期刊
AMB EXPRESS
卷 12, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1186/s13568-022-01368-z
关键词
Monascus; Monacolin K; Solid state fermentation; Statistical parameter analysis
资金
- Youth Science Foundation in Shandong Province [ZR2020QC246]
- National Natural Science Foundation of China [32102073]
- Yunnan Science and Technology Planning Project [202102AE090021, 202102AE090021-03]
This study investigated the key factors for Monacolin K production through solid-state fermentation by Monascus ruber. The results showed that initial moisture and bran content were crucial for nutrient and oxygen transport. Under optimal conditions, the Monacolin K yield was higher compared to commercially available red yeast rice.
Monacolin K is one of the bioactive substances produced by Monascus ruber during fermentation. The multi-factors and their interactions on the effect of solid-state fermentation of Monascus for high yield of monacolin K were attractive to industrial production. A detailed study of 7 single-factor experiments and a series of experiments with Plackette-Burman and Box-Benhnken design, data fitting and modeling, and analyzing the visual 3D response surface plots for investigation of the key factors for Monacolin K production. The results showed that initial moisture (50 similar to 55%) and bran content (4.5 similar to 5.5%) as the key factors of transport for nutrients and oxygen during the solid-state fermentation (SSF) process of Monascus. Under the optimal conditions, a temperature shifting of the SSF with a higher Monacolin K yield of 14.53 +/- 0.16 mg.g(- 1) compared with the content of monacolin K in the commercially available functional red yeast rice of 8 mg g(-1).
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