4.8 Review

Role of Cytokines in Thymic Regulatory T Cell Generation: Overview and Updates

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

Ryoji Kawakami et al.

Summary: The transcription factor Foxp3 plays crucial roles in Treg cell development and function by controlling Foxp3 transcription. Deletion of CNS0 and CNS3 completely abrogates Treg cell generation and impairs Foxp3 expression stability in residual Treg cells, leading to lethal systemic autoimmunity and inflammation. Hierarchical and coordinated activation of Foxp3 CNS0 and CNS3 initiates and stabilizes Foxp3 gene expression, crucially controlling Treg cell development and self-tolerance.

IMMUNITY (2021)

Article Immunology

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

Stanislav Dikiy et al.

Summary: The CNS0 enhancer ensures robust Treg cell differentiation early in postnatal life and cooperatively minimizes autoimmunity with other tolerance mechanisms.

IMMUNITY (2021)

Article Immunology

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

Saskia Hemmers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Immunology

Regulatory T Cell Development in the Thymus

David L. Owen et al.

JOURNAL OF IMMUNOLOGY (2019)

Article Immunology

Thymic regulatory T cells arise via two distinct developmental programs

David L. Owen et al.

NATURE IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Laurent Chorro et al.

NATURE COMMUNICATIONS (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Review Immunology

TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology

Francoise Meylan et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Article Biochemistry & Molecular Biology

D-mannose induces regulatory T cells and suppresses immunopathology

Dunfang Zhang et al.

NATURE MEDICINE (2017)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Immunology

Immunoregulation by members of the TGFβ superfamily

WanJun Chen et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Immunology

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells

Hiroko Nakatsukasa et al.

NATURE IMMUNOLOGY (2015)

Review Immunology

TGF-beta Activation and Function in Immunity

Mark A. Travis et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Editorial Material Cell Biology

Basis of Treg development in the thymus

Xuguang Tai et al.

CELL CYCLE (2014)

Review Immunology

tTregs, pTregs, and iTregs: similarities and differences

Ethan M. Shevach et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Multidisciplinary Sciences

Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

Guangwei Cui et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

Joanne E. Konkel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Immunology

Development and Maintenance of Regulatory T cells

Naganari Ohkura et al.

IMMUNITY (2013)

Article Immunology

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development

Jennifer E. Cowan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Multidisciplinary Sciences

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Anna Cebula et al.

NATURE (2013)

Review Immunology

Selection of Self-Reactive T Cells in the Thymus

Gretta L. Stritesky et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

Article Multidisciplinary Sciences

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Steven Z. Josefowicz et al.

NATURE (2012)

Review Immunology

Selection of regulatory T cells in the thymus

Chyi-Song Hsieh et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Latent TGF-β structure and activation

Minlong Shi et al.

NATURE (2011)

Article Medicine, Research & Experimental

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

Yenkel Grinberg-Bleyer et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance

Daniel A. Kahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

June L. Round et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Medicine, Research & Experimental

Tregs control the development of symptomatic West Nile virus infection in humans and mice

Marion C. Lanteri et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Immunology

The role of TNF superfamily members in T-cell function and diseases

Michael Croft

NATURE REVIEWS IMMUNOLOGY (2009)

Article Immunology

A two-step process for thymic regulatory T cell development

Chan-Wang Joaquim Lio et al.

IMMUNITY (2008)

Article Immunology

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

Allison L. Bayer et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Immunology

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Yukiko Tone et al.

NATURE IMMUNOLOGY (2008)

Article Immunology

IL-2Rβ links IL-2R signaling with foxp3 expression

David M. Soper et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Review Medicine, Research & Experimental

Tregs and rethinking cancer immunotherapy

Tyler J. Curiel

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

FOXP3 controls regulatory T cell function through cooperation with NFAT

Yongqing Wu et al.

Article Immunology

A function for interleukin 2 in Foxp3-expressing regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2005)

Article Immunology

Developmental regulation of Foxp3 expression during ontogeny

JD Fontenot et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Immunology

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

JC Marie et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Immunology

Regulatory T cells mediate maternal tolerance to the fetus

VR Aluvihare et al.

NATURE IMMUNOLOGY (2004)

Article Immunology

An essential role for Scurfin in CD4+CD25+ T regulatory cells

R Khattri et al.

NATURE IMMUNOLOGY (2003)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2003)

Article Multidisciplinary Sciences

Control of regulatory T cell development by the transcription factor Foxp3

S Hori et al.

SCIENCE (2003)

Article Immunology

Interleukin 2 signaling is required for CD4+ regulatory T cell function

GC Furtado et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

Article Immunology

Origin of regulatory T cells with known specificity for antigen

I Apostolou et al.

NATURE IMMUNOLOGY (2002)

Article Immunology

Requirement for transforming growth factor β1 in controlling T cell apoptosis

WJ Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)