期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 21, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.21.5.056002
关键词
polarization; microscopes; polarimetry; tissues; Mueller matrix
资金
- National Natural Science Foundation of China [11174178, 11374179, 61205199, 61405102]
- Science and Technology Project of Shenzhen Grant [CXZZ20140509172959978, GJHZ20150316160614844]
A polarization microscope is a useful tool to reveal the optical anisotropic nature of a specimen and can provide abundant microstructural information about samples. We present a division of focal plane (DoFP) polarimeter-based polarization microscope capable of simultaneously measuring both the Stokes vector and the 3 x 4 Mueller matrix with an optimal polarization illumination scheme. The Mueller matrix images of unstained human carcinoma tissue slices show that the m(24) and m(34) elements can provide important information for pathological observations. The characteristic features of the m(24) and m(34) elements can be enhanced by polarization staining under illumination by a circularly polarized light. Hence, combined with a graphics processing unit acceleration algorithm, the DoFP polarization microscope is capable of real-time polarization imaging for potential quick clinical diagnoses of both standard and frozen slices of human carcinoma tissues. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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