期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.893204
关键词
RIG-I; activators; signal pathway; inflammation; cardiovascular diseases
类别
资金
- National Natural Science Foundation of China [82070760, 82070701, 81600352,82100779]
- Jiangsu Provincial Maternal and Child Health Research Institute [JSFY202105]
- Nanjing National Commission on Health and Family Planning [ZKX19042, YKK18146]
RIG-I is a cytosolic pattern recognition receptor that plays a role in both antiviral and non-viral infectious diseases. It is widely expressed in the cardiovascular system and has potential research value in the treatment of cardiovascular diseases.
Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain. RIG-I initiates antiviral innate immunity by recognizing exogenous viral RNAs/DNAs. However, some studies have reported that RIG-I activation leads to damage in various organs and tissues in diverse circumstances. Recent studies have shown that RIG-I is involved in cancer, lupus nephritis, immunoglobulin A nephropathy, Crohn's disease, and atherosclerosis. These reports indicate that RIG-I not only participates in antiviral signaling pathways but also exerts an influence on non-viral infectious diseases. RIG-I is widely expressed in immune and non-immune cells including smooth muscle cells, endothelial cells, and cardiomyocytes. A succinct overview of RIG-I and its signaling pathways, with respect to the cardiovascular system, will aid in the development of novel therapeutics for cardiovascular diseases. In this review, we summarize the structure, activation, signaling pathways, and role of RIG-I in cardiovascular diseases.
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