Fabrication and Phase Behavior of Thermo- and/or pH-Responsive Polymer-Grafted SiO2 Nanoparticles

Three series of thermo- and/or pH-responsive polymer-grafted SiO2 nanoparticles, SiO2-graft-poly(oligo(ethylene glycol) methacrylate) (SiO2-g-POEGMA), SiO2-graft-poly(acrylic acid) (SiO2-g-PAA) and SiO2-graft-poly(oligo(ethylene glycol) methacrylate-state-acrylic acid (SiO2-g-P(OEGMA-stat-AA)), were prepared by grafting POEGMA and/or PAA onto the surface of silica nanoparticles through the surface-initiated atom transfer radical polymerization (SI-ATRP). The lower critical solution temperature (LCST) of SiO2-g-POEGMA (M-OEGMA = 300 g/mol) was found to be 64 degrees C. For SiO2-g-PAA nanoparticles, at the pH range from 8 to 12, the hydrodynamic diameter of the nanoparticles increases with increasing pH, and the zeta potential of SiO2-g-PAA nanoparticles is negatively charged and decreases with increasing pH. Owing to the thermo- and pH-responsive, the hydrodynamic diameters of SiO2-g-P(OEGMA-stat-AA) nanoparticles increase with the increasing pH, and the LCSTs of those nanoparticles increase with the increase of POEGMA content.

Automated summary

Three series of thermo- and/or pH-responsive polymer-grafted SiO2 nanoparticles were prepared by surface-initiated atom transfer radical polymerization. Different polymer grafts have different effects on the properties of the nanoparticles, such as LCST, hydrodynamic diameter, and zeta potential.