期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.833699
关键词
systemic lupus erythematosus; proteomic; metabolomic; lipidomic; pathogenesis
类别
资金
- Public service development and reform pilot project of Beijing Medical Research Institute [BMR2019-11]
- National natural science foundation of China [81970900]
- Beijing Social Science Foundation Project [19GLB033]
This study investigated the molecular characteristics of systemic lupus erythematosus (SLE) patients with different disease activity levels using a comprehensive multi-omics analysis. The results showed that the complement system and inflammatory response were activated in SLE patients and were associated with disease activity. Additionally, the immunoglobulin mediated immune response was activated in patients with low disease activity but slightly suppressed in patients with high disease activity. Imbalance in lipid metabolism, particularly sphingolipid metabolism, and dysregulated apolipoproteins were also observed to contribute to the disease activity of SLE.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, using an integrated multi-omics approach have not been fully investigated. Here, we collected blood samples from 10 healthy controls (HCs) and 40 SLE patients with different clinical activity including inactive (IA), low activity (LA), and high activity (HA). Using an integrative analysis of proteomic, metabolomic and lipidomic profiles, we report the multi-omics landscape for SLE. The molecular changes suggest that both the complement system and the inflammatory response were activated in SLEs and were associated with disease activity. Additionally, activation of the immunoglobulin mediated immune response were observed in the LA stage of the disease, however this immune response was suppressed slightly in the HA stage. Finally, an imbalance in lipid metabolism, especially in sphingolipid metabolism, accompanied with dysregulated apolipoproteins were observed to contribute to the disease activity of SLE. The multi-omics data presented in this study and the characterization of peripheral blood from SLE patients may thus help provide important clues regarding the pathogenesis of SLE.
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