期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 21, 期 1, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.21.1.018001
关键词
photodynamic antimicrobial chemotherapy; zinc phthalocyanine; bacterial infection; skin; Propionibacterium acnes; Staphylococcus aureus
资金
- National Natural Science Foundation [81171634]
- Fujian Natural Science Foundation [2013J01387, 2013J01066]
Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine beta-carbonylphthalocyanine zinc (ZnPc-(Lys)(5)). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)(5) showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)(5) was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
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