期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.862053
关键词
viral infection; dendritic cell; blood-brain barrier; neuroinflammation; neuroinfections; blood-cerebrospinal barrier
类别
资金
- ANR (the French National Research Agency) under the Investissements d'avenir program [ANR-16-IDEX-0006]
- la Region Occitanie through the PhD funding program [R19068FF]
This review highlights the important contribution of dendritic cells in the development and consequences of viral brain infections.
To gain access to the brain, a so-called immune-privileged organ due to its physical separation from the blood stream, pathogens and particularly viruses have been selected throughout evolution for their use of specific mechanisms. They can enter the central nervous system through direct infection of nerves or cerebral barriers or through cell-mediated transport. Indeed, peripheral lymphoid and myeloid immune cells can interact with the blood-brain and the blood-cerebrospinal fluid barriers and allow viral brain access using the Trojan horse mechanism. Among immune cells, at the frontier between innate and adaptive immune responses, dendritic cells (DCs) can be pathogen carriers, regulate or exacerbate antiviral responses and neuroinflammation, and therefore be involved in viral transmission and spread. In this review, we highlight an important contribution of DCs in the development and the consequences of viral brain infections.
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