期刊
APPLIED SCIENCES-BASEL
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/app12073464
关键词
alcohol; weekend consumption; oral cavity; damage; histological changes; tongue; cheek mucosa
类别
资金
- Secretaria de Investigacion y Posgrado, Instituto Politecnico Nacional [SIP-IPN:20220185]
The study found that weekend alcohol consumption for a period of 3 months causes alterations in oral-cavity tissues, which could contribute to the growth of oral tumors and the development of cancer.
The damage caused by chronic alcohol consumption is frequently reported, but the effects caused by weekend recreational consumption, which is much more frequent than even daily consumption, have not, to our knowledge, been reported. The metabolism of ethanol, once consumed, starts from the mouth, and the biotransformation process follows different routes. In this study, the effect of weekend alcohol consumption on the oral cavity was observed. Methods: Thirty male and female rats were divided into six groups (n = 5), with control groups (male/female) and groups administered with 5% and 40% ethanol solution ad libitum consumption 2 days a week for 3 months. After treatment, the animals were sacrificed, an incisional slice of the cheek and back of the tongue was obtained, and the tissues were processed according to the histological technique and routine staining (hematoxylin-eosin, H&E). Samples were observed using light microscopy. Results: Histological changes were observed in samples of tongue and cheek mucosa including different levels of keratinization of the surface layer. Epithelial dysplasia, acanthosis, and chronic inflammation were also observed. The vascularization level also increased because of the ethanol-induced damage. The results were very similar between female and male groups. Conclusion: Weekend alcohol consumption for a period of 3 months causes oral-cavity tissue alterations that could contribute to tumor growth and the development of cancer in the oral cavity.
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