4.8 Article

GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Comparative Toxicogenomics Database (CTD): update 2021

Allan Peter Davis et al.

Summary: The public Comparative Toxicogenomics Database (CTD) is a digital ecosystem that integrates toxicological information to advance understanding about human health. With a 20% increase in curated content, CTD now provides an extensive dataset for over 16,300 chemicals, 51,300 genes, and more, enhancing its usefulness as a resource for generating testable hypotheses about environmentally influenced diseases.

NUCLEIC ACIDS RESEARCH (2021)

Review Nursing

Patient's experiences of suffering across the cancer trajectory: A qualitative systematic review protocol

Ayuk Cucuk Iskandar et al.

Summary: This study aims to systematically identify and explore the suffering experienced by cancer patients during their illness trajectories, providing support and recommendations for nursing development.

JOURNAL OF ADVANCED NURSING (2021)

Review Pharmacology & Pharmacy

Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3

Nan Li et al.

Summary: Cancer immunotherapies have revolutionized the treatment of adult malignancies and are now being translated to pediatric oncology. Successful immunotherapeutic agents for pediatric cancers include chimeric antigen receptor T-cell therapy, bispecific antibodies targeting CD19, and anti-GD2 monoclonal antibody. Advancements in tumor immunology and genome profiling have led to the identification of new tumor-specific antigens, such as Glypican 2 (GPC2) and B7-H3 (CD276), which could have a positive impact on pediatric cancer treatment.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Oncology

Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization

Samantha Buongervino et al.

Summary: In this study, it was found that DNA binding drugs exhibit higher cytotoxicity to neuroblastomas compared to tubulin-binding or DNA topoisomerase 1 inhibiting drugs. The internalization kinetics of antibodies in neuroblastomas correlated significantly with GPC2 cell surface density, while sensitivity to PBD dimers primarily determined the efficacy of corresponding ADC, outweighing the influence of GPC2 cell surface density and antibody internalization.

MOLECULAR CANCER THERAPEUTICS (2021)

Meeting Abstract Oncology

TARGETING GLYPICAN 2 (GPC2) ON PEDIATRIC MALIGNANT BRAIN TUMORS WITH MRNA CAR T CELLS

Jessica Foster et al.

NEURO-ONCOLOGY (2021)

Article Cell Biology

A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

Swetha Raman et al.

Summary: GPC2 is a MYCN-regulated oncoprotein that is highly expressed in neuroblastoma and small-cell lung cancers (SCLCs), making it a potential target for immune-based therapies and ADCs. Studies have shown that the GPC2-directed ADC can induce durable tumor regression in neuroblastoma and SCLC by inducing DNA damage, apoptosis, and bystander cell killing, with no signs of in vivo toxicity.

CELL REPORTS MEDICINE (2021)

Article Cell Biology

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Nan Li et al.

Summary: The study utilized RNA sequencing analysis to identify high expression of GPC2 exons 3 and exons 7-10 in cancer but minimal expression in normal tissues. A monoclonal antibody CT3 was discovered and used to design CAR T cells for treating neuroblastoma. Genomic sequencing of T cells recovered from mice revealed potential CAR integration sites contributing to CART cell proliferation and persistence.

CELL REPORTS MEDICINE (2021)

Review Oncology

A review of cancer immunotherapy toxicity

Lucy Boyce Kennedy et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Oncology

CAR T cells: continuation in a revolution of immunotherapy

Anurag K Singh et al.

LANCET ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Glypican 2 regulates cell proliferation and metastasis in thyroid cancer cells

Tao Zhang et al.

MOLECULAR & CELLULAR TOXICOLOGY (2020)

Editorial Material Oncology

Pan-Cancer Early Detection: Hype or Hope?

Sudhir Srivastava et al.

CANCER CELL (2020)

Review Oncology

Promoter DNA Hypermethylation and Paradoxical Gene Activation

Jim Smith et al.

TRENDS IN CANCER (2020)

Review Chemistry, Medicinal

Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment

Fubo Zhou et al.

MEDICINAL RESEARCH REVIEWS (2018)

Editorial Material Biochemistry & Molecular Biology

SnapShot: TCGA-Analyzed Tumors

Amy Blum et al.

Review Oncology

Glypicans as Cancer Therapeutic Targets

Nan Li et al.

TRENDS IN CANCER (2018)

Article Medicine, Research & Experimental

Molecular network-based identification of competing endogenous RNAs and mRNA signatures that predict survival in prostate cancer

Ning Xu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Review Cell Biology

Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

Heikki Rauvala et al.

NEURAL REGENERATION RESEARCH (2017)

Article Multidisciplinary Sciences

Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis

S. Lugert et al.

SCIENTIFIC REPORTS (2017)

Editorial Material Medicine, Research & Experimental

Cancer immunotherapy: harnessing the immune system to battle cancer

Yiping Yang

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Article Rehabilitation

Comparison of Diagnostic Accuracy of Clinical Measures of Breast Cancer-Related Lymphedema: Area Under the Curve

Betty J. Smoot et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2011)

Article Hematology

Natural killer-cell differentiation by myeloid progenitors

Bartosz Grzywacz et al.

Article Biochemistry & Molecular Biology

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Leonardo Salmena et al.

Article Cell & Tissue Engineering

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

Tiago C. Luis et al.

CELL STEM CELL (2011)

Review Biotechnology & Applied Microbiology

Glypicans

Jorge Filmus et al.

GENOME BIOLOGY (2008)

Article Oncology

Identification of glypican-3 as a novel tumor marker for melanoma

T Nakatsura et al.

CLINICAL CANCER RESEARCH (2004)