A Teixeira et al.

JOURNAL OF PATHOLOGY (2002)

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Article Critical Care Medicine

Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases

H Ohnishi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

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Article Biochemistry & Molecular Biology

Intracellular distribution of lysosomal sialidase is controlled by the internalization signal in its cytoplasmic tail

KE Lukong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Gastroenterology & Hepatology

Mucin gene expression in intestinal epithelial cells in Crohn's disease

MP Buisine et al.

GUT (2001)

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Article Biochemistry & Molecular Biology

The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and β-catenin

YQ Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation ill the mouse mammary gland

JA Schroeder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Genetics & Heredity

Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease

K Kyo et al.

JOURNAL OF HUMAN GENETICS (2001)

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Article Physiology

Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa

EP Lillehoj et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

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Article Biochemistry & Molecular Biology

Ganglioside control over IL-4 priming and cytokine production in activated T cells

XP Chen et al.

CYTOKINE (2000)

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