期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.799306
关键词
P; falciparum malaria; recombinant antigens; memory B-cells; antibodies; FluoroSpot
类别
资金
- Swedish Foundation for Strategic Research [ID14-0070]
- Swedish Research Council [2018-04468]
- Karolinska Institutet Travel Grant [2018-02525]
- MRC/UKRI African Research Leadership Award [MR/P020321/1]
- Senior Fellowship from EDCTP [TMA2016SF]
- Swedish Foundation for Strategic Research (SSF) [ID14-0070] Funding Source: Swedish Foundation for Strategic Research (SSF)
- Swedish Research Council [2018-04468] Funding Source: Swedish Research Council
Researchers found that children with a breadth of three or more antigen-specific memory B-cell (MBC) or antibody responses had a reduced risk for malaria in the subsequent Plasmodium falciparum transmission season.
Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-existing memory B-cells (MBCs) and antibody responses against six well known P. falciparum antigens (MSP-1(19), MSP-2 (3D7), MSP-2 (FC27), MSP-3, AMA-1 and CSP) and measured their associations with previous infections and time to clinical malaria in the ensuing malaria season in Kenyan children. These children were under active weekly surveillance for malaria as part of a long-term longitudinal malaria immunology cohort study, where they are recruited from birth. After performing Cox regression analysis, we found that children with a breadth of three or more antigen-specific MBC or antibody responses at the baseline had a reduced risk for malaria in the ensuing P. falciparum transmission season. Specifically, MBC responses against AMA-1, MSP-2 (3D7) and MSP-3, as well as antibody responses to MSP-2 (3D7) and MSP-3 were prospectively associated with a reduced risk for malaria. The magnitude or breadth of MBC responses were however not correlated with the cumulative number of malaria episodes since birth. We conclude that increased breadth for merozoite antigen-specific MBC and antibody responses is associated with protection against malaria.
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