期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 12, 期 12, 页码 2097-2111出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2016.2319
关键词
Micelles; CK3; MPEG-PDLLA; Tumor Targeting; Breast Cancer; Paclitaxel
资金
- National Natural Science Foundation [NSFC31525009, NSFC31222023]
- National 863 Project [2015AA020316]
- Sichuan Innovative Research Team Program for Young Scientists [2016TD0004]
- Distinguished Young Scholars of Sichuan University [2011SCU04B18]
Chemotherapy for breast cancer is significantly restricted by the tumor's physio-pathological complexity. Here we have constructed a targeted nano-system based on PEGylated poly (D, L-lactide) (PEG-PDLLA) using a novel ligand, CLKA-DKAKC (CK3) peptide, for active targeting to Neuropilin-1-rich breast cancer cells. CK3 increased the cellular uptake of micelles 4.7-fold compared with the free drug and nearly 2.2-fold compared with the unmodified micelles (PM), respectively. Furthermore, in vivo imaging revealed that CK3-modified micelles (CK3-PM) had excellent specific tumor cells targeting and the drug accumulation was also enhanced. When paclitaxel (PTX) was loaded into micelles, CK3-PM-PTX induced the strongest inhibition and apoptosis against MDA-MB-231 cells in vitro and in vivo. These results demonstrated that CK3-modified PEG-PDLLA micelles developed in this study could be a potential targeted vehicle for enhancing the chemotherapy of breast cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据