CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression

Article Gastroenterology & Hepatology

Circular RNA PTK2 Accelerates Cell Proliferation and Inhibits Cell Apoptosis in Gastric Carcinoma via miR-139-3p

Deliang Yu et al.

Summary: The study revealed that circPTK2 is highly expressed in GC tissues and cells, promoting GC development by sponging miR-139-3p, which may serve as an effective gene target for managing GC.

DIGESTIVE DISEASES AND SCIENCES (2021)

添加到收藏夹

Article Cell Biology

miR-130b-3p regulates M1 macrophage polarization via targeting IRF1

Qiang Guo et al.

Summary: The study demonstrated that miR-130b-3p regulates the polarization of M1 macrophages by inhibiting IRF1, thus affecting inflammation. The miR-130b-3p/IRF1 pathway may be a potential target for regulating macrophage polarization.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

添加到收藏夹

Article

Tuberculous common bile duct stricture mimicking a cholangiocarcinoma: A case report

Hajar Adil et al.

Radiology Case Reports (2021)

添加到收藏夹

Article Food Science & Technology

Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells

Xiaochen Wu et al.

Summary: The novel compound DHC-1 exhibited potent and selective inhibition of PARP-1 activity, selectively targeting BRCA1 and BRCA2-deficient cancer cells. Mechanism studies showed that DHC-1 induced DNA double-strand damage and activated apoptotic pathways in the cells. Additionally, DHC-1 enhanced the cell proliferation inhibition effect of oxaliplatin and demonstrated promising results in inhibiting tumor growth in in vivo studies, making it a potential candidate for treating BRCA-deficient pancreatic cancers.

FOOD AND CHEMICAL TOXICOLOGY (2021)

添加到收藏夹

Article Oncology

A comparison of surgical resection and liver transplantation in the treatment of intrahepatic cholangiocarcinoma in the era of modern chemotherapy: An analysis of the National Cancer Database

Jonathan J. Hue et al.

Summary: The study indicated that there were no significant differences in postoperative outcomes and survival between hepatectomy and liver transplantation for patients with localized intrahepatic cholangiocarcinoma. Considering the resources and chronic immunosuppression required for transplantation, hepatectomy may be the preferable approach for treating localized ICC.

JOURNAL OF SURGICAL ONCOLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

LINC00839/miR-144-3p/WTAP (WT1 Associated protein) axis is involved in regulating hepatocellular carcinoma progression

Xingqin Zhou et al.

Summary: This study found that LINC00839 is upregulated in HCC and its oncogenic function in HCC cells is mediated by the miR-144-3p/WTAP axis. The results suggest that LINC00839 may serve as a therapeutic target and prognostic marker for HCC.

BIOENGINEERED (2021)

添加到收藏夹

Article Oncology

Circ_HIPK3 Knockdown Inhibits Cell Proliferation, Migration and Invasion of Cholangiocarcinoma Partly via Mediating the miR-148a-3p/ULK1 Pathway

Junning You et al.

Summary: This study found that circ_HIPK3 was overexpressed in CCA tissues and cells, and its knockdown inhibited cell proliferation, migration, and invasion while inducing apoptosis and cell cycle arrest. It was confirmed that miR-148a-3p was a target of circ_HIPK3, and ULK1 was a target of miR-148a-3p. Circ_HIPK3 regulated ULK1 expression by targeting miR-148a-3p.

CANCER MANAGEMENT AND RESEARCH (2021)

添加到收藏夹

Article Cell Biology

Circular RNA circSETD3 hampers cell growth, migration, and stem cell properties in bladder cancer through sponging miR-641 to upregulate PTEN

Ying Tian et al.

Summary: Bladder cancer is a common malignant urothelial cancer, and a novel circular RNA circSETD3 has been identified as a vital tumor suppressor in BLCA by regulating the miR-641/PTEN axis, thus inhibiting progression of the disease. Experimental results showed that circSETD3 was significantly downregulated in BLCA tissues and cell lines, and its deficiency was associated with larger tumors, advanced stages, lymph metastasis, and poor prognosis in BLCA patients.

CELL CYCLE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma

Le Tang et al.

Summary: This study revealed that circSETD3 promotes invasion and migration of NPC cells by competitively adsorbing miR-615-5p and miR-1538, thus regulating the expression of MAPRE1. This suggests circSETD3 could be a potential molecular marker and therapeutic target for NPC.

ONCOGENE (2021)

添加到收藏夹

Article Gastroenterology & Hepatology