期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.877634
关键词
ferroptosis; immune cell; iron metabolism; tumors; GPX4
类别
资金
- Foundation of Key Discipline Construction of Zhejiang Province for Traditional Chinese Medicine [2017-XK-A36]
- Opening Foundation of State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases [2018KF02]
The aim of this review is to explore the relationship between ferroptosis and immune cells, as well as the role of ferroptosis in infection, inflammation, and tumors, in order to identify potential therapeutic targets.
Ferroptosis is a form of programmed cell death that was only recognized in 2012. Until recently, numerous researchers have turned their attention to the mechanism and function of ferroptosis. A large number of studies have shown potential links between cell ferroptosis and infection, inflammation, and tumor. At the same time, immune cells are vital players in these above-mentioned processes. To date, there is no comprehensive literature review to summarize the relationship between ferroptosis and immune cells. Therefore, it is of great significance to explore the functional relationship between the two. This review will attempt to explain the link between ferroptosis and various immune cells, as well as determine the role ferroptosis plays in infection, inflammation, and malignancies. From this, we may find the potential therapeutic targets of these diseases.
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