期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 12, 期 7, 页码 1393-1403出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2016.2275
关键词
Folic Acid; gamma Cyclodextrin; C-60; Carboplatin; Drug Delivery
资金
- National Natural Science Foundation of China (NSFC) [81302728]
Folic acid (FA)-gamma cyclodextrin (gamma CD)-C-60 was synthesized in this study as a carrier for tumor-targeted drug delivery to enhance the anticancer effect of carboplatin (CBP). FA-gamma CD and C-60-CBP were prepared and C-60-CBP was then entrapped into FA-gamma CD through host-guest effect. FA-gamma CD-C-60 significantly increased the intracellular uptake and release of CBP, thereby providing higher cytotoxicity against the HeLa cells with high expression of folate receptor (FR). In vivo experiments revealed that FA-gamma CD-C-60-CBP had more significant anticancer effects than CBP alone, showing no obvious toxic effects on zebrafish at concentration as high as 500 mu g/mL. These results suggest that FA-gamma CD-C-60 may provide an effective strategy for administration of antineoplastics, with great promise in future targeted therapy for cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据