期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 105, 期 6, 页码 1692-1716出版社
WILEY
DOI: 10.1002/jbm.b.33648
关键词
PLGA copolymers; biodegradation; physicochemical properties; drug delivery; analytical theory
资金
- MilliporeSigma
- College of Engineering and Applied Science (CEAS), UWM
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact the degradation rates of PLGA polymers and concurrent drug release kinetics. This work is intended to provide a comprehensive and collective review of the physicochemical and physiological factors that dictate the degradation behavior of PLGA polymers and drug release from contemporary PLGA-based drug-polymer products. In conjunction with the existing experimental results, analytical and numerical theories developed to predict drug release from PLGA-based polymers are summarized and correlated with the experimental observations. (C) 2016 Wiley Periodicals, Inc.
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