期刊
ADVANCED SCIENCE
卷 9, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/advs.202202283
关键词
carbon dots; near-infrared absorption; near-infrared bioimaging; near-infrared emission; perylene derivatives; two-photon fluorescence
资金
- National Natural Science Foundation of China [61922091]
- Science and Technology Development Fund of Macau SAR [0040/2019/A1, 0073/2019/AMJ, 0011/2019/AKP, 0128/2020/A3, 0120/2020/A3, 0026/2021/A, 0131/2020/A3]
- Shenzhen-Hong Kong-Macao Science and Technology Innovation Project (Category C) [SGDX20210823103803021]
- University of Macau [SRG2019-00163-IAPME, CPG2020-00026-IAPME, MYRG2019-00103-IAPME, MYRG2020-00164-IAPME]
This study successfully fabricated carbon dots (CDs) with dominant near-infrared (NIR) absorption/emission peaks in aqueous solution and enhanced their photoluminescence quantum yields (PLQY) through surface engineering. Compared to commercial NIR dyes, these modified CDs exhibit improved photostability and lower cost, and they also demonstrate advantages in in vivo bioimaging.
Carbon dots (CDs) have attracted significant interest as one of the most emerging photoluminescence (PL) nanomaterials. However, the realization of CDs with dominant near-infrared (NIR) absorption/emission peaks in aqueous solution remains a great challenge. Herein, CDs with both main NIR absorption bands at 720 nm and NIR emission bands at 745 nm in an aqueous solution are fabricated for the first time by fusing large conjugated perylene derivatives under solvothermal treatment. With post-surface engineering, the polyethyleneimine modified CDs (PEI-CDs) exhibit enhanced PL quantum yields (PLQY) up to 8.3% and 18.8% in bovine serum albumin aqueous and DMF solutions, which is the highest PLQY of CDs in NIR region under NIR excitation. Density functional theory calculations support the strategy of fusing large conjugated perylene derivatives to achieve NIR emissions from CDs. Compared to the commercial NIR dye Indocyanine green, PEI-CDs exhibit excellent photostability and much lower cost. Furthermore, the obtained PEI-CDs illustrate the advantages of remarkable two-photon NIR angiography and in vivo NIR fluorescence bioimaging. This work demonstrates a promising strategy of fusing large conjugated molecules for preparing CDs with strong NIR absorption/emission to promote their bioimaging applications.
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