相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives
Lu Feng et al.
MEDICINAL RESEARCH REVIEWS (2022)
Inhibitors of bromodomain and extra-terminal proteins for treating multiple human diseases
Ewelina Kulikowski et al.
MEDICINAL RESEARCH REVIEWS (2021)
BRD4-mediated repression of p53 is a target for combination therapy in AML
Anne-Louise Latif et al.
NATURE COMMUNICATIONS (2021)
Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
Yufei Yan et al.
BIOMEDICINES (2021)
Molecular and cellular mechanisms of liver fibrosis and its regression
Tatiana Kisseleva et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Omer Gilan et al.
SCIENCE (2020)
Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors
Zizhou Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
Mingzhu Yin et al.
NATURE COMMUNICATIONS (2020)
Opposing Functions of BRD4 Isoforms in Breast Cancer
Shwu-Yuan Wu et al.
MOLECULAR CELL (2020)
BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma
Chengzhang Shi et al.
NEURO-ONCOLOGY (2020)
Domain-selective targeting of BET proteins in cancer and immunological diseases
Massimo Petretich et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2020)
Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury
Julia Wilflingseder et al.
NATURE COMMUNICATIONS (2020)
Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function
Soo Young Kim et al.
CIRCULATION (2020)
BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
Marco Segatto et al.
NATURE COMMUNICATIONS (2020)
BET bromodomain inhibition suppresses adipogenesis in mice
Qiong Duan et al.
ENDOCRINE (2020)
Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling
Bing Tian et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
Maurizio Parola et al.
MOLECULAR ASPECTS OF MEDICINE (2019)
Bromodomains: a new target class for drug development
Andrea G. Cochran et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation
Matthew S. Stratton et al.
CIRCULATION RESEARCH (2019)
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer
Yuqian Yan et al.
EMBO MOLECULAR MEDICINE (2019)
Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury
Maria Ruart et al.
JOURNAL OF HEPATOLOGY (2019)
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2019)
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
Jinjin Peng et al.
THERANOSTICS (2019)
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms
Maria Kleppe et al.
CANCER CELL (2018)
Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2
Tian Lan et al.
HEPATOLOGY (2018)
The balancing act of the liver: tissue regeneration versus fibrosis
Lucia Cordero-Espinoza et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation
Nadine Gehrke et al.
JOURNAL OF HEPATOLOGY (2018)
Determinants of fibrosis progression and regression in NASH
Detlef Schuppan et al.
JOURNAL OF HEPATOLOGY (2018)
Liver fibrosis: Direct antifibrotic agents and targeted therapies
Detlef Schuppan et al.
MATRIX BIOLOGY (2018)
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells
Yan Jia et al.
REDOX BIOLOGY (2018)
Targeting hepatic macrophages to treat liver diseases
Frank Tacke
JOURNAL OF HEPATOLOGY (2017)
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Andrew P. Turnbull et al.
NATURE (2017)
Mechanisms of hepatic stellate cell activation
Takuma Tsuchida et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)
BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
Qiming Duan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Liver macrophages in tissue homeostasis and disease
Oliver Krenkel et al.
NATURE REVIEWS IMMUNOLOGY (2017)
The Liver at the Nexus of Host-Microbial Interactions
Andrew J. Macpherson et al.
CELL HOST & MICROBE (2016)
Liver immunology and its role in inflammation and homeostasis
Mark W. Robinson et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2016)
A synthetic biology-based device prevents liver injury in mice
Peng Bai et al.
JOURNAL OF HEPATOLOGY (2016)
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
Shaokun Shu et al.
NATURE (2016)
Epigenetic drug discovery: breaking through the immune barrier
David F. Tough et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
Chang Yeob Han et al.
NATURE COMMUNICATIONS (2016)
Matrix metalloproteinases in liver injury, repair and fibrosis
Sergio Duarte et al.
MATRIX BIOLOGY (2015)
BRD4 is a novel therapeutic target for liver fibrosis
Ning Ding et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Yang Liao et al.
BIOINFORMATICS (2014)
Roles for Chemokines in Liver Disease
Fabio Marra et al.
GASTROENTEROLOGY (2014)
Macrophage heterogeneity in liver injury and fibrosis
Frank Tacke et al.
JOURNAL OF HEPATOLOGY (2014)
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Junwei Shi et al.
MOLECULAR CELL (2014)
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
Antonella Pellicoro et al.
NATURE REVIEWS IMMUNOLOGY (2014)
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin et al.
BIOINFORMATICS (2013)
BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
Miguel F. Segura et al.
CANCER RESEARCH (2013)
Evolving therapies for liver fibrosis
Detlef Schuppan et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
Panagis Filippakopoulos et al.
CELL (2012)
Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages
Dowty Movita et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2012)
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Guangchuang Yu et al.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)
Pathogenesis of Liver Fibrosis
Virginia Hernandez-Gea et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Mark A. Dawson et al.
NATURE (2011)
NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma
Tom Luedde et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
Mark D. Robinson et al.
BIOINFORMATICS (2010)
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai et al.
NATURE IMMUNOLOGY (2010)
New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting
Andrew D. Wells
JOURNAL OF IMMUNOLOGY (2009)
Transcriptional control of the inflammatory response
Ruslan Medzhitov et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
MK Jang et al.
MOLECULAR CELL (2005)
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
I Sakaida et al.
HEPATOLOGY (2004)
Cytoscape: A software environment for integrated models of biomolecular interaction networks
P Shannon et al.
GENOME RESEARCH (2003)
Myofibroblasts and mechano-regulation of connective tissue remodelling
JJ Tomasek et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Matrix as a modulator of hepatic fibrogenesis
D Schuppan et al.
SEMINARS IN LIVER DISEASE (2001)