4.8 Review

Cytotoxicity of Metal-Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Behavioral Sciences

A dose response effect of oral aluminum nanoparticle on novel object recognition memory, hippocampal caspase-3 and MAPKs signaling in mice

Nahid Mehrbeheshti et al.

Summary: This study demonstrated that oral gavage of nano-Al at doses of 5 and 10 mg/kg for 5 days impairs NOR memory in mice, along with an increase in phosphorylated p38, ERK, and cleaved caspase-3 in the hippocampus.

BEHAVIOURAL BRAIN RESEARCH (2022)

Article Chemistry, Multidisciplinary

Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stress

Jiazhen Wang et al.

Summary: Nano-titanium nitride (Nano-TiN) has been widely used in medical devices and jewelry due to its wear resistance, corrosion resistance, and biocompatibility. However, there are limited studies on the safety of Nano-TiN. This study found that Nano-TiN exposure caused dose- and time-dependent developmental toxicity in zebrafish embryos, affecting organ development and leading to oxidative stress.

DRUG AND CHEMICAL TOXICOLOGY (2022)

Article Environmental Sciences

Attributes of oxidative stress in the reproductive toxicity of nickel oxide nanoparticles in male rats

Meenu Singh et al.

Summary: The study aimed to investigate the role of oxidative stress in male reproductive toxicity induced by nickel oxide nanoparticles, finding that nickel oxide nanoparticles had adverse effects on the reproductive system of rats, leading to redox imbalance.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

Article Biochemistry & Molecular Biology

Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway

Jin Hou et al.

Summary: The study indicates that silver nanoparticles (AgNPs) can damage HC11 cells and induce autophagy, which is protective against AgNP-induced cell death. Additionally, AgNPs cause alterations in mitochondria and cellular oxidative stress, potentially leading to adverse effects on breast tissue. Further research is needed to understand the impact of AgNPs on lactation function and potential residues in milk.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

Review Toxicology

Neurotoxicity of metal-containing nanoparticles and implications in glial cells

Xiaoru Chang et al.

Summary: Metal-containing nanoparticles are widely used in the diagnosis, monitoring, and treatment of central nervous system diseases, but their neurotoxicity, especially on glial cells, is a cause for concern. Dysfunctions in microglial cells and astrocytes can damage the brain and contribute to the development of neurodegenerative diseases like Alzheimer's and Parkinson's. The mechanisms of neurotoxicity involve inflammation, oxidative stress, DNA damage, and cell death in glial cells, ultimately increasing the burden on the central nervous system.

JOURNAL OF APPLIED TOXICOLOGY (2021)

Article Materials Science, Biomaterials

Toxic mechanisms of Roth801, Canals, microparticles and nanoparticles of ZnO on MG-63 osteoblasts

Mei-Chi Chang et al.

Summary: The study revealed the toxic effects of ZnO particles on osteoblasts, resulting in DNA damage responses, cell cycle arrest, kinase activation, and signaling pathways. However, ZnO had little impact on the secretion of certain cytokines.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Review Chemistry, Multidisciplinary

Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective

Xujiang Yu et al.

Summary: Antimony (Sb)- and bismuth (Bi)-based nanoparticles, with the same chemical nature as semimetals, exhibit inherent multifunctionality for near-infrared laser-driven and/or X-ray-based cancer imaging and therapy, as well as other imparted functions, highlighting the relationship between chemical nature and multifunction in cancer theranostics.

ACS NANO (2021)

Article Marine & Freshwater Biology

Developmental titanium dioxide nanoparticle exposure induces oxidative stress and neurobehavioral changes in zebrafish

Jiangfei Chen et al.

Summary: Exposure to titanium dioxide nanoparticles during early development can lead to neurobehavioral changes in larval zebrafish, characterized by altered motor and social behaviors. These changes are associated with increased cell apoptosis and oxidative stress, potentially causing neuronal damage.

AQUATIC TOXICOLOGY (2021)

Article Environmental Sciences

Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway

Xiaoru Chang et al.

Summary: This study found that AgNPs can induce cytotoxicity in HT22 cells through autophagy and apoptosis pathways mediated by the PI3K/AKT/mTOR signaling pathway. These results provide experimental evidence and explanation for the potential neurotoxicity triggered by AgNPs in vitro.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Eugenol attenuates TiO2 nanoparticles-induced oxidative damage, biochemical toxicity and DNA damage in Wistar rats: an in vivo study

Mohammad Rafiq Wani et al.

Summary: Titanium dioxide nanoparticles are commonly used in various commercial products, but concerns have been raised about their potential toxicity, including oxidative damage and genotoxicity. This study investigated whether the dietary antioxidant eugenol could mitigate the toxicity induced by TiO2 NPs, showing promising results in reducing oxidative stress and cellular damage.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Article Environmental Sciences

Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine

Huijuan Kuang et al.

Summary: This study investigated the effects of ZnO nanoparticles on the female and male reproductive organs in mice, finding that ZnO NPs caused more severe reproductive toxicity in male mice. This included decreased testes weight, imbalance of hematological and serum biochemical parameters, and cell apoptosis. The study suggests that ZnO NPs could pose exposure-related risks to reproductive health, especially in occupational settings.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Toxicology

Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure

Jin Kwon Kim et al.

Summary: The results showed that the clearance of silver nanoparticles follows a two-phase model, while the clearance of gold nanoparticles could be described by a one-phase model. In the co-exposure of gold and silver nanoparticles, the clearance of silver nanoparticles was altered by the presence of gold, possibly due to some interaction affecting the dissolution and clearance of silver nanoparticles in vivo.

PARTICLE AND FIBRE TOXICOLOGY (2021)

Article Chemistry, Multidisciplinary

Assessment of the Influence of Crystalline Form on Cyto-Genotoxic and Inflammatory Effects Induced by TiO2 Nanoparticles on Human Bronchial and Alveolar Cells

Anna Maria Fresegna et al.

Summary: The study found that TiO2-A NPs induced cytotoxicity and slight inflammation in BEAS-2B cells, and slight oxidative effects in A549 cells, while TiO2-B NPs induced genotoxic/oxidative effects in both cell lines, revealing different toxicity mechanisms for the two tested NPs. The influence of crystalline form on cellular response was confirmed, demonstrating the suitability of the in vitro model to screen early TiO(2)NPs effects.

NANOMATERIALS (2021)

Article Environmental Sciences

Gold nanoparticles synergize with bacterial lipopolysaccharide to enhance class A scavenger receptor dependent particle uptake in neutrophils and augment neutrophil extracellular traps formation

Yongjun Yang et al.

Summary: The study demonstrates a synergistic effect of gold nanoparticles and bacterial lipopolysaccharide in promoting neutrophil extracellular traps release. This synergy is size-dependent, with 10 nm gold nanoparticles being more efficiently taken up by neutrophils compared to larger nanoparticles. Mechanisms involve upregulation of scavenger receptors, activation of ERK and p38 pathways, and the production of reactive oxygen species.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Pharmacology & Pharmacy

Bioevaluation methods for iron-oxide-based magnetic nanoparticles

Crt Dragar et al.

Summary: Despite the rapid development of iron-oxide-based magnetic nanoparticles (MNPs) as drug delivery systems, their clinical application still faces certain obstacles. Various in vitro studies have been conducted, but the selection of appropriate evaluation methods and cell lines should be based on the specific application of MNPs. This review provides a comprehensive overview of commonly used in vitro bioevaluation methods, aiming to facilitate reliable comparisons of different MNPs for efficient translation from research to clinical practice.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Environmental Sciences

Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae

Jie Gu et al.

Summary: The study revealed that early life stage exposure of zebrafish to nano-TiO2 adversely affects neural outcomes by inhibiting neurodevelopment and motor neuron axonal growth.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Nanoscience & Nanotechnology

Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death

Longbin Zhang et al.

Summary: This study reveals that activated Nrf2 and HO-1 play a negative regulatory role in endothelial cells under zinc oxide nanoparticles (ZnONPs) treatment, and the Nrf2-HO-1 axis is the crucial regulatory mechanism for antioxidative response.

NANOTOXICOLOGY (2021)

Article Cell Biology

Graphene Oxide-Silver Nanoparticle Nanocomposites Induce Oxidative Stress and Aberrant Methylation in Caprine Fetal Fibroblast Cells

Yu-Guo Yuan et al.

Summary: The study demonstrated that GO-AgNPs can induce cytotoxicity in CFFCs through increased generation of free radicals, cell apoptosis, and DNA hypomethylation, posing potential health risks.
Article Nanoscience & Nanotechnology

Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells

Kai Xiong et al.

Summary: This study presents a therapeutic copper polypyridine complex encapsulated in a natural nanocarrier, apoferritin, which shows higher cytotoxicity towards drug-resistant cancer cells compared to noncancerous cells. The compound triggers cell autophagy-dependent apoptosis, leading to cell death. Injection of this nanodrug conjugate into a mouse model with multidrug-resistant colon tumor results in a strong inhibition of tumor growth.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Environmental Sciences

Combined lead and zinc oxide-nanoparticles induced thyroid toxicity through 8-OHdG oxidative stress-mediated inflammation, apoptosis, and Nrf2 activation in rats

Eman El-Sayed Khayal et al.

Summary: The combined exposure of lead and zinc oxide-nanoparticles induced pronounced toxic thyroid injury in rats, leading to significant body weight reduction, increased thyroid weight, decreased thyroid function, elevated levels of lead and zinc accumulation, enhanced inflammatory responses, and promotion of cell apoptosis.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Biotechnology & Applied Microbiology

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Junhao Su et al.

Summary: The study revealed that exposure to TiO(2)NPs during pregnancy can cause delayed appearance of neurobehavioral impairments in offspring when they reach adulthood, even though these effects did not occur in the early stages of life after delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Immunology

NF-κB: At the Borders of Autoimmunity and Inflammation

Laura Barnabei et al.

Summary: NF-kappa B transcription factor plays a crucial role in regulating various aspects of innate and adaptive immune functions, serving as a key mediator of immune homeostasis. It is involved in central and peripheral tolerance, as well as the inactivation and destruction of autoreactive immune cells, contributing to immune tolerance. Furthermore, NF-kappa B plays a role in the pathogenesis of autoimmune diseases and has informed new therapeutic approaches for treating these conditions.

FRONTIERS IN IMMUNOLOGY (2021)

Article Agriculture, Dairy & Animal Science

Effects of Silver Nanoparticles on Proliferation and Apoptosis in Granulosa Cells of Chicken Preovulatory Follicles: An In Vitro Study

Dorota Katarzynska-Banasik et al.

Summary: The study demonstrated that AgNPs inhibited the proliferation of granulosa cells and promoted their apoptosis, indicating a potential disruption of the maturation and ovulation of preovulatory follicles by AgNPs.

ANIMALS (2021)

Article Materials Science, Multidisciplinary

Kinetic insight into perovskite La0.8Sr0.2VO3 nanofibers as an efficient electrocatalytic cathode for high-rate Li-O2 batteries

Myeong-Chang Sung et al.

Summary: The study showed that doping of La0.8Sr0.2VO3 nanofibers resulted in improved capacity and longer cycle life in Li-O-2 batteries, mainly due to crystal defects modulating oxygen reduction/evolution kinetics. In situ Raman analysis revealed a close relationship between structural defects and oxygen reduction/evolution behavior, leading to fewer parasitic reactions and offering insights into the potential rate capability of Li-O-2 batteries.

INFOMAT (2021)

Article Materials Science, Multidisciplinary

Dynamic structure change of Cu nanoparticles on carbon supports for CO2 electro-reduction toward multicarbon products

Qiang Li et al.

Summary: Cu nanoparticles with different sizes, morphology, and surface structures exhibit distinct activity and selectivity in CO2 reduction reaction. The study demonstrates that the dynamic structure change of Cu clusters on graphite-like carbon supports plays an important role in the production of multicarbon products. The study also reveals that the roughened surface morphologies resulting from the dynamic structure change of the catalysts play an essential role in the selectivity of CO2 electro-reduction.

INFOMAT (2021)

Article Materials Science, Multidisciplinary

A flexible metallic TiC nanofiber/vertical graphene 1D/2D heterostructured as active electrocatalyst for advanced Li-S batteries

Yongshang Zhang et al.

Summary: This study developed a flexible Li-S battery architecture based on electrocatalyzed cathodes, which successfully improved the conversion kinetics between sulfur species by enhancing both ion and electron transportation as well as affinity to polysulfides, leading to homogeneous deposition of Li2S in the catalyzed cathodes. The highly active electro-electrocatalysts-based cells exhibited remarkable rate capability and high specific capacity, even under ultra-high sulfur loading and low electrolyte/sulfur ratio conditions.

INFOMAT (2021)

Article Materials Science, Multidisciplinary

In-plane epitaxial growth of 2D CoSe-WSe2 metal-semiconductor lateral heterostructures with improved WSe2 transistors performance

Huifang Ma et al.

Summary: A high-quality growth method of metal-semiconductor lateral heterostructures was reported, and the structural characteristics were verified through various microscopy techniques. The field-effect transistors of CoSe-WSe2 lateral heterostructures demonstrated superior performance.

INFOMAT (2021)

Review Materials Science, Multidisciplinary

Nickel oxide thin films grown by chemical deposition techniques: Potential and challenges in next-generation rigid and flexible device applications

Mari Napari et al.

Summary: Nickel oxide (NiOx) is a key p-type oxide semiconductor with versatile and tunable properties, widely used in electronic devices. The properties of NiO(x) thin films strongly depend on the deposition method and conditions. Efficient implementation of NiO(x) in next-generation devices will require controllable growth and processing methods.

INFOMAT (2021)

Article Nanoscience & Nanotechnology

Length-dependent toxicity of TiO2 nanofibers: mitigation via shortening

Massimiliano G. Bianchi et al.

NANOTOXICOLOGY (2020)

Article Environmental Sciences

Neurotoxicity and biomarkers of zinc oxide nanoparticles in main functional brain regions and dopaminergic neurons

Huanliang Liu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Environmental Sciences

DNA damage detection by Comet Assay on Daphnia magna: Application in freshwater biomonitoring

Valerio Pellegri et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Developmental Biology

Toxic effects of maternal exposure to silver nanoparticles on mice fetal development during pregnancy

Maryam Mozafari et al.

BIRTH DEFECTS RESEARCH (2020)

Article Neurosciences

In deep evaluation of the neurotoxicity of orally administered TiO2 nanoparticles

Intissar Grissa et al.

BRAIN RESEARCH BULLETIN (2020)

Article Cardiac & Cardiovascular Systems

Oxidative stress – A unifying paradigm in hypertension

Rhian M. Touyz et al.

CANADIAN JOURNAL OF CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes

Jose Antonio Perez-Arizti et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Article Environmental Sciences

Genotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test

Donglei Sun et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

Review Biotechnology & Applied Microbiology

Application of the comet assay in human biomonitoring: An hCOMET perspective

Amaya Azqueta et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2020)

Editorial Material Chemistry, Multidisciplinary

The Future in Nanosafety

Jo Anne Shatkin

NANO LETTERS (2020)

Article Toxicology

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

Sivakumar Murugadoss et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

Review Chemistry, Multidisciplinary

Metal-Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Pooyan Makvandi et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Environmental Sciences

Nuclear Factor kappa B activation by Ag, Au nanoparticles, CdTe quantum dots or their binary mixtures in HepG2 cells

Lucyna Kapka-Skrzypczak et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Zinc oxide nanoparticles induce human tenon fibroblast apoptosis through reactive oxygen species and caspase signaling pathway

Ling Wang et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Review Biochemistry & Molecular Biology

Glycolysis - a key player in the inflammatory response

Gonzalo Soto-Heredero et al.

FEBS JOURNAL (2020)

Article Biochemistry & Molecular Biology

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

Roberta Giordo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Lactate dehydrogenase: a marker of diminished antitumor immunity

Sandra Van Wilpe et al.

ONCOIMMUNOLOGY (2020)

Article Chemistry, Multidisciplinary

Gold Nanoparticles Induce Oxidative Stress and Apoptosis in Human Kidney Cells

Maria Enea et al.

NANOMATERIALS (2020)

Review Chemistry, Multidisciplinary

Toxicity of metal and metal oxide nanoparticles: a review

Ayse Busra Sengul et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2020)

Article Biology

Neuro-biochemical changes induced by zinc oxide nanoparticles

Mohamed A. Dkhil et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Nanoscience & Nanotechnology

Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats

Juliana Lis Mendes de Brito et al.

NANOTOXICOLOGY (2020)

Article Reproductive Biology

Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles

Ramses Santacruz-Marquez et al.

REPRODUCTIVE TOXICOLOGY (2020)

Review Environmental Sciences

The mechanisms and environmental implications of engineered nanoparticles dispersion

Di Zhang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Nanoscience & Nanotechnology

Sex differences in the acute and subchronic lung inflammatory responses of mice to nickel nanoparticles

Dorothy J. You et al.

NANOTOXICOLOGY (2020)

Review Immunology

Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets

Justina Kulikauskaite et al.

TRENDS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Early Postnatal Exposure to a Low Dose of Nanoparticulate Silver Induces Alterations in Glutamate Transporters in Brain of Immature Rats

Beata Dabrowska-Bouta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemical Research Methods

An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity

Sona Vodenkova et al.

NATURE PROTOCOLS (2020)

Article Nanoscience & Nanotechnology

The Effects of Gold Nanoparticles on Leydig Cells and Male Reproductive Function in Mice

Ying Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Materials Science, Multidisciplinary

Flexible Na batteries

Chenglong Zhao et al.

INFOMAT (2020)

Review Materials Science, Multidisciplinary

Mechanistic understanding of the role separators playing in advanced lithium-sulfur batteries

Zhaohuan Wei et al.

INFOMAT (2020)

Article Toxicology

Titanium dioxide nanoparticles induce in vitro autophagy

X. Dai et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2019)

Review Materials Science, Multidisciplinary

Nanomaterials as photothermal therapeutic agents

Junqi Chen et al.

PROGRESS IN MATERIALS SCIENCE (2019)

Review Biotechnology & Applied Microbiology

Recent developments in colorimetric immunoassays using nanozymes and plasmonic nanoparticles

Azureen Mohamad et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats

Xuerong Zhou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Endocrinology & Metabolism

Evaluation of neuroglobin and cytoglobin expression in adult rats exposed to silver nanoparticles during prepubescence

Rodrigo Rodrigues da Conceicao et al.

METABOLIC BRAIN DISEASE (2019)

Article Biotechnology & Applied Microbiology

SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice

Fenju Qin et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Marina P. Sutunkova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Materials Science, Biomaterials

Controlled nanoparticle synthesis of Ag/Fe co-doped hydroxyapatite system for cancer cell treatment

Sarath Chandra Veerla et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Agriculture, Multidisciplinary

Effect of Long-Term Intake of Dietary Titanium Dioxide Nanoparticles on Intestine Inflammation in Mice

Wei Mu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

In Vitro Toxicity of TiO2:SiO2 Nanocomposites with Different Photocatalytic Properties

Rossella Bengalli et al.

NANOMATERIALS (2019)

Article Environmental Sciences

Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio)

Jing Hou et al.

CHEMOSPHERE (2019)

Article Environmental Sciences

Bioaccumulation and toxic effects of nanoparticulate and ionic silver in Saccostrea glomerata (rock oyster)

Ana Carrazco-Quevedo et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

Article Nanoscience & Nanotechnology

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

Barbara Pem et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2019)

Review Pharmacology & Pharmacy

Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy

Prashant Sharma et al.

PHARMACEUTICS (2019)

Article Environmental Sciences

Shape-dependent toxicity of alumina nanoparticles in rat astrocytes

Li Dong et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Environmental Sciences

Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish

Qin Wu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Biochemistry & Molecular Biology

A real-time, bioluminescent annexin V assay for the assessment of apoptosis

Kevin Kupcho et al.

APOPTOSIS (2019)

Article Environmental Sciences

Toxic and Genotoxic Effects of Silver Nanoparticles in Drosophila

Mohamed Alaraby et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2019)

Article Engineering, Biomedical

Suppression of ovarian follicle development by nano TiO2 is associated with TGF-β-mediated signaling pathways

Yingjun Zhou et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

Article Nanoscience & Nanotechnology

ZnO Nanoparticles Induced Male Reproductive Toxicity Based on the Effects on the Endoplasmic Reticulum Stress Signaling Pathway

Yizhou Tang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Biotechnology & Applied Microbiology

Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells

Marie Dorier et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2019)

Article Environmental Sciences

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

Khaled Greish et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Article Respiratory System

Airway inflammation after inhalation of nano-sized zinc oxide particles in human volunteers

Christian Monse et al.

BMC PULMONARY MEDICINE (2019)

Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

Article Nanoscience & Nanotechnology

Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice

Fashui Hong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Article Engineering, Environmental

Ocean acidification increases the toxic effects of TiO2 nanoparticles on the marine microalga Chlorella vulgaris

Bin Xia et al.

JOURNAL OF HAZARDOUS MATERIALS (2018)

Article Materials Science, Biomaterials

Green synthesized silver nanoparticles: Catalytic dye degradation, in vitro anticancer activity and in vivo toxicity in rats

Jayachandra Reddy Nakkala et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Article Nanoscience & Nanotechnology

Gold nanoparticles: Distribution, bioaccumulation and toxicity. In vitro and in vivo studies

Carlos Lopez-Chaves et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Article Chemistry, Multidisciplinary

Coating Dependent In Vitro Biocompatibility of New Fe-Si Nanoparticles

Mihaela Balas et al.

NANOMATERIALS (2018)

Article Environmental Sciences

Autophagic effects and mechanisms of silver nanoparticles in renal cells under low dose exposure

Yue Chen et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

Article Multidisciplinary Sciences

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhenyu Zhong et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Transcriptional Regulation by Nrf2

Claudia Tonelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Environmental Sciences

Silver nanoparticles alter learning and memory formation in an aquatic organism, Lymnaea stagnalis

Austin Young et al.

ENVIRONMENTAL POLLUTION (2017)

Article Environmental Sciences

Immunotoxic effects of thymus in mice following exposure to nanoparticulate TiO2

Fashui Hong et al.

ENVIRONMENTAL TOXICOLOGY (2017)

Article Nanoscience & Nanotechnology

Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by nano-sized gadolinium oxide

Saud Alarifi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Biochemistry & Molecular Biology

Effect of Orally Administered Zinc Oxide Nanoparticles on Albino Rat Thymus and Spleen

Marwa A. Abass et al.

IUBMB LIFE (2017)

Article Toxicology

Iron oxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in lymphocytes

Usha Singh Gaharwar et al.

JOURNAL OF APPLIED TOXICOLOGY (2017)

Article Engineering, Biomedical

Toxic effects of TiO2 nanoparticles in primary cultured rat sertoli cells are mediated via a dysregulated Ca2+/PKC/p38 MAPK/NF-κB cascade

Lingqun Ye et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

Article Neurosciences

Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice

Vasanth Dhakshinamoorthy et al.

NEUROTOXICITY RESEARCH (2017)

Article Materials Science, Biomaterials

Uniform TiO2 nanoparticles induce apoptosis in epithelial cell lines in a size-dependent manner

Qingqing Sun et al.

BIOMATERIALS SCIENCE (2017)

Article Developmental Biology

Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo

Robert A. Goodlad

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2017)

Article Multidisciplinary Sciences

Acute toxicity and genotoxicity of silver nanoparticle in rats

Hairuo Wen et al.

PLOS ONE (2017)

Article Nanoscience & Nanotechnology

Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound

Dong Gil You et al.

NANO CONVERGENCE (2017)

Article Marine & Freshwater Biology

Integrated assessment of toxic effects of maghemite (γ-Fe2O3) nanoparticles in zebrafish

Rolando A. R. Villacis et al.

AQUATIC TOXICOLOGY (2017)

Article Allergy

Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity

E. Taher Taher et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2017)

Review Immunology

Innate immunity in vertebrates: an overview

Mario Riera Romo et al.

IMMUNOLOGY (2016)

Article Pharmacology & Pharmacy

In Vitro Toxicological Assessment of Magnesium Oxide Nanoparticle Exposure in Several Mammalian Cell Types

Abudayyak Mahmoud et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2016)

Article Chemistry, Multidisciplinary

The nano-TiO2 exposure can induce hepatic inflammation involving in a JAK-STAT signalling pathway

Jie Hong et al.

JOURNAL OF NANOPARTICLE RESEARCH (2016)

Review Chemistry, Medicinal

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Meng-Chen Lu et al.

MEDICINAL RESEARCH REVIEWS (2016)

Article Multidisciplinary Sciences

Nickel Release, ROS Generation and Toxicity of Ni and NiO Micro- and Nanoparticles

Siiri Latvala et al.

PLOS ONE (2016)

Article Biochemistry & Molecular Biology

Accumulation and Toxicity of Superparamagnetic Iron Oxide Nanoparticles in Cells and Experimental Animals

Greta Jarockyte et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Medicine, Research & Experimental

Using the comet and micronucleus assays for genotoxicity studies: A review

Rodrigo Pinheiro Araldi et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

Article Biochemical Research Methods

Development of a microfluidic-based assay on a novel nitrocellulose platform

Mary Arrastia et al.

ELECTROPHORESIS (2015)

Article Immunology

Increased Sensitivity of HIV-1 p24 ELISA Using a Photochemical Signal Amplification System

Simon Bystryak et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2015)

Article Nanoscience & Nanotechnology

Toxicological effect of TiO2 nanoparticle-induced myocarditis in mice

Fashui Hong et al.

NANOSCALE RESEARCH LETTERS (2015)

Article Nanoscience & Nanotechnology

Molecular mechanism of silver nanoparticles in human intestinal cells

Linda Boehmert et al.

NANOTOXICOLOGY (2015)

Article Multidisciplinary Sciences

Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line

Akhilesh Dubey et al.

PLOS ONE (2015)

Article Gastroenterology & Hepatology

Biological effects of low-dose-rate irradiation of pancreatic carcinoma cells in vitro using 125I seeds

Zhong-Min Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction

Lei Tian et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

Zinc ferrite nanoparticle-induced cytotoxicity and oxidative stress in different human cells

Hisham A. Alhadlaq et al.

CELL AND BIOSCIENCE (2015)

Article Nanoscience & Nanotechnology

Toxicological effect of TiO2 nanoparticle-induced myocarditis in mice

Fashui Hong et al.

NANOSCALE RESEARCH LETTERS (2015)

Article Nanoscience & Nanotechnology

Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles

Zuzana Magdolenova et al.

NANOTOXICOLOGY (2015)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Biophysics

Statistical analysis of gold nanoparticle-induced oxidative stress and apoptosis in myoblast (C2C12) cells

Rizwan Wahab et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

Article Engineering, Biomedical

Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

Yuguan Ze et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Article Plant Sciences

Impact of TiO2 nanoparticles on Vicia narbonensis L.: potential toxicity effects

M. Ruffini Castiglione et al.

PROTOPLASMA (2014)

Article Medicine, Research & Experimental

Ultrastructural characterization of mesenchymal stromal cells labeled with ultrasmall superparamagnetic iron-oxide nanoparticles for clinical tracking studies

Louise Hansen et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2014)

Review Pharmacology & Pharmacy

Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells

Naveena Yanamala et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Agriculture, Multidisciplinary

Renal Injury and Nrf2 Modulation in Mouse Kidney Following Chronic Exposure to TiO2 Nanoparticles

Suxin Gui et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Article Allergy

Natural killer cell deficiency

Jordan S. Orange

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Development, maintenance and disruption of the blood-brain barrier

Birgit Obermeier et al.

NATURE MEDICINE (2013)

Article Nanoscience & Nanotechnology

In vitro toxicity of different-sized ZnO nanoparticles in Caco-2 cells

Tianshu Kang et al.

NANOSCALE RESEARCH LETTERS (2013)

Review Biochemistry & Molecular Biology

Regulatory T cells, mTOR kinase, and metabolic activity

Claudio Procaccini et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Engineering, Biomedical

The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles

Xuezi Sang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2012)

Review Nanoscience & Nanotechnology

Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward

David Y. Lai

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2012)

Article Biotechnology & Applied Microbiology

Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

Liming Xu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

Aqueous Synthesis and Concentration-Dependent Dermal Toxicity of TiO2 Nanoparticles in Wistar Rats

Jyotisree Unnithan et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2011)

Review Cell Biology

Signal transduction by reactive oxygen species

Toren Finkel

JOURNAL OF CELL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Thymidine Analogues for Tracking DNA Synthesis

Brenton L. Cavanagh et al.

MOLECULES (2011)

Article Nanoscience & Nanotechnology

Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells

Meike Winter et al.

NANOTOXICOLOGY (2011)

Article Marine & Freshwater Biology

Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish

Ji Eun Choi et al.

AQUATIC TOXICOLOGY (2010)

Review Biochemistry & Molecular Biology

mTOR regulation of autophagy

Chang Hwa Jung et al.

FEBS LETTERS (2010)

Review Biochemistry & Molecular Biology

Reactive oxygen species, cellular redox systems, and apoptosis

Magdalena L. Circu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Engineering, Biomedical

The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation

Lily Peng et al.

BIOMATERIALS (2009)

Article Toxicology

Genotoxic effects of nanosized and fine TiO2

G. C. M. Falck et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2009)

Review Biochemistry & Molecular Biology

Autophagy in the pathogenesis of disease

Beth Levine et al.

Editorial Material Multidisciplinary Sciences

Inflammation

Ursula Weiss

NATURE (2008)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Article Biochemistry & Molecular Biology

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

K Ito et al.

NATURE MEDICINE (2006)

Review Biochemistry & Molecular Biology

Mammalian initiator apoptotic caspases

PK Ho et al.

FEBS JOURNAL (2005)

Article Toxicology

Comparison of alamar blue and MTT assays for high through-put screening

R Hamid et al.

TOXICOLOGY IN VITRO (2004)

Review Anatomy & Morphology

Detection of reactive oxygen and reactive nitrogen species in skeletal muscle

CL Murrant et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2001)

Article Medicine, General & Internal

What is apoptosis, and why is it important?

AG Renehan et al.

BMJ-BRITISH MEDICAL JOURNAL (2001)

Article Medicine, General & Internal

An overview of the immune system

J Parkin et al.

LANCET (2001)