Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis

Article Biotechnology & Applied Microbiology

Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis

Fei Xie et al.

Summary: This study reveals that circ_0048764 promotes the development of BC by modulating the miR-1296-5p/TRIM14 axis. It enhances the proliferative, migrative, and invasive abilities of BC cells, and inhibits apoptosis.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis

Weifu He et al.

Summary: This study reveals that circ_0019693 promotes BMSC osteogenic differentiation and osteogenesis-coupled angiogenesis by regulating miR-942-5p-targeted PCP4, thereby blocking the development of osteoporosis.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Lingling Xu et al.

Summary: ADIRF-AS1 is overexpressed in osteosarcoma (OS) and acts as a competitive endogenous RNA, sequestering miR-761 and leading to overexpression of its target gene IRS1. Knockdown of ADIRF-AS1 inhibits proliferation, migration, and invasiveness of OS cells and promotes apoptosis. These findings may contribute to the development of lncRNA-directed therapeutics for OS.

BIOENGINEERED (2022)

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Review Biochemistry & Molecular Biology

Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages

Nuno Lopes et al.

Summary: The immune microenvironment of breast cancer is influenced by tumor-associated macrophages (TAM), which play a critical role in immune suppression and cancer progression. Recent studies have identified altered glycan structures on breast cancer cells as potential targets for novel immunotherapies, highlighting the potential of targeting glycan-lectin interactions to reshape the immunosuppressive landscape of breast cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

circUBAP2 regulates osteosarcoma progression via the miR-204-3p/HMGA2 axis

Weiguo Ma et al.

Summary: The study showed that circular RNA-ubiquitin associated protein 2 is upregulated in osteosarcoma and regulates malignant behavior of osteosarcoma cells through the miR-204-3p/HMGA2 axis.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Oncology

Circ_0000003 regulates glutamine metabolism and tumor progression of tongue squamous cell carcinoma via the miR-330-3p/GLS axis

Cuijuan Qian et al.

Summary: circ_0000003 plays an important role in TSCC by promoting cell proliferation, migration, and invasion. It regulates glutamine metabolism by modulating the miR-330-3p/GLS pathway.

ONCOLOGY REPORTS (2021)

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Article Obstetrics & Gynecology

Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration

Tingting Qi et al.

Summary: The study identified a novel circUBAP2 downregulated in PE patients, which inhibited cell proliferation and migration when knocked down. CircUBAP2 sponged miR-1244 to target FOXM1, suggesting a potential molecular marker for the diagnosis and treatment of PE.

REPRODUCTIVE SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway

Shaoxia Fan et al.

Summary: In this study, it was found that ACTL8 is upregulated in TNBC and is associated with poor prognosis. Silencing ACTL8 inhibited proliferation, migration, and invasion while promoting apoptosis in MDA-MB-231 and BT-549 cells. Additionally, silencing ACTL8 suppressed the activation of the PI3K/AKT/mTOR signaling pathway in these cells, indicating a potential mechanism of ACTL8 in TNBC progression.

ONCOTARGETS AND THERAPY (2021)

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Article Multidisciplinary Sciences

Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity

Johanne Mbianda et al.

Summary: The study demonstrates that the structural plasticity of foldamer backbone is crucial for optimal interaction with protein surface. By designing a foldamer/peptide hybrid inhibitor using oligoureas as α-helix mimics, effective inhibition of the key regulator of chromatin dynamics, histone chaperone ASF1, was achieved. Additionally, the ASF1 ligands with nonpeptide oligourea segments showed significantly improved resistance to proteolysis in human plasma compared to alpha-helical peptides.

SCIENCE ADVANCES (2021)

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Article Oncology

PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway

Huayu Hu et al.

Summary: Research has shown that PIK3CA mutation promotes the growth and migratory ability of tumor cells in TNBC, while also inhibiting the apoptosis process. This mutation leads to chemotherapy resistance in TNBC.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Min Liang et al.

Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells

Hui Xiong et al.

Summary: In thyroid cancer, circUBAP2 is upregulated while miR-370-3p is downregulated. CircUBAP2 acts as a sponge to inhibit miR-370-3p expression, thereby impeding proliferation and invasion while inducing apoptosis in thyroid cancer cells.

HUMAN CELL (2021)

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Article Oncology

Comprehensive analysis of pan-cancer reveals potential of ASF1B as a prognostic and immunological biomarker

Xinyao Hu et al.

Summary: The study showed that ASF1B is highly expressed in 22 cancers and is negatively correlated with the prognosis of multiple major cancer types. ASF1B expression was also correlated with TMB in 21 cancers and with MSI in 7 cancers. ASF1B may potentially serve as a prognostic marker and potential immunotherapeutic target for several malignancies due to its role in tumorigenesis and immune infiltration.

CANCER MEDICINE (2021)

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Article Oncology

Pregnancy Inhibits Mammary Carcinogenesis by Persistently Altering the Hypothalamic-Pituitary Axis

Ramadevi Subramani et al.

Summary: Early pregnancy reduces the lifetime risk of breast cancer by persistently altering the hypothalamic-pituitary hormonal axis, although the exact physiological mechanisms involved are not clear.

CANCERS (2021)

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Article Oncology

ASF1B Promotes Oncogenesis in Lung Adenocarcinoma and Other Cancer Types

Wencheng Zhang et al.

Summary: ASF1B is overexpressed in various types of cancer and regulated by multiple factors. Its expression is associated with survival in specific cancer types and correlates with immune cell infiltration, proliferation, and immune pathways. Knocking down ASF1B affects cell proliferation and apoptosis, while overexpression has no impact on malignant characteristics in lung adenocarcinoma cells.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

CircUBAP2 Promotes MMP9-Mediated Oncogenic Effect via Sponging miR-194-3p in Hepatocellular Carcinoma

Boqiang Liu et al.

Summary: This study identified a novel circRNA, circUBAP2, in hepatocellular carcinoma (HCC) through bioinformatics analysis. CircUBAP2 was significantly upregulated in HCC tissues and correlated with aggressive clinical characteristics and poor prognosis. Functionally, circUBAP2 promoted cell proliferation, colony formation, migration, and invasion in vitro, and enhanced tumor growth and pulmonary metastasis in vivo. Mechanistically, circUBAP2 acted as a competing endogenous RNA (ceRNA) for miR-194-3p, thereby regulating the expression of MMP9 and promoting HCC progression. CircUBAP2 could potentially serve as a prognostic biomarker and therapeutic target for HCC patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer

Dongbo Li et al.

CANCER SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Translation and functional roles of circular RNAs in human cancer

Ming Lei et al.

MOLECULAR CANCER (2020)

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Article Cell Biology

circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma

JunFeng Wang et al.

CELL DEATH & DISEASE (2020)

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Review Oncology

Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC)

Aaron C. Tan

THORACIC CANCER (2020)

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Article Biochemistry & Molecular Biology

SIK2 Promotes Cisplatin Resistance Induced by Aerobic Glycolysis in Breast Cancer Cells through PI3K/AKT/mTOR Signaling Pathway

Shoukai Zong et al.

BIOSCIENCE REPORTS (2020)

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Article Oncology

miR106a Promotes the Growth of Transplanted Breast Cancer and Decreases the Sensitivity of Transplanted Tumors to Cisplatin

Faping You et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Review Biochemistry & Molecular Biology

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Boris Y. Shorning et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer

Yuya Haga et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Oncology

Circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Weijun Hong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Cell Biology

ASF1B promotes cervical cancer progression through stabilization of CDK9

Xinjian Liu et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Elevated expression of FREM1 in breast cancer indicates favorable prognosis and high-level immune infiltration status

Han-ning Li et al.

CANCER MEDICINE (2020)

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Article Oncology

Inflammatory Blood Markers as Prognostic and Predictive Factors in Early Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Ileana Corbeau et al.

CANCERS (2020)

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Article Oncology

CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2

Yonghai Guan et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Biochemistry & Molecular Biology

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Junjie Xu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Medicine, Research & Experimental

SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer

Xi-Yu Liu et al.

THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Anti-silencing function 1B histone chaperone promotes cell proliferation and migration via activation of the AKT pathway in clear cell renal cell carcinoma

Zhou Jiangqiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

Xiaoxu Huang et al.

MOLECULAR CANCER (2019)

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Article Biotechnology & Applied Microbiology

circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer

Yuting Sang et al.

MOLECULAR THERAPY (2019)

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Review Oncology

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

Meran Keshawa Ediriweera et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Pharmacology & Pharmacy

PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges

Mohammad A. Khan et al.

DRUG DISCOVERY TODAY (2019)

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Review Oncology

CircRNAs in cancer metabolism: a review

Tao Yu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Oncology

A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer

Hiroyuki Katayama et al.

NPJ PRECISION ONCOLOGY (2019)

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Review Oncology

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

Ricardo L. B. Costa et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

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Article Plant Sciences

Rhizoma Amorphophalli inhibits TNBC cell proliferation, migration, invasion and metastasis through the PI3K/Akt/mTOR pathway

Chunyu Wu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

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Article Biotechnology & Applied Microbiology

MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition

Yuanyuan Kang et al.

ONCOTARGETS AND THERAPY (2018)

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Article Biochemistry & Molecular Biology

Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway

Shengting Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Cell Biology

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

Kyung-Min Lee et al.

CELL METABOLISM (2017)

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Article Biochemistry & Molecular Biology

Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer

Armelle Corpet et al.

EMBO JOURNAL (2011)

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Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis

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