4.7 Article

Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives

Lu Feng et al.

Summary: BRD4, a chromatin reader protein in the BET family, regulates cellular processes by binding acetylated histones and non-histone proteins. Designing dual-target inhibitors of BET bromodomains is a rational strategy in cancer treatment.

MEDICINAL RESEARCH REVIEWS (2022)

Review Chemistry, Medicinal

Inhibitors of bromodomain and extra-terminal proteins for treating multiple human diseases

Ewelina Kulikowski et al.

Summary: The clinical development of BET protein inhibitors is unique, as they are being widely evaluated for treating various human diseases due to their novel mechanism of action. Among the BET protein family, BRD4 is extensively studied, and its activity at latent enhancers is a representative example of BET protein function. The role of BET proteins in embryonic development, cancer, cardiovascular, autoimmune, and metabolic diseases makes them attractive targets for therapeutic intervention.

MEDICINAL RESEARCH REVIEWS (2021)

Article Multidisciplinary Sciences

BRD4-mediated repression of p53 is a target for combination therapy in AML

Anne-Louise Latif et al.

Summary: The study reveals that MDM2 and BET inhibitors can synergize by stabilizing p53 protein and inhibiting BRD4-mediated suppression of p53 target genes, enhancing the therapeutic efficacy for AML treatment.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation

Yufei Yan et al.

Summary: Hepatic fibrosis is characterized by the accumulation of extracellular matrix in the liver due to persistent injury. Understanding the cellular and molecular mechanisms controlling the fibrotic response is crucial for developing clinical strategies to prevent fibrosis progression. Activation of hepatic stellate cells plays a key role in promoting ECM synthesis, and various external signals contribute to this process.

BIOMEDICINES (2021)

Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Multidisciplinary Sciences

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Mingzhu Yin et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Opposing Functions of BRD4 Isoforms in Breast Cancer

Shwu-Yuan Wu et al.

MOLECULAR CELL (2020)

Review Biochemistry & Molecular Biology

Domain-selective targeting of BET proteins in cancer and immunological diseases

Massimo Petretich et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

Julia Wilflingseder et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

Marco Segatto et al.

NATURE COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

BET bromodomain inhibition suppresses adipogenesis in mice

Qiong Duan et al.

ENDOCRINE (2020)

Article Biochemistry & Molecular Biology

Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling

Bing Tian et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Maurizio Parola et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

Review Biotechnology & Applied Microbiology

Bromodomains: a new target class for drug development

Andrea G. Cochran et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Cardiac & Cardiovascular Systems

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

Matthew S. Stratton et al.

CIRCULATION RESEARCH (2019)

Article Medicine, Research & Experimental

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer

Yuqian Yan et al.

EMBO MOLECULAR MEDICINE (2019)

Review Medicine, Research & Experimental

The balancing act of the liver: tissue regeneration versus fibrosis

Lucia Cordero-Espinoza et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Gastroenterology & Hepatology

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

Nadine Gehrke et al.

JOURNAL OF HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Determinants of fibrosis progression and regression in NASH

Detlef Schuppan et al.

JOURNAL OF HEPATOLOGY (2018)

Review Biochemistry & Molecular Biology

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Detlef Schuppan et al.

MATRIX BIOLOGY (2018)

Review Gastroenterology & Hepatology

Targeting hepatic macrophages to treat liver diseases

Frank Tacke

JOURNAL OF HEPATOLOGY (2017)

Article Multidisciplinary Sciences

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Andrew P. Turnbull et al.

NATURE (2017)

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Immunology

Liver macrophages in tissue homeostasis and disease

Oliver Krenkel et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Microbiology

The Liver at the Nexus of Host-Microbial Interactions

Andrew J. Macpherson et al.

CELL HOST & MICROBE (2016)

Review Immunology

Liver immunology and its role in inflammation and homeostasis

Mark W. Robinson et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2016)

Article Gastroenterology & Hepatology

A synthetic biology-based device prevents liver injury in mice

Peng Bai et al.

JOURNAL OF HEPATOLOGY (2016)

Review Biotechnology & Applied Microbiology

Epigenetic drug discovery: breaking through the immune barrier

David F. Tough et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Biochemistry & Molecular Biology

Matrix metalloproteinases in liver injury, repair and fibrosis

Sergio Duarte et al.

MATRIX BIOLOGY (2015)

Article Multidisciplinary Sciences

BRD4 is a novel therapeutic target for liver fibrosis

Ning Ding et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Gastroenterology & Hepatology

Roles for Chemokines in Liver Disease

Fabio Marra et al.

GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Macrophage heterogeneity in liver injury and fibrosis

Frank Tacke et al.

JOURNAL OF HEPATOLOGY (2014)

Review Biochemistry & Molecular Biology

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

Junwei Shi et al.

MOLECULAR CELL (2014)

Review Immunology

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Medicine, Research & Experimental

Evolving therapies for liver fibrosis

Detlef Schuppan et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

Panagis Filippakopoulos et al.

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Pathology

Pathogenesis of Liver Fibrosis

Virginia Hernandez-Gea et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)

Review Gastroenterology & Hepatology

NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma

Tom Luedde et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Review Immunology

Transcriptional control of the inflammatory response

Ruslan Medzhitov et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Gastroenterology & Hepatology

Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice

I Sakaida et al.

HEPATOLOGY (2004)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Review Cell Biology

Myofibroblasts and mechano-regulation of connective tissue remodelling

JJ Tomasek et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

Review Gastroenterology & Hepatology

Matrix as a modulator of hepatic fibrogenesis

D Schuppan et al.

SEMINARS IN LIVER DISEASE (2001)