期刊
BIOENGINEERED
卷 13, 期 3, 页码 6024-6035出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2022.2042134
关键词
ovarian cancer; TRIM21; proliferation; migration
资金
- Natural Science Foundation of Jiangsu Province [BK20180989]
- National Postdoctoral Research Funds of China [2019M651971, 2021T140577]
- Scientific Research Project of Jiangsu Province Maternal and child Health Care Association [FYX202023]
TRIM21 expression is decreased in ovarian cancer patients and is associated with shorter survival. It inhibits cancer progression by suppressing cell migration, invasion, and proliferation. Therefore, TRIM21 may serve as a promising biomarker and therapeutic target for ovarian cancer.
Tripartite motif-containing 21 (TRIM21) has been reported to have a cancer-promoting or anticancer effect in various tumors; however, its role in ovarian cancer (OC) remains to be elucidated. In this study, we explored the biological function of TRIM21 in OC progression and investigated the potential mechanisms. We found that TRIM21 was remarkably decreased in OC tissues and cell lines compared with adjacent-cancerous tissues and normal ovarian epithelium cell. Decreased expression of TRIM21 in OC patients was significantly correlated with shorter overall and disease-specific survival by The Cancer Genome Atlas database (TCGA) analysis. Functional assays revealed that TRIM21 inhibited the migration and invasion of OC cells; and that TRIM21 also obviously impaired cell proliferation by inhibiting cell cycle progression in vitro and in vivo. Taken together, our results suggest that TRIM21 may be a promising biomarker and target for OC diagnosis and treatment.
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