期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.845969
关键词
SARS-CoV-2; COVID-19; MVA vaccine; spike; hamsters; immunogenicity; efficacy
类别
资金
- Fondo COVID-19 grant [COV20/00151]
- [Instituto de Salud Carlos III (ISCIII)], Fondo Supera COVID-19 grant
- Spanish Research Council (CSIC) [202120E079]
- CSIC [2020E84, CF01-00008]
- MAPFRE donations
- Spanish Ministry of Science and Innovation (MCIN)/Spanish Research Agency (AEI) [PID2020-114481RB-I00]
- KU Leuven - European Commission-NextGeneration EU
This study reports the potent immunogenicity and efficacy of a vaccine candidate based on a modified vaccinia virus Ankara (MVA) vector in hamsters. The vaccine induced high levels of neutralizing antibodies against SARS-CoV-2 and its variants, and resulted in reduced viral RNA and infectious virus in the lungs of vaccinated hamsters. These findings support the potential use of MVA-S as a vaccine candidate for SARS-CoV-2.
To control the coronavirus disease 2019 (COVID-19) pandemic and the emergence of different variants of concern (VoCs), novel vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed. In this study, we report the potent immunogenicity and efficacy induced in hamsters by a vaccine candidate based on a modified vaccinia virus Ankara (MVA) vector expressing a human codon optimized full-length SARS-CoV-2 spike (S) protein (MVA-S). Immunization with one or two doses of MVA-S elicited high titers of S- and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against parental SARS-CoV-2 and VoC alpha, beta, gamma, delta, and omicron. After SARS-CoV-2 challenge, MVA-S-vaccinated hamsters showed a significantly strong reduction of viral RNA and infectious virus in the lungs compared to the MVA-WT control group. Moreover, a marked reduction in lung histopathology was also observed in MVA-S-vaccinated hamsters. These results favor the use of MVA-S as a potential vaccine candidate for SARS-CoV-2 in clinical trials.
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